Hupfeld, Kathleen E. and McGregor, Heather R. and Lee, Jessica K. and Beltran, Nichole E. and Korman, Igor S. and De Dios, Yiri E. and Reuter-Lorenz, Patti A. and Riascos, Roy F. and Pasternak, Ofer and Wood, Scott J. and Bloomberg, Jacob and Mulavara, Ajitkumar P. and Seidler, Rachael D. (2020) The Impact of 6 and 12 Months in Space on Human Brain Structure and Intracranial Fluid Shifts. Cerebral Cortex Communications, 1 (1), tgaa023. Oxford University Press. doi: 10.1093/texcom/tgaa023. ISSN 2632-7376.
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Official URL: https://academic.oup.com/cercorcomms/article/1/1/tgaa023/5857115
Abstract
As plans develop for Mars missions, it is important to understand how long-duration spaceflight impacts brain health. Here we report how 12-month (n = 2 astronauts) versus 6-month (n = 10 astronauts) missions impact brain structure and fluid shifts. We collected MRI scans once before flight and four times after flight. Astronauts served as their own controls; we evaluated pre- to postflight changes and return toward preflight levels across the 4 postflight points. We also provide data to illustrate typical brain changes over 7 years in a reference dataset. Twelve months in space generally resulted in larger changes across multiple brain areas compared with 6-month missions and aging, particularly for fluid shifts. The majority of changes returned to preflight levels by 6 months after flight. Ventricular volume substantially increased for 1 of the 12-month astronauts (left: +25%, right: +23%) and the 6-month astronauts (left: 17 ± 12%, right: 24 ± 6%) and exhibited little recovery at 6 months. Several changes correlated with past flight experience; those with less time between subsequent missions had larger preflight ventricles and smaller ventricular volume increases with flight. This suggests that spaceflight-induced ventricular changes may endure for long periods after flight. These results provide insight into brain changes that occur with longduration spaceflight and demonstrate the need for closer study of fluid shifts
Item URL in elib: | https://elib.dlr.de/135965/ | ||||||||||||||||||||||||||||||||||||||||||
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Document Type: | Article | ||||||||||||||||||||||||||||||||||||||||||
Title: | The Impact of 6 and 12 Months in Space on Human Brain Structure and Intracranial Fluid Shifts | ||||||||||||||||||||||||||||||||||||||||||
Authors: |
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Date: | 15 June 2020 | ||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Cerebral Cortex Communications | ||||||||||||||||||||||||||||||||||||||||||
Refereed publication: | Yes | ||||||||||||||||||||||||||||||||||||||||||
Open Access: | Yes | ||||||||||||||||||||||||||||||||||||||||||
Gold Open Access: | Yes | ||||||||||||||||||||||||||||||||||||||||||
In SCOPUS: | No | ||||||||||||||||||||||||||||||||||||||||||
In ISI Web of Science: | No | ||||||||||||||||||||||||||||||||||||||||||
Volume: | 1 | ||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1093/texcom/tgaa023 | ||||||||||||||||||||||||||||||||||||||||||
Page Range: | tgaa023 | ||||||||||||||||||||||||||||||||||||||||||
Publisher: | Oxford University Press | ||||||||||||||||||||||||||||||||||||||||||
ISSN: | 2632-7376 | ||||||||||||||||||||||||||||||||||||||||||
Status: | Published | ||||||||||||||||||||||||||||||||||||||||||
Keywords: | cortical thickness, free water, gray matter volume, spaceflight, ventricular volume | ||||||||||||||||||||||||||||||||||||||||||
HGF - Research field: | Aeronautics, Space and Transport | ||||||||||||||||||||||||||||||||||||||||||
HGF - Program: | Space | ||||||||||||||||||||||||||||||||||||||||||
HGF - Program Themes: | Research under Space Conditions | ||||||||||||||||||||||||||||||||||||||||||
DLR - Research area: | Raumfahrt | ||||||||||||||||||||||||||||||||||||||||||
DLR - Program: | R FR - Research under Space Conditions | ||||||||||||||||||||||||||||||||||||||||||
DLR - Research theme (Project): | R - Vorhaben Systemphysiologie (old) | ||||||||||||||||||||||||||||||||||||||||||
Location: | Köln-Porz | ||||||||||||||||||||||||||||||||||||||||||
Institutes and Institutions: | Institute of Aerospace Medicine > Muscle and Bone Metabolism | ||||||||||||||||||||||||||||||||||||||||||
Deposited By: | Arndt, Carina | ||||||||||||||||||||||||||||||||||||||||||
Deposited On: | 08 Sep 2020 13:12 | ||||||||||||||||||||||||||||||||||||||||||
Last Modified: | 19 Dec 2020 04:12 |
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