elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Efficacy of electrical baroreflex activation is independent of peripheral chemoreceptor modulation

Heusser, K. and Thöne, A. and Lipp, A. and Menne, J. and Beige, J. and Reuter, H. and Hoffmann, F. and Halbach, M. and Eckert, S. and Wallbach, M. and Koziolek, M. and Haarmann, H. and Joyner, M. and Paton, J.F.R. and Diedrich, A. and Haller, H. and Jordan, J. and Tank, J. (2020) Efficacy of electrical baroreflex activation is independent of peripheral chemoreceptor modulation. Hypertension, 75 (1), pp. 257-264. American Heart Association, Inc.. doi: 10.1161/HYPERTENSIONAHA.119.13925. ISSN 0194-911X.

Full text not available from this repository.

Official URL: https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.13925

Abstract

Arterial baroreflex activation through electrical carotid sinus stimulation has been developed for the treatment of resistant hypertension. Previous studies suggested that the peripheral chemoreflex is tonically active in hypertensive patients and may inhibit baroreflex responses. We hypothesized that peripheral chemoreflex activation attenuates baroreflex efficacy evoked by electrical carotid sinus stimulation. We screened 35 patients with an implanted electrical carotid sinus stimulator. Of those, 11 patients with consistent acute depressor response were selected (7 men/4 women, age: 67±8 years, body mass index: 31.6±5.2 kg/m2, 6±2 antihypertensive drug classes). We assessed responses to electrical baroreflex stimulation during normoxia, isocapnic hypoxia (SpO2: 79.0±1.5%), and hyperoxia (40% end-tidal O2 fraction) by measuring heart rate, blood pressure, ventilation, oxygen saturation, end-tidal CO2 and O2 fractions, and muscle sympathetic nerve activity. During normoxia, baroreflex activation reduced systolic blood pressure from 164±27 to 151±25 mm Hg (mean±SD, P<0.001), heart rate from 64±13 to 61±13 bpm (P=0.002), and muscle sympathetic nerve activity from 42±12 to 36±12 bursts/min (P=0.004). Hypoxia increased systolic blood pressure 8±12 mm Hg (P=0.057), heart rate 10±6 bpm (P<0.001), muscle sympathetic nerve activity 7±7 bursts/min (P=0.031), and ventilation 10±7 L/min (P=0.002). However, responses to electrical carotid sinus stimulation did not differ between hypoxic and hyperoxic conditions: systolic blood pressure: -15±7 versus -14±8 mm Hg (P=0.938), heart rate: -2±3 versus -2±2 bpm (P=0.701), and muscle sympathetic nerve activity: -6±4 versus -4±3 bursts/min (P=0.531). We conclude that moderate peripheral chemoreflex activation does not attenuate acute responses to electrical baroreflex activation therapy in patients with resistant hypertension. These patients provided insight into human baroreflex-chemoreflex interactions that could not be gained otherwise.

Item URL in elib:https://elib.dlr.de/133069/
Document Type:Article
Title:Efficacy of electrical baroreflex activation is independent of peripheral chemoreceptor modulation
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Heusser, K.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIEDUNSPECIFIED
Thöne, A.Clinical Research Center, Hannover Medical School, Hannover, GermanyUNSPECIFIEDUNSPECIFIED
Lipp, A.Department of Neurology, Charité University-Medicine Berlin, Berlin, GermanyUNSPECIFIEDUNSPECIFIED
Menne, J.Department of Nephrology and Hypertension, Hannover Medical School, Hannover, GermanyUNSPECIFIEDUNSPECIFIED
Beige, J.Department of Nephrology and KfH Renal Unit, Hospital St. Georg Leipzig, Leipzig, GermanyUNSPECIFIEDUNSPECIFIED
Reuter, H.Department of Internal Medicine and Cardiology, Evangelisches Klinikum Köln Weyertal, CologneUNSPECIFIEDUNSPECIFIED
Hoffmann, F.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.;Department of Cardiology, Pneumology, and Angiology, Heart Center of the University of Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Halbach, M.Department of Cardiology, Pneumology, and Angiology, Heart Center of the University of Cologne, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Eckert, S.Department of Cardiology, Heart and Diabetes Centre North Rhine-Westphalia, University Hospital, Ruhr University Bochum, Bad Oeynhausen, GermanyUNSPECIFIEDUNSPECIFIED
Wallbach, M.Department of Nephrology & Rheumatology, University Medical Center Göttingen, Göttingen, GermanyUNSPECIFIEDUNSPECIFIED
Koziolek, M.Department of Nephrology & Rheumatology, University Medical Center Göttingen, Göttingen, GermanyUNSPECIFIEDUNSPECIFIED
Haarmann, H.Clinic for Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, GermanyUNSPECIFIEDUNSPECIFIED
Joyner, M.Department of Anesthesiology, Mayo Clinic, Rochester, Rochester, MNUNSPECIFIEDUNSPECIFIED
Paton, J.F.R.School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United KingdomUNSPECIFIEDUNSPECIFIED
Diedrich, A.Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Service, Vanderbilt University, Nashville, TNUNSPECIFIEDUNSPECIFIED
Haller, H.Department of Nephrology and Hypertension, Hannover Medical School, Hannover, GermanyUNSPECIFIEDUNSPECIFIED
Jordan, J.UNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Tank, J.German Aerospace Center, Institute of Aerospace Medicinehttps://orcid.org/0000-0002-5672-1187UNSPECIFIED
Date:January 2020
Journal or Publication Title:Hypertension
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:75
DOI:10.1161/HYPERTENSIONAHA.119.13925
Page Range:pp. 257-264
Publisher:American Heart Association, Inc.
ISSN:0194-911X
Status:Published
Keywords:baroreflex; blood pressure; carotid sinus; hyperoxia; hypoxia
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:07 Jan 2020 12:16
Last Modified:24 Oct 2023 14:20

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Website and database design: Copyright © German Aerospace Center (DLR). All rights reserved.