DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Sleeping with Elevated Upper Body Does Not Attenuate Acute Mountain Sickness: Pragmatic Randomized Clinical Trial

Limper, U. and Fiala, V. and Tank, J. and Elmenhorst, E.-M. and Schaelte, G. and Hew, Y.M. and Gauger, P. and Martus, P. and Jordan, J. (2020) Sleeping with Elevated Upper Body Does Not Attenuate Acute Mountain Sickness: Pragmatic Randomized Clinical Trial. The American Journal of Medicine, 133 (10), e584-e588. Elsevier. doi: 10.1016/j.amjmed.2020.01.024. ISSN 0002-9343.

Full text not available from this repository.

Official URL: https://doi.org/10.1016/j.amjmed.2020.01.024


PURPOSE: Acute mountain sickness commonly occurs following ascent to high altitude and is aggravated following sleep. Cephalad fluid shifts have been implicated. We hypothesized that sleeping with the upper body elevated by 30º reduces the risk of acute mountain sickness. METHODS: In a pragmatic, randomized, observer-blinded field study at 4554 meters altitude, we investigated 134 adults aged 18-70 years with a Lake Louise score between 3 and 12 points on the evening of their arrival at the altitude. The individuals were exposed to sleeping on an inflatable cushion elevating the upper body by 30º or on a sham pillow in a horizontal position. The primary endpoint was the change in the Acute Mountain Sickness-Cerebral (AMS-C) score in the morning after sleeping at an altitude of 4554 meters compared with the evening before. Sleep efficiency was the secondary endpoint. RESULTS: Among 219 eligible mountaineers, 134 fulfilled the inclusion criteria and were randomized. The AMS-C score increased by 0.250 ± 0.575 in the control group and by 0.121 ± 0.679 in the intervention group (difference 0.105; 95% confidence interval, -0.098-0.308; P = .308). Oxygen saturation in the morning was 79% ± 6% in the intervention group and 78% ± 6% in the control group (P = .863). Sleep efficiency did not differ between groups (P = .115). CONCLUSIONS: Sleeping with the upper body elevated by 30° does not lead to relevant reductions in acute mountain sickness symptoms or hypoxemia at high altitude.

Item URL in elib:https://elib.dlr.de/134754/
Document Type:Article
Title:Sleeping with Elevated Upper Body Does Not Attenuate Acute Mountain Sickness: Pragmatic Randomized Clinical Trial
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Limper, U.UNSPECIFIEDhttps://orcid.org/0000-0001-9927-4180UNSPECIFIED
Tank, J.German Aerospace Center, Institute of Aerospace Medicinehttps://orcid.org/0000-0002-5672-1187UNSPECIFIED
Elmenhorst, E.-M.UNSPECIFIEDhttps://orcid.org/0000-0003-0336-6705UNSPECIFIED
Schaelte, G.Department of Anesthesiology, Medical Faculty, University Hospital RWTH Aachen, Aachen, GermanyUNSPECIFIEDUNSPECIFIED
Hew, Y.M.German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Gauger, P.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIEDUNSPECIFIED
Martus, P.Institute of Medical Biometry, University of Tuebingen, Tuebingen, GermanyUNSPECIFIEDUNSPECIFIED
Jordan, J.UNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Date:17 February 2020
Journal or Publication Title:The American Journal of Medicine
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
Page Range:e584-e588
Keywords:Acute mountain sickness; Altitude; Brain edema; Environmental medicine; High altitude; Mountaineering; Pulmonary; Sleep; Travel medicine
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Leitungsbereich ME
Institute of Aerospace Medicine > Sleep and Human Factors Research
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Schrage, Larissa
Deposited On:29 Apr 2020 11:01
Last Modified:23 Oct 2023 13:05

Repository Staff Only: item control page

Help & Contact
electronic library is running on EPrints 3.3.12
Website and database design: Copyright © German Aerospace Center (DLR). All rights reserved.