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The LunHab project: Muscle and bone alterations in male participants following a 10 day lunar habitat simulation

McDonnell, Adam C. and Eiken, Ola and Frings-Meuthen, Petra and Rittweger, Jörn and Mekjavic, Igor B. (2019) The LunHab project: Muscle and bone alterations in male participants following a 10 day lunar habitat simulation. Experimental Physiology, pp. 1250-1261. Wiley. DOI: 10.1113/EP087482 ISSN 0958-0670

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Official URL: http://wileyonlinelibrary.com/journal/eph

Abstract

Musculoskeletal atrophy constitutes a typical adaptation to inactivity and unloading of weightbearing bones. The reduced-gravity environment in future Moon and Mars habitats is likely to be hypobaric hypoxic, and there is an urgent need to understand the effect of hypoxia on the process of inactivity-induced musculoskeletal atrophy. This was the principal aim of the present study. Eleven males participated in three 10 day interventions: (i) hypoxic ambulatory confinement; (ii) hypoxic bed rest; and (iii) normoxic bed rest. Before and after the interventions, the muscle strength (isometric maximal voluntary contraction), mass (lean mass, by dual-energy X-ray absorptiometry), cross-sectional area and total bone mineral content (determined with peripheral quantitative computed tomography) of the participants were measured. Blood and urine samples were collected before and on the 1st, 4th and 10th day of the intervention and analysed for biomarkers of bone resorption and formation. There was a significant reduction in thigh and lower leg muscle mass and volume after both normoxic and hypoxic bed rests. Muscle strength loss was proportionately greater than the loss in muscle mass for both thigh and lower leg. There was no indication of bone loss. Furthermore, the biomarkers of resorption and formation were not affected by any of the interventions. There was no significant effect of hypoxia on the musculoskeletal variables. Short-term normoxic (10 day) bed rest resulted in muscular deconditioning, but not in the loss of bone mineral content or changes in bone metabolism. Hypoxia did not modify these results.

Item URL in elib:https://elib.dlr.de/133719/
Document Type:Article
Title:The LunHab project: Muscle and bone alterations in male participants following a 10 day lunar habitat simulation
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
McDonnell, Adam C.Department of Automation, BiocyberneticsUNSPECIFIED
Eiken, OlaDepartment of Environmental Physiology, Swedish Aerospace Physiology Centre, Royal Institute of Technology, Stockholm, SwedenUNSPECIFIED
Frings-Meuthen, PetraPetra.Frings-Meuthen (at) dlr.deUNSPECIFIED
Rittweger, JörnJoern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Mekjavic, Igor B.Jozef Stefan InstituteUNSPECIFIED
Date:10 April 2019
Journal or Publication Title:Experimental Physiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI :10.1113/EP087482
Page Range:pp. 1250-1261
Publisher:Wiley
ISSN:0958-0670
Status:Published
Keywords:bed rest, bone, hypoxia, muscle
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:22 Jan 2020 09:26
Last Modified:22 Jan 2020 09:26

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