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Deciphering the neural signature of human cardiovascular regulation

Manuel, J. and Färber, N. and Gerlach, D.A. and Heusser, K. and Jordan, J. and Tank, J. and Beissner, F. (2020) Deciphering the neural signature of human cardiovascular regulation. eLife, 9, e55316. eLife Sciences Publications. doi: 10.7554/eLife.55316. ISSN 2050-084X.

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Official URL: https://elifesciences.org/articles/55316

Abstract

Cardiovascular regulation is integral to life. Animal studies have identified both neural and endocrine pathways, by which the central nervous system adjusts cardiac output and peripheral vascular resistance to changing physiological demands. The outflow of these pathways is coordinated by various central nervous regions based on afferent information from baroreceptors, chemoreceptors, nociceptors, and circulating hormones, and is modulated by physiologic and behavioural state. In humans, however, knowledge on central cardiovascular regulation below the cortical level is scarce. Here, we show using functional MRI (fMRI) that at least three hypothalamic subsystems are involved in cardiovascular regulation in humans. The rhythmic behaviour of these systems corresponds to high and low frequency oscillations typically seen in blood pressure and heart rate variability.

Item URL in elib:https://elib.dlr.de/135820/
Document Type:Article
Title:Deciphering the neural signature of human cardiovascular regulation
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Manuel, J.Institute for Neuroradiology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Färber, N.Somatosensory and Autonomic Therapy Research, Institute for Neuroradiology, Hannover Medical School, Hanover, GermanyUNSPECIFIED
Gerlach, D.A.darius.gerlach (at) dlr.dehttps://orcid.org/0000-0001-7044-6065
Heusser, K.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Tank, J.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Tank (at) dlr.dehttps://orcid.org/0000-0002-5672-1187
Beissner, F.Institute for Neuroradiology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Date:28 July 2020
Journal or Publication Title:eLife
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:9
DOI :10.7554/eLife.55316
Page Range:e55316
Publisher:eLife Sciences Publications
ISSN:2050-084X
Status:Published
Keywords:autonomic nervous system; brainstem; cardiovascular regulation; fMRI; human; human biology; hypothalamus; medicine; neuroscience
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:01 Sep 2020 13:17
Last Modified:19 Feb 2021 11:28

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