Genotoxic and Cytotoxic Responses of Recombinant Salmonella typhimurium TA1535 Induced by Simulated Space Radiation Qualities

Baumstark-Khan, C. and Moeller, R. and Testard, I. and Saintigny, Y. and Hellweg, C.E. (2019) Genotoxic and Cytotoxic Responses of Recombinant Salmonella typhimurium TA1535 Induced by Simulated Space Radiation Qualities. AbSciCon 2019, 2019-06-24 - 2019-06-28, Bellevue, Washington.

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Abstract

Introduction: For risk assessment, the mutagenic potential of the heavy ion component of the galactic cosmic radiation is of major concern for tumor induction as radiation late effects. The genetically modified TA1535 Salmonella typhimurium strain (SWITCH) reports on the presence of genotoxic conditions by dose dependent increase of bioluminescence induction and on the presence of cytotoxic conditions by dose dependent decrease in GFP fluorescence. By this, it is possible to analyze bacterial inactivation and mutation induction by ionizing radiation in parallel in the same cell within short time.

Item URL in elib:

https://elib.dlr.de/130290/

Document Type:

Conference or Workshop Item (Speech)

Title:

Genotoxic and Cytotoxic Responses of Recombinant Salmonella typhimurium TA1535 Induced by Simulated Space Radiation Qualities

Authors:

Authors	Institution or Email of Authors	Author's ORCID iD	ORCID Put Code
Baumstark-Khan, C.	Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Christa.Baumstark-Khan (at) dlr.de	https://orcid.org/0000-0002-9329-0128	UNSPECIFIED
Moeller, R.	Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; ralf.moeller (at) dlr.de	https://orcid.org/0000-0002-2371-0676	UNSPECIFIED
Testard, I.	CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France; isabelle.testard (at) cea.fr	UNSPECIFIED	UNSPECIFIED
Saintigny, Y.	LARIA, GANIL, Bd Henri Becquerel, 14076 Caen, France; saintigny (at) ganil.fr.	UNSPECIFIED	UNSPECIFIED
Hellweg, C.E.	Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Christine.Hellweg (at) dlr.de	https://orcid.org/0000-0002-2223-3580	UNSPECIFIED

Date:

24 June 2019

Refereed publication:

Yes

Open Access:

Yes

Gold Open Access:

In SCOPUS:

In ISI Web of Science:

Status:

Published

Keywords:

space radiation, TA1535 Salmonella typhimurium, genotoxic and cytotoxic responses

Event Title:

AbSciCon 2019

Event Location:

Bellevue, Washington

Event Type:

international Conference

Event Start Date:

24 June 2019

Event End Date:

28 June 2019

HGF - Research field:

Aeronautics, Space and Transport

HGF - Program:

Space

HGF - Program Themes:

Research under Space Conditions

DLR - Research area:

Raumfahrt

DLR - Program:

R FR - Research under Space Conditions

DLR - Research theme (Project):

R - Vorhaben Strahlenbiologie (old)

Location:

Köln-Porz

Institutes and Institutions:

Institute of Aerospace Medicine > Radiation Biology

Deposited By:

Kopp, Kerstin

Deposited On:

21 Nov 2019 15:51

Last Modified:

24 Apr 2024 20:33

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