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Cardiovascular, renal and liver protection with novel antidiabetic agents beyond blood glucose lowering in type 2 diabetes: consensus article from the European Society of Hypertension Working Group on Obesity, Diabetes and the High-risk Patient

Kotsis, V. and Jordan, J. and Stabouli, S. and Antza, C. and Micic, D. and Jelakovic, B. and Schlaich, M.P. and Nilsson, P.M. and Kreutz, R. and Mancia, G. and Tsioufis, K. and Grassi, G. (2019) Cardiovascular, renal and liver protection with novel antidiabetic agents beyond blood glucose lowering in type 2 diabetes: consensus article from the European Society of Hypertension Working Group on Obesity, Diabetes and the High-risk Patient. Journal of Hypertension. Wolters Kluver Health. DOI: 10.1097/HJH.0000000000002279 ISSN 0263-6352

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Abstract

The prevalence of type 2 diabetes (T2D) has increased over the past few decades. T2D has a strong genetic propensity that becomes overt when a patient is exposed to a typical Western lifestyle, gain weight and becomes obese, whereas weight loss protects from the development of T2D. Except of lifestyle modifications, the choice of the appropriate treatment is essential in the management of patients with T2D and appears critical for the obese population with T2D. The new pharmacological approach for the treatment of T2D, sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists, seems to be effective not only in the management of T2D but also for weight loss, reduction of blood pressure and improvement of nonalcoholic fatty liver disease. Sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 analogues reduced cardiovascular risk, prevented cardiovascular disease and mortality, thereby playing an important role in the treatment of obese patients with hypertension and T2D.

Item URL in elib:https://elib.dlr.de/133082/
Document Type:Article
Title:Cardiovascular, renal and liver protection with novel antidiabetic agents beyond blood glucose lowering in type 2 diabetes: consensus article from the European Society of Hypertension Working Group on Obesity, Diabetes and the High-risk Patient
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Kotsis, V.3rd Department of Internal Medicine, Hypertension-24 h ABPM ESH Center of Excellence, Papageorgiou Hospital, Aristotle University of ThessalonikiUNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Stabouli, S.1st Department of Pediatrics, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreeceUNSPECIFIED
Antza, C.3rd Department of Internal Medicine, Hypertension-24 h ABPM ESH Center of Excellence, Papageorgiou Hospital, Aristotle University of ThessalonikiUNSPECIFIED
Micic, D.Institute for Clinical Pharmacology, Medical School Hannover, Hannover, GermanyUNSPECIFIED
Jelakovic, B.Department of Nephrology, Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, CroatiaUNSPECIFIED
Schlaich, M.P.Dobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit, The University of Western Australia, Perth, Western AustraliaUNSPECIFIED
Nilsson, P.M.Department of Clinical Sciences, Internal Medicine, Skåne University Hospital, Malmö, SwedenUNSPECIFIED
Kreutz, R.Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu BerlinUNSPECIFIED
Mancia, G.University of Milano-Bicocca, Milan, ItalyUNSPECIFIED
Tsioufis, K.First Cardiology Clinic, Medical School, National and Kapodistrian University of Athens Hippokration Hospital, Athens, GreeceUNSPECIFIED
Grassi, G.Clinical Medica, School of Medicine and Surgery, Milano-Bicocca University;IRCCS Multimedica, Sesto San Giovanni, Milan, ItalyUNSPECIFIED
Date:20 November 2019
Journal or Publication Title:Journal of Hypertension
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI :10.1097/HJH.0000000000002279
Publisher:Wolters Kluver Health
ISSN:0263-6352
Status:Published
Keywords:Cardiovascular; anitidiabetic; type 2 Diabetes;
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:07 Jan 2020 12:25
Last Modified:07 Jan 2020 12:25

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