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Whey protein supplementation with vibration exercise ameliorates lumbar paraspinal muscle atrophy in prolonged bed rest

Owen, Patrick J. and Armbrecht, Gabriele and Bansmann, Martin and Zange, Jochen and Pohle-Fröhlich, Regina and Felsenberg, Dieter and Belavy, Daniel L. (2020) Whey protein supplementation with vibration exercise ameliorates lumbar paraspinal muscle atrophy in prolonged bed rest. Journal of Applied Physiology, 128 (6), pp. 1568-1578. American Physiological Society. doi: 10.1152/japplphysiol.00125.2020. ISSN 8750-7587.

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Official URL: https://doi.org/10.1152/japplphysiol.00125.2020

Abstract

Optimizing countermeasures for musculoskeletal deterioration during spaceflight is a priority for space agencies. We examined the impact of adding whey protein supplementation to resistive vibration exercise (RVE) on lumbar deconditioning during prolonged bed rest. Participants (n = 12) were enrolled in a crossover design study of 21 days of bed rest with RVE (2 days/wk, 2-4 min/session time under tension), whey protein supplementation plus RVE (NeX), and no-intervention control (CNT). After bed rest, NeX [-2.2 (7.0)%, P = 0.370], but not RVE [-5.6 (6.4)%, P = 0.0027], reduced paraspinal muscle atrophy compared with CNT [-6.1 (5.5)%, P = 0.00035]. After 3 days of bed rest, whole intervertebral disk (IVD) T2 increased in all groups [CNT: +5.3 (2.5)%, P < 0.0001; NeX: +6.3 (1.8)%, P < 0.0001; RVE: +6.3 (1.9)%, P < 0.0001] and remained at this level on day 21 of bed rest [CNT: 5.5 (2.6)%, P < 0.0001; NeX: 6.0 (1.8)%, P < 0.0001; RVE: 6.2 (2.8)%, P < 0.0001]. Increases in IVD T2 were greatest in the nucleus [10.9 (1.1)%, P < 0.0001], with reductions of T2 observed in the anterior annulus [-4.4 (1.0) %, P = 0.00001] and increases in the posterior annulus [2.1 (0.8)%, P = 0.011]. At 6 and 28 days post-bed rest, IVD T2 was similar compared with baseline for all groups. A similar pattern was seen for IVD height, although a -3.8 (4.6)% (P = 0.0052) reduction of IVD height was seen 28 days after bed rest in the CNT group. The countermeasures did not impact on the presence or intensity of back pain during or after bed rest. Participants reporting back pain on day 3 of bed rest had greater (P = 0.013) increases in intervertebral disk volume than participants who did not. Although neither countermeasure impacted IVD changes or back pain in prolonged bed rest, NeX, but not RVE alone, ameliorated paraspinal muscle atrophy.NEW & NOTEWORTHY We examined the impact of adding protein supplementation to exercise (resistive vibration exercise) as a countermeasure against changes in the spine during spaceflight simulation. We found that adding the protein supplementation reduced spine muscle atrophy more than exercise alone. Neither countermeasure approach prevented changes in the disks in the spine or impacted back pain reports.

Item URL in elib:https://elib.dlr.de/136063/
Document Type:Article
Title:Whey protein supplementation with vibration exercise ameliorates lumbar paraspinal muscle atrophy in prolonged bed rest
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Owen, Patrick J.Deakin University, Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Geelong, Victoria, Australiahttps://orcid.org/0000-0003-3924-9375
Armbrecht, GabrieleCharite - University Medicine BerlinUNSPECIFIED
Bansmann, MartinKrankenhaus PorzUNSPECIFIED
Zange, JochenJochen.Zange (at) dlr.dehttps://orcid.org/0000-0003-1822-0952
Pohle-Fröhlich, Reginahochschule niederrhein, institute for pattern recognition, krefeldUNSPECIFIED
Felsenberg, DieterCharite - Universitätsmedizin BerlinUNSPECIFIED
Belavy, Daniel L.Deakin University, AustraliaUNSPECIFIED
Date:8 June 2020
Journal or Publication Title:Journal of Applied Physiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:128
DOI :10.1152/japplphysiol.00125.2020
Page Range:pp. 1568-1578
Publisher:American Physiological Society
ISSN:8750-7587
Status:Published
Keywords:atrophy; diet therapy; intervertebral disc; muscle; rehabilitation; space flight
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Arndt, Carina
Deposited On:16 Sep 2020 10:00
Last Modified:16 Sep 2020 10:00

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