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Influences on hypoxia exercise on whole body insulin sensitivity and oxidative metabolism in older individuals

Chobanyan-Jürgens, C. and Scheibe, R.J. and Potthast, A.B. and Hein, M. and Smith, A. and Freund, R. and Tegtbur, U. and Das, A.M. and Engeli, S. and Jordan, J. and Haufe, S. (2019) Influences on hypoxia exercise on whole body insulin sensitivity and oxidative metabolism in older individuals. Journal of Clinical Endocrinology and Metabolism, 104 (11), pp. 5238-5248. The Endocrine Society. DOI: 10.1210/jc.2019-00411 ISSN 0021-972X

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Official URL: https://academic.oup.com/jcem

Abstract

Context Aging is a primary risk factor for most chronic diseases, including type 2 diabetes. Both exercise and hypoxia regulate pathways that ameliorate age-associated metabolic muscle dysfunction. Objective We hypothesized that the combination of hypoxia and exercise would be more effective in improving glucose metabolism than normoxia exercise. Design and Participants We randomized 29 older sedentary individuals (62 ± 6 years; 14 women, 15 men) to bicycle exercise under normobaric hypoxia (fraction of inspired oxygen = 15%) or normoxia (fraction of inspired oxygen = 21%). Intervention Participants trained thrice weekly for 30 to 40 minutes over 8 weeks at a heart rate corresponding to 60% to 70% of peak oxygen update. Main Outcome Measures Insulin sensitivity measured by hyperinsulinemic-euglycemic glucose clamp and muscle protein expression before and after hyperinsulinemic-euglycemic glucose clamp. Results Heart rate and perceived exertion during training were similar between groups, with lower oxygen saturation when exercising under hypoxia (88.7 ± 1.5 vs 96.2 ± 1.2%, P < 0.01). Glucose infusion rate after 8 weeks increased in both the hypoxia (5.7 ± 1.1 to 6.7 ± 1.3 mg/min/kg; P < 0.01) and the normoxia group (6.2 ± 2.1 to 6.8 ± 2.1 mg/min/kg; P = 0.04), with a mean difference between groups of –0.44 mg/min/kg; 95% CI, –1.22 to 0.34; (P = 0.25). Markers of mitochondrial content and oxidative capacity in skeletal muscle were similar after training in both groups. Changes in Akt phosphorylation and glucose transporter 4 under fasting and insulin-stimulated conditions were not different between groups over time. Conclusions Eight weeks of hypoxia endurance training led to similar changes in insulin sensitivity and markers of oxidative metabolism compared with normoxia training. Normobaric hypoxia exercise did not enhance metabolic effects in sedentary older women and men beyond exercise alone.

Item URL in elib:https://elib.dlr.de/129781/
Document Type:Article
Title:Influences on hypoxia exercise on whole body insulin sensitivity and oxidative metabolism in older individuals
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Chobanyan-Jürgens, C.Institute of Clinical Pharmacology, Hannover Medical School, 30625 Hannover, GermanyUNSPECIFIED
Scheibe, R.J.Institute of Cell Biochemistry, Hannover Medical School, 30625 Hannover, GermanyUNSPECIFIED
Potthast, A.B.Department of Pediatrics, Pediatric Metabolic Medicine, Hannover Medical School, 30625 Hannover,UNSPECIFIED
Hein, M.Institute of Sports Medicine, Hannover Medical School, 30625 Hannover, GermanyUNSPECIFIED
Smith, A.Institute of Biometry, Hannover Medical School, 30625 Hannover, GermanyUNSPECIFIED
Freund, R.Institute of Cell Biochemistry, Hannover Medical School, 30625 Hannover, GermanyUNSPECIFIED
Tegtbur, U.Institute of Sports Medicine, Hannover Medical School, 30625 Hannover, GermanyUNSPECIFIED
Das, A.M.Department of Pediatrics, Pediatric Metabolic Medicine, Hannover Medical School, 30625 Hannover,GermanyUNSPECIFIED
Engeli, S.Institute of Clinical Pharmacology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Haufe, S.Institute of Clinical Pharmacology, Hannover Medical School, 30625 Hannover, GermanyUNSPECIFIED
Date:2019
Journal or Publication Title:Journal of Clinical Endocrinology and Metabolism
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:104
DOI :10.1210/jc.2019-00411
Page Range:pp. 5238-5248
Publisher:The Endocrine Society
ISSN:0021-972X
Status:Published
Keywords:Hypoxia Exercise; Whole-Body; Insulin; Sensitivity; Oxidative; Metabolism; Individuals
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:29 Oct 2019 13:40
Last Modified:29 Oct 2019 13:40

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