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P586Left ventricular volume and mass adaptation after 58-days head-down bed-rest assessed by cine-MRI, and effectiveness of high-intensity jump training countermeasure

Egoriti, R. and Landreani, F. and Costantini, L. and Mulder, E. and Gerlach, D.A. and Vaida, P. and Migeotte, P-F. and Caiani, E.G. (2019) P586Left ventricular volume and mass adaptation after 58-days head-down bed-rest assessed by cine-MRI, and effectiveness of high-intensity jump training countermeasure. European Heart Journal. Oxford University Press. DOI: 10.1093/eurheartj/ehz747.0195 ISSN 0195-668X

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Abstract

Aims: Prolonged immobilization generates cardiac deconditioning, a risk factor for cardiovascular disease, and efficient countermeasures (CM) are needed to prevent it. Our aim was to assess by Cine-MRI the effects of long-term strict head-down (−6 degrees) bed-rest (BR) deconditioning, and the effectiveness of high-intensity jump training CM, on left ventricular (LV) function and mass. Methods: 23 male participants (29±6 years, 181±6 cm, 77±7 kg) were enrolled. The experiment was conducted at: envihab (Koln, DLR, Germany) as part of the European Space Agency BR studies. Volunteers were randomly allocated to the jump training group (JUMP, n=12) or the control group (CTRL, n=11). A typical training session consisted of 4x10 countermovement jumps and 2x10 hops in a sledge jump system, with 5–6 sessions per week. Steady-state free precession cine-MRI images were obtained (25 frames/cardiac cycle, 8mm thickness, no gap, no overlap) as stack of shortaxis images covering the whole LV from base to apex, before (PRE) and after 58-days (HDT58) of BR. Endocardial and epicardial semi-automated contouring was performed using custom software. Results: In CTRL group, at HDT58 a reduction in LV mass (9%), enddiastolic (21%), end-systolic (8%) and stroke volume (23%) were observed, while ejection fraction did not change. In JUMP group, the reduction in LV end-diastolic volume was only by 9%, followed by a decrease in endsystolic (10%) and stroke volume (10%), with a preservation of LV mass. In both groups, ejection fraction did not change. Conclusions: Cardiac adaptation to deconditioning due to immobilization induced by BR resulted in a reduction of cardiac volumes and function, together with a decrease in LV mass. Interestingly, the applied JUMP countermeasure appeared able to partially reverse these effects, in particular by reducing the decrease in end-diastolic volume and preserving LV mass. This information could be useful for better understanding physiologic changes in patients undergoing long periods of immobilization, as well as to apply the studied countermeasure during space flight to reduce cardiac deconditioning.

Item URL in elib:https://elib.dlr.de/130238/
Document Type:Article
Title:P586Left ventricular volume and mass adaptation after 58-days head-down bed-rest assessed by cine-MRI, and effectiveness of high-intensity jump training countermeasure
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Egoriti, R.UNSPECIFIEDUNSPECIFIED
Landreani, F.Politecnico di Milano, Biomed. Eng. Dpt.UNSPECIFIED
Costantini, L.Citta Di Lecce Hospital, GVM Care& Research, Lecce, ItalyUNSPECIFIED
Mulder, E.German Aerospace Center, Institute of Aerospace MedicineUNSPECIFIED
Gerlach, D.A.German Aerospace Center (DLR)https://orcid.org/0000-0001-7044-6065
Vaida, P.University of BordeauxUNSPECIFIED
Migeotte, P-F.UNSPECIFIEDUNSPECIFIED
Caiani, E.G.Politecnico di Milano, Biomed. Eng. Dpt.UNSPECIFIED
Date:2019
Journal or Publication Title:European Heart Journal
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI :10.1093/eurheartj/ehz747.0195
Publisher:Oxford University Press
ISSN:0195-668X
Status:Published
Keywords:Left ventricular volume; mass Adaptation; head-down bed-rest; cine-MRI, and effectiveness of high-intensity jump training countermeasure
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Deposited By: Schrage, Larissa
Deposited On:07 Nov 2019 13:21
Last Modified:20 Jan 2020 13:06

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