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Absence of an aging-related increase in fiber type grouping in athletes and non-athletes

Messa, Guy A.M. and Piasecki, Mathew and Rittweger, Jörn and McPhee, Jamie and Koltai, Erika and Radak, Zsolt and Simunic, Bostjan and Heinonen, Ari and Suominen, Harri and Korhonen, Marko and Degens, Hans (2020) Absence of an aging-related increase in fiber type grouping in athletes and non-athletes. Scandinavian Journal of Medicine & Science in Sport, 30 (11), pp. 2057-2069. Wiley. doi: 10.1111/sms.13778. ISSN 0905-7188.

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Official URL: https://onlinelibrary.wiley.com/doi/full/10.1111/sms.13778

Abstract

The aging-related loss of muscle mass is thought to be partly attributable to motor neuron loss and motor unit remodeling that result in fiber type grouping. We examined fiber type grouping in 19- to 85-year-old athletes and non-athletes and evaluated to which extent any observed grouping is explained by the fiber type composition of the muscle. Since regular physical activity may stimulate reinnervation, we hypothesized that fiber groups are larger in master athletes than in age-matched nonathletes. Fiber type grouping was assessed in m. vastus lateralis biopsies from 22 young (19-27 years) and 35 healthy older (66-82 years) non-athletes, and 14 young (20-29 years), 51 middle-aged (38-65 years), and 31 older (66-85 years) athletes. An “enclosed fiber” was any muscle fiber of a particular type surrounded by fibers of the same type only. A fiber type group was defined as a group of fibers with at least one enclosed fiber. Only type II fiber cross-sectional area (FCSA) showed an age-related decline that was greater in athletes (P < .001) than in non-athletes (P = .012). There was no significant age-related effect on fiber group size or fiber group number in athletes or non-athletes, and the observed grouping was similar to that expected from the fiber type composition. At face value, these observations do 1) neither show evidence for an age-related loss and remodeling of motor units nor 2) improved reinnervation with regular physical activity, but 3) histological examination may not reveal the full extent of aging-related motor unit remodeling

Item URL in elib:https://elib.dlr.de/137104/
Document Type:Article
Title:Absence of an aging-related increase in fiber type grouping in athletes and non-athletes
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Messa, Guy A.M.Department of Life Sciences, Research Centre for Musculoskeletal Science and Sports Medicine, Manchester Metropolitan University, Manchester, UKUNSPECIFIED
Piasecki, MathewMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UKUNSPECIFIED
Rittweger, JörnJoern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
McPhee, JamieManchester MetropolitanUNSPECIFIED
Koltai, ErikaResearch Institute of Sport Science, University of Physical Education, Budapest, HungaryUNSPECIFIED
Radak, ZsoltResearch Institute of Sport Science, University of Physical Education, Budapest, HungaryUNSPECIFIED
Simunic, BostjanUniversity of Primorska, SloveniaUNSPECIFIED
Heinonen, AriUniversity of JyväskyäUNSPECIFIED
Suominen, HarriUniversity of JyväskyäUNSPECIFIED
Korhonen, MarkoUniversity of JyväskyäUNSPECIFIED
Degens, HansManchester Metropolitan UniversityUNSPECIFIED
Date:July 2020
Journal or Publication Title:Scandinavian Journal of Medicine & Science in Sport
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:30
DOI :10.1111/sms.13778
Page Range:pp. 2057-2069
Publisher:Wiley
ISSN:0905-7188
Status:Published
Keywords:aging, denervation, fiber type, grouping, reinnervation, vastus lateralis
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Arndt, Carina
Deposited On:05 Nov 2020 17:11
Last Modified:05 Nov 2020 17:11

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