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Neural Correlates of Vestibular Processing During a Spaceflight Analog With Elevated Carbon Dioxide (CO₂): A Pilot Study

Hupfeld, Kathleen und Lee, Jessica K. und Gadd, Nichole E. und Kofman, Igor S. und De Dios, Yiri E. und Bloomberg, Jacob J. und Mulavara, Ajitkumar P. und Seidler, Rachael D. (2020) Neural Correlates of Vestibular Processing During a Spaceflight Analog With Elevated Carbon Dioxide (CO₂): A Pilot Study. Frontiers in Systems Neuroscience, 13, Seite 80. Frontiers Media S.A.. doi: 10.3389/fnsys.2019.00080. ISSN 1662-5137.

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Offizielle URL: https://www.frontiersin.org/articles/10.3389/fnsys.2019.00080/full

Kurzfassung

Astronauts return to Earth from spaceflight missions with impaired mobility and balance; recovery can last weeks postflight. This is due in large part to the altered vestibular signaling and sensory reweighting that occurs in microgravity. The neural mechanisms of spaceflight-induced vestibular changes are not well understood. Head-down-tilt bed rest (HDBR) is a common spaceflight analog environment that allows for study of body unloading, fluid shifts, and other consequences of spaceflight. Subjects in this context still show vestibular changes despite being in Earth’s gravitational environment, potentially due to sensory reweighting. Previously, we found evidence of sensory reweighting and reduced neural efficiency for vestibular processing in subjects who underwent a 70-day HDBR intervention. Here we extend this work by evaluating the impact of HDBR paired with elevated carbon dioxide (CO₂) to mimic International Space Station conditions on vestibular neural processing. Eleven participants (6 males, 34 ± 8 years) completed 30 days of HDBR combined with 0.5% atmospheric CO₂ (HDBR + CO₂). Participants underwent six functional magnetic resonance imaging (fMRI) sessions pre-, during, and post- HDBR + CO₂ while we measured brain activity in response to pneumatic skull taps (a validated method of vestibular stimulation). We also measured mobility and balance performance several times before and after the intervention. We found support for adaptive neural changes within the vestibular system during bed rest that subsequently recovered in several cortical and cerebellar regions. Further, there were multiple brain regions where greater pre- to post- deactivation was associated with reduced pre- to post- balance declines. That is, increased deactivation of certain brain regions associated with better balance post-HDBR + CO₂. We also found that, compared to HDBR alone (n = 13 males; 29 ± 3 years) HDBR + CO₂ is associated with greater increases in activation of multiple frontal, parietal, and temporal regions during vestibular stimulation. This suggests interactive or additive effects of bed rest and elevated CO₂. Finally, we found stronger correlations between pre- to postHDBR + CO₂ brain changes and dependence on the visual system during balance for subjects who developed signs of Spaceflight-Associated Neuro-ocular Syndrome Frontiers in Systems Neuroscience | www.frontiersin.org 1 January 2020 | Volume 13 | Article 80Hupfeld et al. Neural Vestibular Processing With HDBR + CO₂ (SANS). Together, these findings have clear implications for understanding the neural mechanisms of bed rest and spaceflight-related changes in vestibular processing, as well as adaptation to altered sensory inputs.

elib-URL des Eintrags:https://elib.dlr.de/135896/
Dokumentart:Zeitschriftenbeitrag
Titel:Neural Correlates of Vestibular Processing During a Spaceflight Analog With Elevated Carbon Dioxide (CO₂): A Pilot Study
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Hupfeld, KathleenDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United StatesNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Lee, Jessica K.German Aerospace Center, Institute of Aerospace Medicine, Cologne, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Gadd, Nichole E.KBR, Houston, TX, United StatesNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Kofman, Igor S.KBR, Houston, TX, United StatesNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
De Dios, Yiri E.KBR, Houston, TX, United StatesNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Bloomberg, Jacob J.NASA Johnson Space Center, Houston, TX, United StatesNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Mulavara, Ajitkumar P.KBR, Houston, TX, United StatesNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Seidler, Rachael D.Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United StatesNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Datum:10 Januar 2020
Erschienen in:Frontiers in Systems Neuroscience
Referierte Publikation:Ja
Open Access:Ja
Gold Open Access:Ja
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:13
DOI:10.3389/fnsys.2019.00080
Seitenbereich:Seite 80
Verlag:Frontiers Media S.A.
ISSN:1662-5137
Status:veröffentlicht
Stichwörter:vestibular, fMRI, head-down-tilt bed rest (HDBR), carbon dioxide (CO₂), spaceflight
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Vorhaben Systemphysiologie (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Muskel- und Knochenstoffwechsel
Hinterlegt von: Arndt, Carina
Hinterlegt am:08 Sep 2020 12:58
Letzte Änderung:30 Sep 2020 09:36

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