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An oscillometric approach in assessing early vascular ageing biomarkers following long-term space flights

Hoffmann, F. and Möstl, S. and Luchitskaya, E. and Funtova, I.I. and Jordan, J. and Baevsky, R. and Tank, J. (2019) An oscillometric approach in assessing early vascular ageing biomarkers following long-term space flights. International Journal of Cardiology Hypertension. Elsevier. DOI: 10.1016/j.ijchy.2019.100013 ISSN 2590-0862

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Official URL: http://www.journals.elsevier.com/international-journal-of-cardiology-hypertension/

Abstract

Purpose: The environmental conditions in space, particularly exposure to cosmic radiation, coupled with decreased mobility, altered glucose metabolism, and hemodynamic changes may promote cardiovascular disease Therefore, we assessed early vascular aging markers and hemodynamics using a novel oscillometric blood pressure device. Methodology: In eight cosmonauts (46.5 ± 5.3 yrs, 77.6 ± 8.2 kg, 176 ± 6.2 cm, 7 men/1woman), we determined heart rate, peripheral blood pressure, central blood pressure, and pulse wave velocity in the supine position using an oscillometric brachial device coupled with transfer function analysis. We obtained measurements at baseline (65–90 days before flight) and four days (R+4) and eight days (R+8) after return from six months mission onboard the International Space Station. Results: Compared to baseline, heart rate increased significantly on R+4 (58.6 ± 6.4 vs. 70.3 ± 5.2 bpm) but did not differ on R+8. Central systolic blood pressure increased from 112.5 ± 13.5 on baseline to 125.6 ± 18.5 on Rþ4 and 121.6 ± 9.5 mmHg, albeit showing no statistical significance compared to baseline (p = 0.243/0.295). Peripheral diastolic and systolic as well as central diastolic blood pressure measurements followed this trend. Pulse wave velocity increased non-significantly from baseline (6.7 ± 0.8 m/s) to R+4 (7.2 ± 0.8 m/s, p = 0.499) and stayed elevated on R+8 (7.1 ± 0.5 m/s, p = 0.614). Conclusion: The important finding of our study is that six months in a near-earth orbit do not lead to clinically significant changes in early vascular ageing biomarkers. However, these findings cannot be extrapolated to the conditions encountered in deep space. Non-invasive testing of vascular biomarkers may have utility in detecting vascular risks during space travel at an early stage.

Item URL in elib:https://elib.dlr.de/129732/
Document Type:Article
Title:An oscillometric approach in assessing early vascular ageing biomarkers following long-term space flights
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Hoffmann, F.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Möstl, S.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Luchitskaya, E.Federal State Budgetary Research Institution, State Scientific Center of the Russian Federation, Institute of Biomedical Problems, Russian Academy of Sciences,UNSPECIFIED
Funtova, I.I.Federal State Budgetary Research Institution, State Scientific Center of the Russian Federation, Institute of Biomedical Problems, Russian Academy of Sciences,UNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Baevsky, R.Federal State Budgetary Research Institution, State Scientific Center of the Russian Federation, Institute of Biomedical Problems, Russian Academy of Sciences,UNSPECIFIED
Tank, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Date:August 2019
Journal or Publication Title:International Journal of Cardiology Hypertension
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:No
DOI :10.1016/j.ijchy.2019.100013
Publisher:Elsevier
ISSN:2590-0862
Status:Published
Keywords:Central blood pressure, Pulse wave velocity, Spaceflight Arterial stiffening, Cardiovascular risk, Microgravity, Long term
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:29 Oct 2019 12:58
Last Modified:13 Dec 2019 04:07

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