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Head Down Tilt Bed Rest Plus Elevated CO2 as a Spaceflight Analog: Effects on Cognitive and Sensorimotor Performance

Lee, Jessica K. and De Dios, Yiri and Kofman, Igor and Mulavara, Ajitkumar P. and Bloomberg, Jacob and Seidler, Rachael D. (2019) Head Down Tilt Bed Rest Plus Elevated CO2 as a Spaceflight Analog: Effects on Cognitive and Sensorimotor Performance. Frontiers in Human Neuroscience, 13, p. 355. Frontiers Media S.A.. doi: 10.3389/fnhum.2019.00355. ISSN 1662-5161.

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Official URL: https://www.frontiersin.org/articles/10.3389/fnhum.2019.00355/full#h4

Abstract

Long duration head down tilt bed rest (HDBR) has been widely used as a spaceflight analog environment to understand the effects of microgravity on human physiology and performance. Reports have indicated that crewmembers onboard the International Space Station (ISS) experience symptoms of elevated CO2 such as headaches at lower levels of CO2 than levels at which symptoms begin to appear on Earth. This suggests there may be combinatorial effects of elevated CO2 and the other physiological effects of microgravity including headward fluid shifts and body unloading. The purpose of the current study was to investigate these effects by evaluating the impact of 30 days of 6◦ HDBR and 0.5% CO2 (HDBR C CO2) on mission relevant cognitive and sensorimotor performance. We found a facilitation of processing speed and a decrement in functional mobility for subjects undergoing HDBR C CO2 relative to our previous study of HDBR in ambient air. In addition, nearly half of the participants in this study developed signs of Spaceflight Associated Neuro-ocular Syndrome (SANS), a constellation of ocular structural and functional changes seen in approximately one third of long duration astronauts. This allowed us the unique opportunity to compare the two subgroups. We found that participants who exhibited signs of SANS became more visually dependent and shifted their speed-accuracy tradeoff, such that they were slower but more accurate than those that did not incur ocular changes. These small subgroup findings suggest that SANS may have an impact on mission relevant performance inflight via sensory reweighting. NEW AND NOTEWORTHY We examined the effects of long duration head down tilt bed rest coupled with elevated CO2 as a spaceflight analog environment on human cognitive and sensorimotor performance. We found enhancements in processing speed and declines in functional Frontiers in Human Neuroscience | www.frontiersin.org 1 October 2019 | Volume 13 | Article 355Lee et al. Spaceflight Analog Effects on Behavior mobility. A subset of participants exhibited signs of Spaceflight Associated Neuroocular Syndrome (SANS), which affects approximately one in three astronauts. These individuals increased their visual reliance throughout the intervention in comparison to participants who did not show signs of SANS

Item URL in elib:https://elib.dlr.de/135895/
Document Type:Article
Title:Head Down Tilt Bed Rest Plus Elevated CO2 as a Spaceflight Analog: Effects on Cognitive and Sensorimotor Performance
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Lee, Jessica K.German Aerospace Center, Cologne, GermanyUNSPECIFIED
De Dios, YiriKBRWyle, Houston, TX, United StatesUNSPECIFIED
Kofman, IgorKBRWyle, Houston, TX, United StatesUNSPECIFIED
Mulavara, Ajitkumar P.KBRWyle, Houston, TX, United StatesUNSPECIFIED
Bloomberg, JacobNASA, Johnson Space CenterUNSPECIFIED
Seidler, Rachael D.Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL, United StatesUNSPECIFIED
Date:2019
Journal or Publication Title:Frontiers in Human Neuroscience
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:13
DOI :10.3389/fnhum.2019.00355
Page Range:p. 355
Publisher:Frontiers Media S.A.
ISSN:1662-5161
Status:Published
Keywords:cognition, sensorimotor, CO2, bed rest, spaceflight, SANS (Spaceflight Associated Neuro-ocular Syndrome)
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Arndt, Carina
Deposited On:08 Sep 2020 12:46
Last Modified:30 Sep 2020 14:38

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