Relation of muscular contractions to mechanical deformation in the human tibia during different locomotive activities

Kurzfassung

As one of the major hard tissue in humans and most vertebrates, the skeleton, generally referring to bone, provides the essential frame to support the body and to thus permit locomotion. Considering the functional requirements of bones across different species, e.g. from rats to dinosaurs, or during different growth periods, e.g. from embryo to old age, it is not difficult to conceive that bones adapt to the experienced mechanical environment. In fact, mechanically regulated bone modeling and remodeling is one of the major means to maintain regular bone metabolism. The findings on the bone adaptation to the mechanical environment have been well theorized by Julius Wolff in 1890s [1] as ‘Wolff’s law’ and refined later by Harold Frost as ‘mechanostat’ [2-4]. Evidence from numerous animal studies in the past revealed the adaptation process of the bones to the well-defined artificial mechanical environment and suggested certain relationship between the adaptation in relation to the types of loading, e.g. loading amplitude, loading cycle, loading frequency and so on [5-8]. Conversely, bone degradation was generally observed during disuse, e.g. prolonged bed rest [9], or in the microgravity environment during space flight [10]. Indeed, the best way to further our understanding in this adaptation process is to quantitatively study the mechanical loading on bone during daily locomotor activities. However, this is still rather challenging due to technical difficulties. More importantly, the mechanical load on bones can vary greatly across individuals or species, as the variance between the body size, locomotor pattern and speed.