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Impact of Single Dose Photons and Carbon Ions on Perfusion and Vascular Permeability: A Dynamic Contrast-Enhanced MRI Pilot Study in the Anaplastic Rat Prostate Tumor R3327-AT1

Bendinger, Alina L. and Seyler, Lisa and Saager, Maria and Debus, Charlotte and Peschke, Peter and Komljenovic, Dorde and Debus, Jürgen and Peter, Jörg and Floca, Ralf O. and Karger, Christian P. and Glowa, Christin (2019) Impact of Single Dose Photons and Carbon Ions on Perfusion and Vascular Permeability: A Dynamic Contrast-Enhanced MRI Pilot Study in the Anaplastic Rat Prostate Tumor R3327-AT1. Radiation Research. Radiation Research Society. DOI: 10.1667/RR15459.1 ISSN 0033-7587 (In Press)

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Abstract

We collected initial quantitative information on the effects of high-dose carbon (12C) ions compared to photons on vascular damage in anaplastic rat prostate tumors, with the goal of elucidating differences in response to high-LET radiation, using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Syngeneic R3327-AT1 rat prostate tumors received a single dose of either 16 or 37 Gy 12C ions or 37 or 85 Gy 6 MV photons (iso-absorbed and iso-effective doses, respectively). The animals underwent DCE-MRI prior to, and on days 3, 7, 14 and 21 postirradiation. The extended Tofts model was used for pharmacokinetic analysis. At day 21, tumors were dissected and histologically examined. The results of this work showed the following: 1. 12C ions led to stronger vascular changes compared to photons, independent of dose; 2. Tumor growth was comparable for all radiation doses and modalities until day 21; 3. Nonirradiated, rapidly growing control tumors showed a decrease in all pharmacokinetic parameters (area under the curve, Ktrans, ve, vp) over time; 4. 12C-ion-irradiated tumors showed an earlier increase in area under the curve and Ktrans than photon-irradiated tumors; 5. 12C-ion irradiation resulted in more homogeneous parameter maps and histology compared to photons; and 6. 12C-ion irradiation led to an increased microvascular density and decreased proliferation activity in a largely dose-independent manner compared to photons. Postirradiation changes related to 12C ions and photons were detected using DCE-MRI, and correlated with histological parameters in an anaplastic experimental prostate tumor. In summary, this pilot study demonstrated that exposure to 12C ions increased the perfusion and/or permeability faster and led to larger changes in DCE-MRI parameters resulting in increased vessel density and presumably less hypoxia at the end of the observation period when compared to photons. Within this study no differences were found between curative and sub-curative doses in either modality.

Item URL in elib:https://elib.dlr.de/131007/
Document Type:Article
Title:Impact of Single Dose Photons and Carbon Ions on Perfusion and Vascular Permeability: A Dynamic Contrast-Enhanced MRI Pilot Study in the Anaplastic Rat Prostate Tumor R3327-AT1
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Bendinger, Alina L.Medical Physics in Radiology, German Cancer Research Center (DKFZ)UNSPECIFIED
Seyler, LisaInstitute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)UNSPECIFIED
Saager, MariaMedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ)UNSPECIFIED
Debus, Charlottecharlotte.debus (at) dlr.dehttps://orcid.org/0000-0002-7156-2022
Peschke, PeterMedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ)UNSPECIFIED
Komljenovic, DordeMedical Physics in Radiology, German Cancer Research Center (DKFZ)UNSPECIFIED
Debus, JürgenDepartment of Radiation Oncology and Radiotherapy, University Hospital HeidelbergUNSPECIFIED
Peter, JörgMedical Physics in Radiology, German Cancer Research Center (DKFZ)UNSPECIFIED
Floca, Ralf O.Medical Image Computing, German Cancer Research Center (DKFZ)UNSPECIFIED
Karger, Christian P.Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ)UNSPECIFIED
Glowa, ChristinMedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ)UNSPECIFIED
Date:November 2019
Journal or Publication Title:Radiation Research
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI :10.1667/RR15459.1
Publisher:Radiation Research Society
ISSN:0033-7587
Status:In Press
Keywords:Strahlentherapie, Prostata-Tumoren, Magnetresonanz-Tomographie
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Space Technology
DLR - Research area:Raumfahrt
DLR - Program:R SY - Technik für Raumfahrtsysteme
DLR - Research theme (Project):R - Vorhaben SISTEC
Location: Köln-Porz
Institutes and Institutions:Institut of Simulation and Software Technology
Institut of Simulation and Software Technology > High Performance Computing
Deposited By: Debus, Charlotte
Deposited On:13 Dec 2019 12:52
Last Modified:13 Dec 2019 12:52

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