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DNA DOUBLE STRAND REPAIR DURING HEAD-DOWN-TILT BEDREST: AGBRESA MEETS RADIATION

Diegeler, S. and Kronenberg, J. and Schmitz, C. and Hellweg, C.E. and Mulder, E. and Bohmeier, M. and Schrage-Knoll, I. and Kraus, G. and Huth, E. and Berwanger, C. and Paulke, F. and Lecheler, L. and Jordan, J (2020) DNA DOUBLE STRAND REPAIR DURING HEAD-DOWN-TILT BEDREST: AGBRESA MEETS RADIATION. The 2020 Human Research Program Investigators’ Workshop (HRP IWS 2020), 27.-30. Januar 2020, Galveston Island Convention Center (GICC) in Galveston, Texas.

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Abstract

BACKGROUND Radiation and reduced gravity impose a major burden on health and performance during human spaceflight. While radiation increases cancer risk and limits tissue regeneration, reduced gravity predisposes to musculoskeletal and cardiovascular deconditioning. Deconditioning could conceivably limit the recovery from radiation damage. Our aim was to develop a terrestrial ex vivo model that could be utilized to study the interaction between simulated reduced gravity using head-down-tilt bed rest and radiation on cellular DNA repair.

Item URL in elib:https://elib.dlr.de/134254/
Document Type:Conference or Workshop Item (Speech)
Title:DNA DOUBLE STRAND REPAIR DURING HEAD-DOWN-TILT BEDREST: AGBRESA MEETS RADIATION
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Diegeler, S.Radiation Biology Department, German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne; sebastian.diegeler (at) dlr.deUNSPECIFIED
Kronenberg, J.Radiation Biology Department, German Aerospace Center (DLR), Institute of Aerospace Medicine, CologneUNSPECIFIED
Schmitz, C.Radiation Biology Department, German Aerospace Center (DLR), Institute of Aerospace Medicine, CologneUNSPECIFIED
Hellweg, C.E.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Christine.Hellweg (at) dlr.dehttps://orcid.org/0000-0002-2223-3580
Mulder, E.Edwin.Mulder (at) dlr.deUNSPECIFIED
Bohmeier, M.Muscle and Bone Metabolism Department, DLR, Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Schrage-Knoll, I.Muscle and Bone Metabolism Department, DLR, Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Kraus, G.Muscle and Bone Metabolism Department, DLR, Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Huth, E.Muscle and Bone Metabolism Department, DLR, Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Berwanger, C.Muscle and Bone Metabolism Department, DLR, Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Paulke, F.Study Team, DLR, Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Lecheler, L.Study Team, DLR, Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Jordan, JInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Date:27 January 2020
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:human spaceflight, AGBRESA study, simulated reduced gravity, radiation, head-down-tilt bed rest, DNA repair
Event Title:The 2020 Human Research Program Investigators’ Workshop (HRP IWS 2020)
Event Location:Galveston Island Convention Center (GICC) in Galveston, Texas
Event Type:international Conference
Event Dates:27.-30. Januar 2020
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Institute of Aerospace Medicine > Muscle and Bone Metabolism
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Kopp, Kerstin
Deposited On:03 Mar 2020 12:55
Last Modified:03 Mar 2020 12:55

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