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Caffeine effectively counteracts performance impairments during the first two days of chronic sleep restriction in genetically caffeine-sensitive individuals

Elmenhorst, E.-M. and Elmenhorst, D. and Lange, D. and Baur, D. and Fronczek-Poncelet, J. and Hennecke, E. and Bauer, A. and Landolt, H.-P. and Aeschbach, D. (2020) Caffeine effectively counteracts performance impairments during the first two days of chronic sleep restriction in genetically caffeine-sensitive individuals. In: JOURNAL OF SLEEP RESEARCH, 29 (S1), pp. 13-14. 25th Congress of the European Sleep Research Society, 22.-24. September 2020, virtuell.

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Abstract

Objectives/Introduction: Caffeine is commonly trusted to counteract the performance impairing effects of sleep loss. However, the knowledge on the day-to-day efficacy of caffeine in preserving optimal performance under conditions of chronic sleep restriction is scarce. We investigated the efficacy of caffeine in individuals who carry the C/C-allele of the adenosine A2A receptor (ADORA c.1976), a genotype known to have a high caffeine-sensitivity. Methods: We examined 71 healthy volunteers aged 20 to 40 years in the lab. After one adaptation and two baseline days with prior 8h time in bed (TIB) each, (1) the control group (CO, n=15, 5 female) had 8h TIB for the following six nights, (2) the restriction group (RG, n=21, 9 female) had five days (E1 to E5) with prior 5h TIB followed by an recovery day (Rec) after 8h TIB, (3) the caffeine group (Caff, n=19, 8 female) had the same schedule as the RG, but received standardized 600 ml coffee (∼300 mg caffeine) per day during E1 to E4 and 400 ml coffee (∼200 mg caffeine) on E5, (4) the decaff group (Decaff, n=16, 7 female) underwent the same schedule as the Caff, but consumed decaffeinated coffee. The Caff and Decaff participants carried the caffeine-sensitive genotype. Mixed ANOVAs with Bonferroni adjusted α<0.016 compared the impairment in participants’ mean daytime (at 2h, 5h, 11h, and 15h awake) speed (1/reaction time) as difference to baseline on a 10-min Psychomotor Vigilance Task. Results: Speed in the RG was impaired compared to the CO at E1 to E5 (p< 0.009), but not at Rec (p=0.103). In the Caff speed was faster than in the Decaff at E1 (p=0.014) and faster than in the RG at E1 and E2 (p< 0.002), but slower than in the CO at E3 to Rec (p< 0.014). At 11h awake, speed in the Decaff was faster than in the RG at E1 and E2, but slower than in the CO at E3 to E5 (p< 0.006). Conclusions: Under chronic sleep restriction, ∼300 mg caffeine per day kept performance at rested levels for two days. Decaffeinated coffee also seemed to be beneficial. The use of caffeine delayed recovery.

Item URL in elib:https://elib.dlr.de/136501/
Document Type:Conference or Workshop Item (Speech)
Title:Caffeine effectively counteracts performance impairments during the first two days of chronic sleep restriction in genetically caffeine-sensitive individuals
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Elmenhorst, E.-M.Eva-Maria.Elmenhorst (at) dlr.dehttps://orcid.org/0000-0003-0336-6705
Elmenhorst, D.FZ JülichUNSPECIFIED
Lange, D.denise.lange (at) dlr.deUNSPECIFIED
Baur, D.UNSPECIFIEDUNSPECIFIED
Fronczek-Poncelet, J.UNSPECIFIEDUNSPECIFIED
Hennecke, E.UNSPECIFIEDUNSPECIFIED
Bauer, A.UNSPECIFIEDUNSPECIFIED
Landolt, H.-P.UNSPECIFIEDUNSPECIFIED
Aeschbach, D.daniel.aeschbach (at) dlr.deUNSPECIFIED
Date:2020
Journal or Publication Title:JOURNAL OF SLEEP RESEARCH
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:Yes
Volume:29
Page Range:pp. 13-14
Status:Published
Keywords:Cognitive performance, sleep restriction, caffeine, psychomotor vigilance, adenosine
Event Title:25th Congress of the European Sleep Research Society
Event Location:virtuell
Event Type:international Conference
Event Dates:22.-24. September 2020
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Aeronautics
HGF - Program Themes:air traffic management and operations
DLR - Research area:Aeronautics
DLR - Program:L AO - Air Traffic Management and Operation
DLR - Research theme (Project):L - Human factors and safety in Aeronautics (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Sleep and Human Factors Research
Deposited By: Sender, Alina
Deposited On:29 Oct 2020 12:46
Last Modified:29 Oct 2020 12:46

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