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Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian period in Humans

Chang, A.-M. and Duffy, J.F. and Buxton, O.M. and Lane, J.M. and Aeschbach, D. and Anderson, C. and Bjonnes, A.C. and Cain, S.W. and Cohen, D.A. and Frayling, T.M. and Gooley, J.J. and Jones, S.E. and Klerman, E.B. and Lockley, S.W. and Munch, M. and Rajaratnam, S.M.W. and Rueger, M. and Rutter, M.K. and Santhi, N. and Schauermaier, K. and Van Reen, E. and Weedon, M.N. and Czeisler, C.A. and Scheer, F.A.J.L. and Saxena, R. (2019) Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian period in Humans. Scientific Reports, 9 (1), p. 5350. Nature Publishing Group. doi: 10.1038/s41598-019-41712-1. ISSN 2045-2322.

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Official URL: https://www.nature.com/articles/s41598-019-41712-1

Abstract

the PERIOD2 (PER2) gene is a core molecular component of the circadian clock and plays an important role in the generation and maintenance of daily rhythms. Rs35333999, a missense variant of PER2 common in European populations, has been shown to associate with later chronotype. Chronotype relates to the timing of biological and behavioral activities, including when we sleep, eat, and exercise, and later chronotype is associated with longer intrinsic circadian period (cycle length), a fundamental property of the circadian system. Thus, we tested whether this PER2 variant was associated with circadian period and found significant associations with longer intrinsic circadian period as measured under forced desynchrony protocols, the ‘gold standard’ for intrinsic circadian period assessment. Minor allele (T) carriers exhibited significantly longer circadian periods when determinations were based on either core body temperature or plasma melatonin measurements, as compared to non-carriers (by 12 and 11 min, respectively; accounting for ~7% of inter-individual variance). These findings provide a possible underlying biological mechanism for inter-individual differences in chronotype, and support the central role of PER2 in the human circadian timing system.

Item URL in elib:https://elib.dlr.de/130416/
Document Type:Article
Title:Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian period in Humans
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Chang, A.-M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duffy, J.F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buxton, O.M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lane, J.M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aeschbach, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anderson, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bjonnes, A.C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cain, S.W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cohen, D.A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frayling, T.M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gooley, J.J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jones, S.E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klerman, E.B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lockley, S.W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munch, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rajaratnam, S.M.W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rueger, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rutter, M.K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Santhi, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schauermaier, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Reen, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weedon, M.N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Czeisler, C.A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheer, F.A.J.L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saxena, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date:2019
Journal or Publication Title:Scientific Reports
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:9
DOI:10.1038/s41598-019-41712-1
Page Range:p. 5350
Publisher:Nature Publishing Group
ISSN:2045-2322
Status:Published
Keywords:Circadian period, Chronotype, PER2 genetic variant, Individual trait
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Aeronautics
HGF - Program Themes:air traffic management and operations
DLR - Research area:Aeronautics
DLR - Program:L AO - Air Traffic Management and Operation
DLR - Research theme (Project):L - Human factors and safety in Aeronautics (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Sleep and Human Factors Research
Deposited By: Sender, Alina
Deposited On:20 Nov 2019 12:46
Last Modified:30 Sep 2020 13:09

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