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Impact of acute sleep deprivation on dynamic functional connectivity states

Li, C. and Fronczek, J. and Lange, D. and Hennecke, E. and Kroll, T. and Matusch, A. and Aeschbach, D. and Bauer, A. and Elmenhorst, E.-M. and Elmenhorst, D. (2019) Impact of acute sleep deprivation on dynamic functional connectivity states. Human Brain Mapping, 41 (4), pp. 994-1005. Wiley. DOI: 10.1002/hbm.24855 ISSN 1065-9471

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Official URL: https://onlinelibrary.wiley.com/doi/10.1002/hbm.24855

Abstract

Sleep deprivation (SD) could amplify the temporal fluctuation of spontaneous brain activities that reflect different arousal levels using a dynamic functional connectivity (dFC) approach. Therefore, we intended to evaluate the test–retest reliability of dFC characteristics during rested wakefulness (RW), and to explore how the properties of these dynamic connectivity states were affected by extended durations of acute sleep loss (28/52 hr). We acquired resting-state fMRI and neuropsychological datasets in two independent studies: (a) twice during RW and once after 28 hr of SD (n = 15) and (b) after 52 hr of SD and after 14 hr of recovery sleep (RS; n = 14). Sliding-window correlations approach was applied to estimate their covariance matrices and corresponding three connectivity states were generated. The test–retest reliability of dFC properties demonstrated mean dwell time and fraction of connectivity states were reliable. After SD, the mean dwell time of a specific state, featured by strong subcortical–cortical anticorrelations, was significantly increased. Conversely, another globally hypoconnected state was significantly decreased. Subjective sleepiness and objective performances were separately positive and negative correlated with the increased and decreased state. Two brain connectivity states and their alterations might be sufficiently sensitive to reflect changes in the dynamics of brain mental activities after sleep loss.

Item URL in elib:https://elib.dlr.de/130434/
Document Type:Article
Title:Impact of acute sleep deprivation on dynamic functional connectivity states
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Li, C.UNSPECIFIEDUNSPECIFIED
Fronczek, J.UNSPECIFIEDUNSPECIFIED
Lange, D.denise.lange (at) dlr.deUNSPECIFIED
Hennecke, E.UNSPECIFIEDUNSPECIFIED
Kroll, T.UNSPECIFIEDUNSPECIFIED
Matusch, A.UNSPECIFIEDUNSPECIFIED
Aeschbach, D.daniel.aeschbach (at) dlrUNSPECIFIED
Bauer, A.UNSPECIFIEDUNSPECIFIED
Elmenhorst, E.-M.Eva-Maria.Elmenhorst (at) dlr.dehttps://orcid.org/0000-0003-0336-6705
Elmenhorst, D.UNSPECIFIEDUNSPECIFIED
Date:2019
Journal or Publication Title:Human Brain Mapping
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:41
DOI :10.1002/hbm.24855
Page Range:pp. 994-1005
Publisher:Wiley
ISSN:1065-9471
Status:Published
Keywords:acute sleep deprivation; dynamic connectivity states; light sleep/drowsiness; resting-state fMRI; test–retest reliability
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Aeronautics
HGF - Program Themes:air traffic management and operations
DLR - Research area:Aeronautics
DLR - Program:L AO - Air Traffic Management and Operation
DLR - Research theme (Project):L - Human factors and safety in Aeronautics, R - Somnosafe
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Sleep and Human Factors Research
Deposited By: Sender, Alina
Deposited On:20 Nov 2019 13:06
Last Modified:30 Sep 2020 14:41

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