elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Information-domain method for the quantification of the complexity of the sympathetic baroreflex regulation in healthy subjects and amyotrophic lateral sclerosis patients

Cairo, B. and De Maria, B. and Bari, V. and Vaini, E. and Heusser, K. and Tank, J. and Jordan, J. and Barbic, F. and Furlan, R. and Marinou, K. and Vecchia, L. and Porta, A. (2019) Information-domain method for the quantification of the complexity of the sympathetic baroreflex regulation in healthy subjects and amyotrophic lateral sclerosis patients. Physiological Measurement, 40 (3). Institute of Physics (IOP) Publishing. DOI: 10.1088/1361-6579/ab0d4b ISSN 0967-3334

Full text not available from this repository.

Official URL: https://iopscience.iop.org/article/10.1088/1361-6579/ab0d4b

Abstract

BACKGROUND: The sympathetic baroreflex (sBR) adjusts muscle sympathetic nerve activity (MSNA) in response to arterial pressure changes but the relevance of assessing sBR control complexity is unclear. OBJECTIVE: We propose a method for the evaluation of sBR control complexity. APPROACH: The approach comprises the quantification of complexity of the sBR latency regulation and the assessment of complexity of the relationship linking MSNA burst to R-wave peak regardless of the variability of the sBR latency. The Shannon entropy (SE) of the sBR latency distribution is taken as an estimate of complexity of the sBR latency regulation. The conditional entropy (CE) of the beat-to-beat binary series obtained by coding the presence/absence of the MSNA burst after an R-wave peak is taken as an estimate of complexity of the sBR control regardless of the sBR latency variability. Surrogate analysis was utilized to set the level of inactive or impaired sBR. The approach was applied to 10 young healthy subjects undergoing head-up tilt (HUT) followed by lower body negative pressure to evoke presyncope (preSYNC) before and after 21 d head-down bed rest (HDBR), and to five amyotrophic lateral sclerosis (ALS) patients undergoing HUT. MAIN RESULTS: In healthy subjects the surrogate analysis suggested that HUT and preSYNC significantly activated the sBR control but its response was weakened after 21 d HDBR. During preSYNC sBR latency increased significantly only after 21 d HDBR. In ALS patients the complexity of the sBR latency regulation was close to the level set by surrogate analysis and HUT did not trigger any sBR control response. SIGNIFICANCE: The proposed method for sBR control complexity quantification was useful in detecting the impairment of the sBR control after 21 d HDBR in healthy subjects and the dysfunction of the sBR regulation in ALS patients.

Item URL in elib:https://elib.dlr.de/129723/
Document Type:Article
Title:Information-domain method for the quantification of the complexity of the sympathetic baroreflex regulation in healthy subjects and amyotrophic lateral sclerosis patients
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Cairo, B.Department of Biomedical Sciences for Health, University of Milan, ItalyUNSPECIFIED
De Maria, B.IRCCS Istituti Clinici Scientifici Maugeri, Milan, ItalyUNSPECIFIED
Bari, V.Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, ItalyUNSPECIFIED
Vaini, E.Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, ItalyUNSPECIFIED
Heusser, K.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIED
Tank, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Barbic, F.Department of Internal Medicine, Humanitas Clinical and Research Center, Rozzano (MI), Humanitas University, Rozzano, ItalyUNSPECIFIED
Furlan, R.Department of Internal Medicine, Humanitas Clinical and Research Center, Rozzano (MI), Humanitas University, Rozzano, ItalyUNSPECIFIED
Marinou, K.IRCCS Istituti Clinici Scientifici Maugeri, Milan, ItalyUNSPECIFIED
Vecchia, L.IRCCS Istituti Clinici Scientifici Maugeri, Milan, ItalyUNSPECIFIED
Porta, A.Department of Biomedical Sciences for Health, University of Milan, Italy;Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico di San Donato, San Donato Milanese, ItalyUNSPECIFIED
Date:29 March 2019
Journal or Publication Title:Physiological Measurement
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:40
DOI :10.1088/1361-6579/ab0d4b
Publisher:Institute of Physics (IOP) Publishing
ISSN:0967-3334
Status:Published
Keywords:sympathetic baroreflex ;healthy subjects ;amyotrophic lateral sclerosis patients; muscle sympathetic nerve activity
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Deposited By: Schrage, Larissa
Deposited On:23 Oct 2019 10:33
Last Modified:23 Oct 2019 10:33

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Copyright © 2008-2017 German Aerospace Center (DLR). All rights reserved.