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Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls. Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure

Lüscher, S.H. and Nocciolino, L.M. and Pilot, N. and Pisani, L. and Ireland, A. and Rittweger, Jörn and Ferretti, J.L. and Cointry, G.R. and Capozza, RF. (2019) Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls. Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure. Frontiers in Endocrinology. Frontiers Media S.A.. DOI: 10.3389/fendo.2019.00833 ISSN 1664-2392

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/?term=Differences+in+the+Cortical+Structure+of+the+Whole+Fibula+and+Tibia+between+Long-Distance+Runners+and+Untrained+Controls

Abstract

The cortical structure of human fibula varies widely throughout the bone suggesting a more selective adaptation to different mechanical environments with respect to the adjacent tibia. To test this hypothesis, serial-pQCT scans of the dominant fibulae and tibiae of 15/15 men/women chronically trained in long-distance running were compared with those of 15/15 untrained controls. When compared to controls, the fibulae of trained individuals had similar (distally) or lower (proximally) cortical area, similar moments of inertia (MI) for anterior-posterior bending (xMI) and lower for lateral bending (yMI) with a lower "shape-index" (yMI/xMI ratio) throughout, and higher resistance to buckling distally. These group differences were more evident in men and independent of group differences in bone mass. These results contrast with those observed in the tibia, where, as expected, structural indicators of bone strength were greater in trained than untrained individuals. Proximally, the larger lateral flexibility of runners' fibulae could improve the ability to store energy, and thereby contribute to fast-running optimization. Distally, the greater lateral fibular flexibility could reduce bending strength. The latter appears to have been compensated by a higher buckling strength. Assuming that these differences could be ascribed to training effects, this suggests that usage-derived strains in some bones may modify their relative structural resistance to different kinds of deformation in different regions, not only regarding strength, but also concerning other physiological roles of the skeleton.

Item URL in elib:https://elib.dlr.de/133750/
Document Type:Article
Title:Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls. Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Lüscher, S.H.UNSPECIFIEDUNSPECIFIED
Nocciolino, L.M.CEMFoCUNSPECIFIED
Pilot, N.UNSPECIFIEDUNSPECIFIED
Pisani, L.UNSPECIFIEDUNSPECIFIED
Ireland, A.Manchester Metropolitan UniversityUNSPECIFIED
Rittweger, JörnInstitute of Aerospace Medicine, Deutsches Zentrum für Luft- und Raumfahrt, DLR e.V., Cologne, Germany and Medical Faculty, University of Cologne, Cologne, Germany; joern.rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Ferretti, J.L.Center of P-Ca Metabolism Studies (CEMFoC), jlferretti (at) arnet.com.arUNSPECIFIED
Cointry, G.R.National University of RosarioUNSPECIFIED
Capozza, RF.UNSPECIFIEDUNSPECIFIED
Date:27 October 2019
Journal or Publication Title:Frontiers in Endocrinology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI :10.3389/fendo.2019.00833
Publisher:Frontiers Media S.A.
ISSN:1664-2392
Status:Published
Keywords:Cortical Structure; structural indicators of bone strength; lateral fibular flexibility; Biomechanical Regulation
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:21 Jan 2020 11:26
Last Modified:21 Jan 2020 11:28

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