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cGMP manipulation in cardiometabolic disease: chances and challenges

Jordan, J. and Hildebrand, S. and Pfeiffer, A. (2019) cGMP manipulation in cardiometabolic disease: chances and challenges. Current Opinion in Cardiology, 34 (4), pp. 376-383. Lippincott Williams & Wilkins Ltd.. doi: 10.1097/HCO.0000000000000630. ISSN 0268-4705.

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Official URL: https://journals.lww.com/co-cardiology/Abstract/2019/07000/cGMP_manipulation_in_cardiometabolic_disease_.11.aspx


Purpose of review Cardiovascular and metabolic diseases are closely linked and commonly occur in the same patients. This review focuses on the cyclic guanosine monophosphate (cGMP) system and its crosstalk between metabolism and the cardiovascular system. Recent findings Recent studies suggest that cGMP, which serves as second messenger for nitric oxide and for natriuretic peptides, improves oxidative metabolism and insulin signaling. The clinical evidence is particularly strong for the natriuretic peptide branch of the cGMP system. Clinical trials suggested improvements in insulin sensitivity and reductions in the risk of progressing to type 2 diabetes mellitus. However, further studies are needed. Summary Enhancing cGMP signaling through nonpharmacological or pharmacological means may improve glucose metabolism in addition to affecting the cardiovascular system. However, excessive cGMP production could have significant unwanted cardiovascular and metabolic effects.

Item URL in elib:https://elib.dlr.de/129854/
Document Type:Article
Title:cGMP manipulation in cardiometabolic disease: chances and challenges
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Hildebrand, S.Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, Bonn, Germany.UNSPECIFIED
Pfeiffer, A.Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, Bonn, Germany.UNSPECIFIED
Date:July 2019
Journal or Publication Title:Current Opinion in Cardiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
DOI :10.1097/HCO.0000000000000630
Page Range:pp. 376-383
Publisher:Lippincott Williams & Wilkins Ltd.
Keywords:cyclic guanosine monophosphate, hypertension, insulin resistance, natriuretic peptides, nitric oxide
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:29 Oct 2019 14:25
Last Modified:30 Sep 2020 13:58

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