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Staphylococcus capitis subsp. capitis ISS isolate as a model organism for evaluating antimicrobial surfaces within the upcoming space flight experiment BIOFILMS

Siems, K. and Müller, D. and Mücklich, F. and Grohmann, E. and Laue, M. and Mancinell, R.L. and Krause, J. and Demets, R. and Caplin, N. and Koehler, A. and Tortora, A. and Hemmersbach, R. and Hellweg, C.E. and Moeller, R. (2019) Staphylococcus capitis subsp. capitis ISS isolate as a model organism for evaluating antimicrobial surfaces within the upcoming space flight experiment BIOFILMS. ASGSR 2019, 20.-23-Nov. 2019, Denver, Colorado, USA.

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Abstract

Long-term human missions to space require methods for sustaining the health and safety of the crew. Therefore, microbiological monitoring and reduction of contamination is necessary. Microbial biofilms are of special interest because they can cause damage to spaceflight equipment and are difficult to eliminate due to their increased resistance to antibiotics and disinfectants. The introduction of antimicrobial surfaces for medical, pharmaceutical, and industrial purposes has shown a unique potential for reducing and preventing biofilm formation. The European Space Agency (ESA) launched the BIOFILMS-project, which is evaluating the effect of microgravity on biofilm formation on non-inhibitory surfaces, such as steel, and on antimicrobial metal surfaces. These surfaces are composed out of different metals with and without nanostructures. For the project, human-relevant bacterial strains were selected. One of the selected strains is Staphylococcus capitis subsp. capitis K1-2-2-23, which was isolated from the International Space Station (ISS) on V2A steel and is forming strong biofilms. A comparison of this strain to the DSMZ type strain revealed several differences that include colony pigmentation, increased growth, and tolerance to desiccation. Furthermore, tests with S. capitis subsp. capitis strain K1-2-2-23 within the BIOFILMS hardware revealed that the hardware is biocompatible and allowed biofilm formation on steel surfaces. Additionally, the use of pure copper and brass surfaces inside the hardware led to a significant reduction in growth and biofilm formation, whereby nanostructured copper surfaces were observed to be more effective. The obtained results lay the foundation for the BIOFILMS spaceflight project that will be conducted aboard the International Space Station and may provide suitable antimicrobial surfaces for spaceflight purposes.

Item URL in elib:https://elib.dlr.de/132697/
Document Type:Conference or Workshop Item (Speech)
Title:Staphylococcus capitis subsp. capitis ISS isolate as a model organism for evaluating antimicrobial surfaces within the upcoming space flight experiment BIOFILMS
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Siems, K.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; katharina.siems (at) dlr.deUNSPECIFIED
Müller, D.Department of Materials Science and Engineering, Saarland University, Saarbrücken, GermanyUNSPECIFIED
Mücklich, F.Department of Materials Science and Engineering, Saarland University, Saarbrücken, GermanyUNSPECIFIED
Grohmann, E.Beuth Hochschule für Technik, Fachbereich Life Sciences and Technologie, Berlin, GermanyUNSPECIFIED
Laue, M.RobertKoch Institute (RKI), Advanced Light and Electron Microscopy, Berlin, GermanyUNSPECIFIED
Mancinell, R.L.NASA Ames Research Center / Bay Area Environmental Research Institute, CA, USAUNSPECIFIED
Krause, J.ESA, European Space Research and Technology Centre (ESTEC), Noordwijk, NetherlandsUNSPECIFIED
Demets, R.ESA, European Space Research and Technology Centre (ESTEC), Noordwijk, NetherlandsUNSPECIFIED
Caplin, N.ESA, European Space Research and Technology Centre (ESTEC), Noordwijk, NetherlandsUNSPECIFIED
Koehler, A.ESA, European Space Research and Technology Centre (ESTEC), Noordwijk, NetherlandsUNSPECIFIED
Tortora, A.Kayser Italia Srl, Livorno, ItalyUNSPECIFIED
Hemmersbach, R.Gravitational Biology Department, Institute of Aerospace Medicine, German Aerospace Center (dlr), Cologne, Germany; Ruth.Hemmersbach (at) dlr.dehttps://orcid.org/0000-0001-5308-6715
Hellweg, C.E.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Christine.Hellweg (at) dlr.dehttps://orcid.org/0000-0002-2223-3580
Moeller, R.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (dlr), Cologne, Germany; ralf.moeller (at) dlr.dehttps://orcid.org/0000-0002-2371-0676
Date:20 November 2019
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:Biofilms
Event Title:ASGSR 2019
Event Location:Denver, Colorado, USA
Event Type:international Conference
Event Dates:20.-23-Nov. 2019
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Institute of Aerospace Medicine > Gravitational Biology
Deposited By: Kopp, Kerstin
Deposited On:18 Dec 2019 09:18
Last Modified:18 Dec 2019 09:18

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