Egoriti, R. and Landreani, F. and Costantini, L. and Mulder, E. and Gerlach, D.A. and Vaida, P. and Migeotte, P.-F. and Caiani, E.G. (2019) Left ventricular volume and mass adaptation after 58-days head-down bed-rest assessed by cine-MRI, and effectiveness of high-intensity jump training countermeasure. In: EUROPEAN HEART JOURNAL, 40. European Society of Cardiology Congress, 25.-29. August 2018, Munich, Germany. doi: 10.1093/eurheartj/ehz747.0195.
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Official URL: https://doi.org/10.1093/eurheartj/ehz747.0195
Abstract
Aims Prolonged immobilization generates cardiac deconditioning, a risk factor for cardiovascular disease, and efficient countermeasures (CM) are needed to prevent it. Our aim was to assess by Cine-MRI the effects of long-term strict head-down (−6 degrees) bed-rest (BR) deconditioning, and the effectiveness of high-intensity jump training CM, on left ventricular (LV) function and mass. Methods 23 male participants (29±6 years, 181±6 cm, 77±7 kg) were enrolled. The experiment was conducted at: envihab (Koln, DLR, Germany) as part of the European Space Agency BR studies. Volunteers were randomly allocated to the jump training group (JUMP, n=12) or the control group (CTRL, n=11). A typical training session consisted of 4x10 countermovement jumps and 2x10 hops in a sledge jump system, with 5–6 sessions per week. Steady-state free precession cine-MRI images were obtained (25 frames/cardiac cycle, 8mm thickness, no gap, no overlap) as stack of short-axis images covering the whole LV from base to apex, before (PRE) and after 58-days (HDT58) of BR. Endocardial and epicardial semi-automated contouring was performed using custom software. Results In CTRL group, at HDT58 a reduction in LV mass (9%), end-diastolic (21%), end-systolic (8%) and stroke volume (23%) were observed, while ejection fraction did not change. In JUMP group, the reduction in LV end-diastolic volume was only by 9%, followed by a decrease in end-systolic (10%) and stroke volume (10%), with a preservation of LV mass. In both groups, ejection fraction did not change.
Item URL in elib: | https://elib.dlr.de/130238/ | |||||||||||||||||||||||||||
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Document Type: | Conference or Workshop Item (Poster) | |||||||||||||||||||||||||||
Title: | Left ventricular volume and mass adaptation after 58-days head-down bed-rest assessed by cine-MRI, and effectiveness of high-intensity jump training countermeasure | |||||||||||||||||||||||||||
Authors: |
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Date: | 21 October 2019 | |||||||||||||||||||||||||||
Journal or Publication Title: | EUROPEAN HEART JOURNAL | |||||||||||||||||||||||||||
Refereed publication: | Yes | |||||||||||||||||||||||||||
Open Access: | Yes | |||||||||||||||||||||||||||
Gold Open Access: | No | |||||||||||||||||||||||||||
In SCOPUS: | No | |||||||||||||||||||||||||||
In ISI Web of Science: | Yes | |||||||||||||||||||||||||||
Volume: | 40 | |||||||||||||||||||||||||||
DOI : | 10.1093/eurheartj/ehz747.0195 | |||||||||||||||||||||||||||
Status: | Published | |||||||||||||||||||||||||||
Keywords: | Cardiac Magnetic Resonance; Dimensions; Volumes and Mass | |||||||||||||||||||||||||||
Event Title: | European Society of Cardiology Congress | |||||||||||||||||||||||||||
Event Location: | Munich, Germany | |||||||||||||||||||||||||||
Event Type: | international Conference | |||||||||||||||||||||||||||
Event Dates: | 25.-29. August 2018 | |||||||||||||||||||||||||||
HGF - Research field: | Aeronautics, Space and Transport | |||||||||||||||||||||||||||
HGF - Program: | Space | |||||||||||||||||||||||||||
HGF - Program Themes: | Research under Space Conditions | |||||||||||||||||||||||||||
DLR - Research area: | Raumfahrt | |||||||||||||||||||||||||||
DLR - Program: | R FR - Research under Space Conditions | |||||||||||||||||||||||||||
DLR - Research theme (Project): | R - Vorhaben Systemphysiologie (old) | |||||||||||||||||||||||||||
Location: | Köln-Porz | |||||||||||||||||||||||||||
Institutes and Institutions: | Institute of Aerospace Medicine Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace Institute of Aerospace Medicine > Leitungsbereich ME | |||||||||||||||||||||||||||
Deposited By: | Schrage, Larissa | |||||||||||||||||||||||||||
Deposited On: | 11 Jan 2021 14:47 | |||||||||||||||||||||||||||
Last Modified: | 11 Jan 2021 14:47 |
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