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NEUROMUSCULAR AND MYOTENDINOUS ALTERATIONS IN-FLIGHT IN PLANTAR FLEXOR MUSCLES

Rittweger, Jörn and Tomilovskaya, E.S. and Albracht, Kirsten and Bottinelli, Roberto and Capri, Miriam and Cerretelli, Paolo and Clarke, Mark and Flück, Martin and Franceschi, Claudio and Gelfi, Cecilia and Koryak, Yuri and Layne, Charles and Narici, Marco and Reed, Jonathan and Shenkmann, Boris and Sies, Wolfram (Admin.), Funktional and Stäudle, Benjamin and Laughlin, Mitzi (2019) NEUROMUSCULAR AND MYOTENDINOUS ALTERATIONS IN-FLIGHT IN PLANTAR FLEXOR MUSCLES. NASA Human Research Program Investigator's Workshop, 22.-25.1.2019, Galveston, Texas.

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Abstract

BACKGROUND Despite extensive exercise countermeasures, astronauts still experience sizable deficits in calf muscle mass and strength. Recent muscle biopsy data suggest deficits are associated with metabolic deviations [1]. Many studies have tested astronaut strength before and after spaceflight. The one study that tested in-flight reported a significant reduction in isometric and isokinetic knee extensor strength that was pronounced from the very beginning of the space sojourn [2]. This is in stark contrast to bed rest studies, where a gradual and continuous loss of muscle mass and strength has been repeatedly reported. METHODS The Sarcolab3 study attempted to describe the time course of changes in isometric and isokinetic muscle strength and in muscle mass. Crew members were tested on board the ISS after 8.9 (SD 3.0), 49.1 (10.1) and 131.5 (SD 27.7) days in-flight, as well as pre-and post-flight, using the Muscle Atrophy Research and Exercise System (MARES). Specifically, maximal voluntary torques in plantar flexion and knee extension were measured at various angles in order to establish the torque-angle relationship. Simultaneously, activation capacity was assessed by supra-maximal myo-electrical stimulation superimposed to a maximum voluntary contraction. Calf muscle volume was assessed by magnetic resonance imaging pre-and post-flight. RESULTS Results demonstrate early declines in muscle strength at flight days 9 and 49, and a tendency for the decaying time course to level off at flight day 131. Activation capacity of plantar flexor, as elicited by myo-electrical stimulation, was maintained during in-flight and post-flight testing. At 4 days post-flight, soleus muscle volume had declined by 15-20% as compared to pre-flight. CONCLUSIONS Results suggest that existing exercise countermeasures are still not fully effective for preventing weakness and wasting of the calf musculature. The observed time course of in-flight muscle loss seems more compatible with results from bed rest. Potentially, the rate of muscle wasting may decline during the second half of 6-month missions with the current countermeasure exercise regimens. REFERENCES 1. Rittweger, J., et al., Sarcolab pilot study into skeletal muscle's adaptation to long-term spaceflight. NPJ Microgravity, 2018. 4: p. 18. 2. Tschan, H., et al., Resistance training - a strategy proposed to coutneract muscular deconditioning in microgravity, in 10 Years Space Biomedical Research and Development in Austria, H. Hinghofer-Szalkay, Editor. 2001, Facultas: Wien. p. 95-108.

Item URL in elib:https://elib.dlr.de/133494/
Document Type:Conference or Workshop Item (Poster)
Title:NEUROMUSCULAR AND MYOTENDINOUS ALTERATIONS IN-FLIGHT IN PLANTAR FLEXOR MUSCLES
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Rittweger, JörnJoern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Tomilovskaya, E.S.Institute of Biomedical Problems, Russian Academy of SciencesUNSPECIFIED
Albracht, KirstenGerman Sport University Colognehttps://orcid.org/0000-0002-4271-2511
Bottinelli, RobertoUniversity of PaviaUNSPECIFIED
Capri, MiriamDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italyhttps://orcid.org/0000-0001-9077-0401
Cerretelli, PaoloUniversity MilanUNSPECIFIED
Clarke, MarkUniversity of HoustonUNSPECIFIED
Flück, MartinDepartment of Orthopaedics, University of Zürich, Zürich, Switzerlandhttps://orcid.org/0000-0002-0479-7243
Franceschi, ClaudioDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, ItalyUNSPECIFIED
Gelfi, CeciliaUniversity of MilanUNSPECIFIED
Koryak, YuriInstitute of Biomedical Problems, Russian Academy of SciencesUNSPECIFIED
Layne, CharlesUniversity of HoustonUNSPECIFIED
Narici, MarcoDepartment of Biomedical Sciences, University of Padova, Padova, ItalyUNSPECIFIED
Reed, JonathanUniversity of HoustonUNSPECIFIED
Shenkmann, BorisInstitute of Biomedical Problems, Russian Academy of SciencesUNSPECIFIED
Sies, Wolfram (Admin.), Funktionalwolfram.sies (at) dlr.deUNSPECIFIED
Stäudle, BenjaminFachhochschule AachenUNSPECIFIED
Laughlin, MitziUniversity of HoustonUNSPECIFIED
Date:2019
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:Muskel, Schwerelosigkeit
Event Title:NASA Human Research Program Investigator's Workshop
Event Location:Galveston, Texas
Event Type:international Conference
Event Dates:22.-25.1.2019
Organizer:NASA
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Rittweger, Jörn
Deposited On:16 Jan 2020 12:37
Last Modified:16 Jan 2020 12:37

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