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Space Station conditions are selective but do not alter microbial characteristics relevant to human health

Mora, Maximilian and Wink, Lisa and Kögler, Ines and Mahnert, Alexander and Rettberg, Petra and Schwendner, Petra and Demets, René and Cockell, Charles and Alekhova, Tatiana and Klingl, Andreas and Krause, Robert and Zolotariof, Anna and Alexandrova, Alina and Moissl-Eichinger, Christine (2019) Space Station conditions are selective but do not alter microbial characteristics relevant to human health. Nature Communications, 10 (1), p. 3990. Nature Publishing Group. doi: 10.1038/s41467-019-11682-z. ISSN 2041-1723.

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Official URL: http://dx.doi.org/10.1038/s41467-019-11682-z

Abstract

The International Space Station (ISS) is a unique habitat for humans and microorganisms. Here, we report the results of the ISS experiment EXTREMOPHILES, including the analysis of microbial communities from several areas aboard at three time points. We assess microbial diversity, distribution, functional capacity and resistance profile using a combination of cultivation-independent analyses (amplicon and shot-gun sequencing) and cultivationdependent analyses (physiological and genetic characterization of microbial isolates, antibiotic resistance tests, co-incubation experiments). We show that the ISS microbial communities are highly similar to those present in ground-based confined indoor environments and are subject to fluctuations, although a core microbiome persists over time and locations. The genomic and physiological features selected by ISS conditions do not appear to be directly relevant to human health, although adaptations towards biofilm formation and surface interactions were observed. Our results do not raise direct reason for concern with respect to crew health, but indicate a potential threat towards material integrity in moist areas.

Item URL in elib:https://elib.dlr.de/129124/
Document Type:Article
Title:Space Station conditions are selective but do not alter microbial characteristics relevant to human health
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Mora, MaximilianMedical University of Graz, Department of Internal Medicine, Auenbruggerplatz 15, 8036 Graz, Austria.UNSPECIFIED
Wink, LisaMedical University of Graz, Department of Internal Medicine, Auenbruggerplatz 15, 8036 Graz, Austria.UNSPECIFIED
Kögler, InesMedical University of Graz, Department of Internal Medicine, Auenbruggerplatz 15, 8036 Graz, Austria.UNSPECIFIED
Mahnert, AlexanderMedical University of Graz, Department of Internal Medicine, Auenbruggerplatz 15, 8036 Graz, Austria.UNSPECIFIED
Rettberg, PetraRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; petra.rettberg (at) dlr.dehttps://orcid.org/0000-0003-4439-2395
Schwendner, PetraUniversity of Edinburgh, School of Physics and Astronomy, James Clerk Maxwell Building, Peter Guthrie Tait Road, Edinburgh EH9 3FD, UKUNSPECIFIED
Demets, RenéEuropean Space Research and Technology Centre (ESTEC), Keplerlaan 1, 2201 AZ Noordwijk, The Netherlands.UNSPECIFIED
Cockell, CharlesUniversity of Edinburgh, School of Physics and Astronomy, James Clerk Maxwell Building, Peter Guthrie Tait Road, Edinburgh EH9 3FD, UKhttps://orcid.org/0000-0003-3662-0503
Alekhova, TatianaLomonosov Moscow State University, Biological Faculty, ul. Leninskiye Gory, 1, стр. 12 Moscow, Russia.UNSPECIFIED
Klingl, AndreasLudwig Maximilians University of Munich, Plant Development and Electron Microscopy, Department of Biology I, Biocenter, Großhaderner Str. 2, 82152 Planegg-Martinsried, GermanyUNSPECIFIED
Krause, RobertMedical University of Graz, Department of Internal Medicine, Auenbruggerplatz 15, 8036 Graz, Austria and BioTechMed Graz, Mozartgasse 12/II, 8010 Graz, Austria.UNSPECIFIED
Zolotariof, AnnaUniversity of Edinburgh, School of Physics and Astronomy, James Clerk Maxwell Building, Peter Guthrie Tait Road, Edinburgh EH9 3FD, UKhttps://orcid.org/0000-0002-0120-3753
Alexandrova, AlinaLomonosov Moscow State University, Biological Faculty, ul. Leninskiye Gory, 1, стр. 12Lomonosov Moscow State University, Biological Faculty, ul. Leninskiye Gory, 1, стр. 12 Moscow, Russia.UNSPECIFIED
Moissl-Eichinger, ChristineMedical University of Graz, Department of Internal Medicine, Auenbruggerplatz 15, 8036 Graz, Austria and BioTechMed Graz, Mozartgasse 12/II, 8010 Graz, Austria.UNSPECIFIED
Date:5 September 2019
Journal or Publication Title:Nature Communications
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:10
DOI:10.1038/s41467-019-11682-z
Page Range:p. 3990
Publisher:Nature Publishing Group
ISSN:2041-1723
Status:Published
Keywords:ISS, EXTREMOPHILES, microbial communities, human health
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:20 Sep 2019 11:35
Last Modified:30 Sep 2020 14:42

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