elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans

Heusser, K. and Tank, J. and Holz, O. and May, M. and Brinkmann, J. and Engeli, S. and Diedrich, A. and Framke, T. and Koch, A. and Großhennig, A. and Danser, A.H.J. and Sweep, F.C.G.J. and Schindler, C. and Schwarz, K. and Krug, N. and Jordan, J. and Hohlfeld, J. M. (2019) Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans. Scientific Reports, 9 (1), p. 3641. Nature Publishing Group. DOI: 10.1038/s41598-019-40343-w ISSN 2045-2322

[img] PDF - Published version
1MB

Official URL: http://www.nature.com/scientificreports

Abstract

Cardiovascular risk rapidly increased following exposure to air pollution. Changes in human autonomic regulation have been implicated based on epidemiological associations between exposure estimates and indirect autonomic nervous system measurements. We conducted a mechanistic study to test the hypothesis that, in healthy older individuals, well-defined experimental exposure to ultrafine carbon particles (UFP) increases sympathetic nervous system activity and more so with added ozone (O3). Eighteen participants (age >50 years, 6 women) were exposed to filtered air (Air), UFP, and UFP + O3 combination for 3 hours during intermittent bicycle ergometer training in a randomized, crossover, double-blind fashion. Two hours following exposure, respiration, electrocardiogram, blood pressure, and muscle sympathetic nerve activity (MSNA) were recorded at supine rest, during deep breathing, and during a Valsalva manoeuvre. Catechols and inflammatory marker levels were measured in venous blood samples. Induced sputum was obtained 3.5 h after exposure. Combined exposure to UFP + O3 but not UFP alone, caused a significant increase in sputum neutrophils and circulating leucocytes. Norepinephrine was modestly increased while the ratio between plasma dihydroxyphenylglycol (DHPG) and norepinephrine levels, a marker for norepinephrine clearance, was reduced with UFP + O3. Resting MSNA was not different (47 ± 12 with Air, 47 ± 14 with UFP, and 45 ± 14 bursts/min with UFP + O3). Indices of parasympathetic heart rate control were unaffected by experimental air pollution. Our study suggests that combined exposure to modest UFP and O3 levels increases peripheral norepinephrine availability through decreased clearance rather than changes in central autonomic activity. Pulmonary inflammatory response may have perturbed pulmonary endothelial norepinephrine clearance

Item URL in elib:https://elib.dlr.de/129729/
Document Type:Article
Title:Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Heusser, K.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIED
Tank, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Holz, O.Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 30625, Hannover, GermanyUNSPECIFIED
May, M.Hannover Medical School, Hannover, GermanyUNSPECIFIED
Brinkmann, J.Institute for Clinical Pharmacology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Engeli, S.Institute of Clinical Pharmacology, Hannover Medical School, GermanyUNSPECIFIED
Diedrich, A.Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Service, Vanderbilt University, Nashville, TNUNSPECIFIED
Framke, T.Institute for Biometry, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Koch, A.Institute for Biometry, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Großhennig, A.Institute for Biometry, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Danser, A.H.J.Erasmus Medical Center, Rotterdam NetherlandsUNSPECIFIED
Sweep, F.C.G.J.Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, NetherlandsUNSPECIFIED
Schindler, C.Institute for Clinical Pharmacology, MHH, GermanyUNSPECIFIED
Schwarz, K.Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 30625, Hannover, GermanyUNSPECIFIED
Krug, N.Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, GermanyUNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Hohlfeld, J. M.Clinical Airway Research, Fraunhofer ITEM, HannoverUNSPECIFIED
Date:6 March 2019
Journal or Publication Title:Scientific Reports
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:9
DOI :10.1038/s41598-019-40343-w
Page Range:p. 3641
Publisher:Nature Publishing Group
ISSN:2045-2322
Status:Published
Keywords:Cardiovascular; human autonomic Regulation; sympathetic activity
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:23 Oct 2019 10:43
Last Modified:30 Sep 2020 13:45

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Copyright © 2008-2017 German Aerospace Center (DLR). All rights reserved.