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Microbial biofilms in space – Evaluating copper-based antimicrobial surfaces in the upcoming ESA space experiment BIOFILMS

Siems, K. and Müller, D. and Mücklich, F. and Grohmann, E. and Mancinelli, R.L. and Krause, J. and Demets, R. and Caplin, N. and Koehler, A. and Tortora, A. and Hemmersbach, R. and Hellweg, C.E. and Moeller, R. (2019) Microbial biofilms in space – Evaluating copper-based antimicrobial surfaces in the upcoming ESA space experiment BIOFILMS. 12th Student Symposium on Molecular Medicine, May 4, 2019, Ulm University.

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Abstract

An enduring human presence in space is required to achieve many goals of ESA´s and NASA´s space programs. During long-term missions, astronauts are exposed to various conditions such as microgravity, radiation, sleep-disruption, insufficient nutrition and also microbial contamination. Since astronauts´ immune function is compromised, all these factors increase the health risk for the crew. Therefore, improved spaceflight-suitable methods for microbiological monitoring, hygiene and decontamination are important. Microbial biofilms are of particular concern in spaceflight, because they cannot only cause damage to equipment but also be a risk for human health. Certain metals have antimicrobial properties such as copper and its respective alloys and therefore, prevent the formation of biofilms. However, precise evaluation of suitable antimicrobial materials for space flight is essential. Within the ESA project BIOFILMS (“Biofilm Inhibition on Flight equipment and on board the ISS using microbiologically Lethal Metal Surfaces"), effects of microgravity on biofilm formation on tailor-made nanostructured metallic surfaces are going to be examined. For that, human-associated microorganisms and antimicrobial surfaces with different chemical compositions and geometric nanostructures are selected. Experiments will be conducted aboard the ISS, where microbial growth will occur under optimal biofilm inducing conditions inside a particular designed hardware. The selected antimicrobial surfaces are supposed to be tested under different spaceflight-relevant gravitational regimes. Here, preliminary experiments with Staphylococcus capitis subsp. capitis for the BIOFILMS project will be presented. S. capitis forms biofilms and is related to infections such as endocarditis, urinary tract infections and catheter induced bacteremia. The reduction of growth and biofilm formation under the influence of copper-based, nanostructured surfaces was investigated.

Item URL in elib:https://elib.dlr.de/130285/
Document Type:Conference or Workshop Item (Speech)
Title:Microbial biofilms in space – Evaluating copper-based antimicrobial surfaces in the upcoming ESA space experiment BIOFILMS
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Siems, K.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; katharina.siems (at) dlr.deUNSPECIFIED
Müller, D.Department of Materials Science and Engineering, Saarland University, Saarbrücken, GermanyUNSPECIFIED
Mücklich, F.Department of Materials Science and Engineering, Saarland University, Saarbrücken, GermanyUNSPECIFIED
Grohmann, E.Beuth Hochschule für Technik, Fachbereich Life Sciences and Technologie, Berlin, GermanyUNSPECIFIED
Mancinelli, R.L.NASA Ames Research Center / Bay Area Environmental Research Institute, CA, USAUNSPECIFIED
Krause, J.ESA, European Space Research and Technology Centre (ESTEC), Noordwijk, NetherlandsUNSPECIFIED
Demets, R.ESA, European Space Research and Technology Centre (ESTEC), Noordwijk, NetherlandsUNSPECIFIED
Caplin, N.ESA, European Space Research and Technology Centre (ESTEC), Noordwijk, NetherlandsUNSPECIFIED
Koehler, A.ESA, European Space Research and Technology Centre (ESTEC), Noordwijk, NetherlandsUNSPECIFIED
Tortora, A.Kayser Italia Srl, Livorno, ItalyUNSPECIFIED
Hemmersbach, R.Gravitational Biology Department, Institute of Aerospace Medicine, German Aerospace Center (dlr), Cologne, Germany; Ruth.Hemmersbach (at) dlr.dehttps://orcid.org/0000-0001-5308-6715
Hellweg, C.E.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Christine.Hellweg (at) dlr.dehttps://orcid.org/0000-0002-2223-3580
Moeller, R.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (dlr), Cologne, Germany; ralf.moeller (at) dlr.dehttps://orcid.org/0000-0002-2371-0676
Date:4 May 2019
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:Biofilms
Event Title:12th Student Symposium on Molecular Medicine
Event Location:Ulm University
Event Type:international Conference
Event Dates:May 4, 2019
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Institute of Aerospace Medicine > Gravitational Biology
Deposited By: Kopp, Kerstin
Deposited On:21 Nov 2019 15:50
Last Modified:21 Nov 2019 15:50

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