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Orthostatic Hypertension: Critical Appraisal of an Overlooked Condition

Jordan, J. and Ricci, F. and Hoffmann, F. and Hamrefors, V. and Fedorowski, A. (2020) Orthostatic Hypertension: Critical Appraisal of an Overlooked Condition. Hypertension, 75 (5), pp. 1151-1158. American Heart Association, Inc.. doi: 10.1161/HYPERTENSIONAHA.120.14340. ISSN 0194-911X.

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Official URL: https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.14340

Abstract

Orthostatic hypertension, which appears to be mediated through excess neurohumoral activation while standing, is a common blood pressure trait among patients with and without arterial hypertension. However, lack of consensus regarding the definition of orthostatic hypertension makes it difficult to assess the true prevalence of this condition. Orthostatic hypertension appears to predict the risk for progression to arterial hypertension in younger and risk of cardiovascular morbidity and mortality in older persons. Yet, the risk may differ between populations. Whether orthostatic hypertension indicates a generally increased risk of death, constitutes an intermediate variable in the causal pathway of cardiovascular risk factors, a simple measure of disease severity, or an independently acting mechanism is not known. Since both orthostatic hypotension and orthostatic hypertension herald increased risk of cardiovascular disease, it appears reasonable to screen the patients for abnormal orthostatic blood pressure responses using simple orthostatic testing. However, how presence of orthostatic hypertension may affect clinical management decisions such as the choice of antihypertensive drugs is currently difficult to ascertain. Clearly, this issue deserves more attention.

Item URL in elib:https://elib.dlr.de/134747/
Document Type:Article
Title:Orthostatic Hypertension: Critical Appraisal of an Overlooked Condition
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Ricci, F.Department of Clinical Sciences, Lund University, Malmö, SwedenUNSPECIFIED
Hoffmann, F.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.;Department of Cardiology, Pneumology, and Angiology, Heart Center of the University of Cologne, GermanyUNSPECIFIED
Hamrefors, V.Department of Clinical Sciences, Lund University, Malmö, SwedenUNSPECIFIED
Fedorowski, A.Department of Clinical Sciences, Lund University, Malmö, SwedenUNSPECIFIED
Date:30 March 2020
Journal or Publication Title:Hypertension
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:75
DOI :10.1161/HYPERTENSIONAHA.120.14340
Page Range:pp. 1151-1158
Publisher:American Heart Association, Inc.
ISSN:0194-911X
Status:Published
Keywords:baroreflex; blood pressure; cardiovascular system; orthostatic hypertension; standing position
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:29 Apr 2020 11:08
Last Modified:30 Sep 2020 09:51

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