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Diegeler, S. and Kronenberg, J. and Schmitz, C. and Hellweg, C.E. and Mulder, E. and Bohmeier, M. and Schrage-Knoll, I. and Kraus, G. and Huth, E. and Berwanger, C. and Paulke, F. and Lecheler, L. and Jordan, J (2020) DNA DOUBLE STRAND REPAIR DURING HEAD-DOWN-TILT BEDREST: AGBRESA MEETS RADIATION. The 2020 Human Research Program Investigators’ Workshop (HRP IWS 2020), 27.-30. Januar 2020, Galveston Island Convention Center (GICC) in Galveston, Texas.
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Abstract
BACKGROUND Radiation and reduced gravity impose a major burden on health and performance during human spaceflight. While radiation increases cancer risk and limits tissue regeneration, reduced gravity predisposes to musculoskeletal and cardiovascular deconditioning. Deconditioning could conceivably limit the recovery from radiation damage. Our aim was to develop a terrestrial ex vivo model that could be utilized to study the interaction between simulated reduced gravity using head-down-tilt bed rest and radiation on cellular DNA repair.
| Item URL in elib: | https://elib.dlr.de/134254/ | ||||||||||||||||||||||||||||||||||||||||||
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| Document Type: | Conference or Workshop Item (Speech) | ||||||||||||||||||||||||||||||||||||||||||
| Title: | DNA DOUBLE STRAND REPAIR DURING HEAD-DOWN-TILT BEDREST: AGBRESA MEETS RADIATION | ||||||||||||||||||||||||||||||||||||||||||
| Authors: |
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| Date: | 27 January 2020 | ||||||||||||||||||||||||||||||||||||||||||
| Refereed publication: | Yes | ||||||||||||||||||||||||||||||||||||||||||
| Open Access: | Yes | ||||||||||||||||||||||||||||||||||||||||||
| Gold Open Access: | No | ||||||||||||||||||||||||||||||||||||||||||
| In SCOPUS: | No | ||||||||||||||||||||||||||||||||||||||||||
| In ISI Web of Science: | No | ||||||||||||||||||||||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||||||||||||||||||||||
| Keywords: | human spaceflight, AGBRESA study, simulated reduced gravity, radiation, head-down-tilt bed rest, DNA repair | ||||||||||||||||||||||||||||||||||||||||||
| Event Title: | The 2020 Human Research Program Investigators’ Workshop (HRP IWS 2020) | ||||||||||||||||||||||||||||||||||||||||||
| Event Location: | Galveston Island Convention Center (GICC) in Galveston, Texas | ||||||||||||||||||||||||||||||||||||||||||
| Event Type: | international Conference | ||||||||||||||||||||||||||||||||||||||||||
| Event Dates: | 27.-30. Januar 2020 | ||||||||||||||||||||||||||||||||||||||||||
| HGF - Research field: | Aeronautics, Space and Transport | ||||||||||||||||||||||||||||||||||||||||||
| HGF - Program: | Space | ||||||||||||||||||||||||||||||||||||||||||
| HGF - Program Themes: | Research under Space Conditions | ||||||||||||||||||||||||||||||||||||||||||
| DLR - Research area: | Raumfahrt | ||||||||||||||||||||||||||||||||||||||||||
| DLR - Program: | R FR - Research under Space Conditions | ||||||||||||||||||||||||||||||||||||||||||
| DLR - Research theme (Project): | R - Vorhaben Strahlenbiologie (old) | ||||||||||||||||||||||||||||||||||||||||||
| Location: | Köln-Porz | ||||||||||||||||||||||||||||||||||||||||||
| Institutes and Institutions: | Institute of Aerospace Medicine > Radiation Biology Institute of Aerospace Medicine > Muscle and Bone Metabolism Institute of Aerospace Medicine > Leitungsbereich ME | ||||||||||||||||||||||||||||||||||||||||||
| Deposited By: | Kopp, Kerstin | ||||||||||||||||||||||||||||||||||||||||||
| Deposited On: | 03 Mar 2020 12:55 | ||||||||||||||||||||||||||||||||||||||||||
| Last Modified: | 03 Mar 2020 12:55 |
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