elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Left ventricular volume and mass adaptation after 58-days head-down bed-rest assessed by cine-MRI, and effectiveness of high-intensity jump training countermeasure

Egoriti, R. and Landreani, F. and Costantini, L. and Mulder, E. and Gerlach, D.A. and Vaida, P. and Migeotte, P.-F. and Caiani, E.G. (2019) Left ventricular volume and mass adaptation after 58-days head-down bed-rest assessed by cine-MRI, and effectiveness of high-intensity jump training countermeasure. In: EUROPEAN HEART JOURNAL, 40. European Society of Cardiology Congress, 25.-29. August 2018, Munich, Germany. doi: 10.1093/eurheartj/ehz747.0195.

[img] PDF
85kB

Official URL: https://doi.org/10.1093/eurheartj/ehz747.0195

Abstract

Aims Prolonged immobilization generates cardiac deconditioning, a risk factor for cardiovascular disease, and efficient countermeasures (CM) are needed to prevent it. Our aim was to assess by Cine-MRI the effects of long-term strict head-down (−6 degrees) bed-rest (BR) deconditioning, and the effectiveness of high-intensity jump training CM, on left ventricular (LV) function and mass. Methods 23 male participants (29±6 years, 181±6 cm, 77±7 kg) were enrolled. The experiment was conducted at: envihab (Koln, DLR, Germany) as part of the European Space Agency BR studies. Volunteers were randomly allocated to the jump training group (JUMP, n=12) or the control group (CTRL, n=11). A typical training session consisted of 4x10 countermovement jumps and 2x10 hops in a sledge jump system, with 5–6 sessions per week. Steady-state free precession cine-MRI images were obtained (25 frames/cardiac cycle, 8mm thickness, no gap, no overlap) as stack of short-axis images covering the whole LV from base to apex, before (PRE) and after 58-days (HDT58) of BR. Endocardial and epicardial semi-automated contouring was performed using custom software. Results In CTRL group, at HDT58 a reduction in LV mass (9%), end-diastolic (21%), end-systolic (8%) and stroke volume (23%) were observed, while ejection fraction did not change. In JUMP group, the reduction in LV end-diastolic volume was only by 9%, followed by a decrease in end-systolic (10%) and stroke volume (10%), with a preservation of LV mass. In both groups, ejection fraction did not change.

Item URL in elib:https://elib.dlr.de/130238/
Document Type:Conference or Workshop Item (Poster)
Title:Left ventricular volume and mass adaptation after 58-days head-down bed-rest assessed by cine-MRI, and effectiveness of high-intensity jump training countermeasure
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Egoriti, R.Politecnico di Milano, Milan, ItalyUNSPECIFIED
Landreani, F.Politecnico di Milano, Biomed. Eng. Dpt.UNSPECIFIED
Costantini, L.Azienda Sanitaria Locale Lecce - P.O. Santa Caterina Novella, U.O. di Cardiologia e UTIC, Lecce, ItalyUNSPECIFIED
Mulder, E.German Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, GermanyUNSPECIFIED
Gerlach, D.A.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germanyhttps://orcid.org/0000-0001-7044-6065
Vaida, P.Université Bordeaux Segalen, FranceUNSPECIFIED
Migeotte, P.-F.Université libre de Bruxelles (ULB), Brussels, BelgiumUNSPECIFIED
Caiani, E.G.Politecnico di Milano, Biomed. Eng. Dpt.UNSPECIFIED
Date:21 October 2019
Journal or Publication Title:EUROPEAN HEART JOURNAL
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:Yes
Volume:40
DOI :10.1093/eurheartj/ehz747.0195
Status:Published
Keywords:Cardiac Magnetic Resonance; Dimensions; Volumes and Mass
Event Title:European Society of Cardiology Congress
Event Location:Munich, Germany
Event Type:international Conference
Event Dates:25.-29. August 2018
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:11 Jan 2021 14:47
Last Modified:11 Jan 2021 14:47

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Copyright © 2008-2017 German Aerospace Center (DLR). All rights reserved.