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Response of mammalian eye lenses to space radiation qualities in vitro and in organ culture

Konda, Bikash (2019) Response of mammalian eye lenses to space radiation qualities in vitro and in organ culture. Dissertation, Universität des Saarlandes.

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Abstract

The eye lens is known to be a radiosensitive mammalian organ, and ionizing radiation is considered to be a widely known risk factor inducing lens opacities. During space missions, astronauts are constantly exposed to galactic cosmic radiation, which contains energetic heavy ions of high linear energy transfer (LET). Due to higher dose and different patterns of cellular energy deposition from the high-LET ions, astronauts have higher risk for developing cataract compared to low-LET radiation exposure on earth. Although the exact mechanism of opacification is not known in detail, it is hypothesized that it initiates from the post-irradiation proliferative activity of genetically damaged lens epithelial cells. [...]

Item URL in elib:https://elib.dlr.de/133305/
Document Type:Thesis (Dissertation)
Title:Response of mammalian eye lenses to space radiation qualities in vitro and in organ culture
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Konda, BikashRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; bikash.konda (at) dlr.deUNSPECIFIED
Date:August 2019
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Number of Pages:173
Status:Published
Keywords:mammalian eye lens, space radiation
Institution:Universität des Saarlandes
Department:Medizinische Fakultät
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:08 Jan 2020 11:30
Last Modified:08 Jan 2020 11:30

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