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Disuse impairs the mechanical competence of bone by regulating the characterizations of mineralized collagen fibrils in cortical bone

Yang, P. and Nie, X.-T. and Wang, Z. and Al-Qudsy, L.H.H. and Ren, L. and Xu, H.-Y. and Rittweger, J. and Shang, P. (2019) Disuse impairs the mechanical competence of bone by regulating the characterizations of mineralized collagen fibrils in cortical bone. Frontiers in Physiology, 10, p. 775. Frontiers Media S.A. DOI: 10.3389/fphys.2019.00775 ISSN 1664-042X

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Official URL: http://www.frontiersin.org

Abstract

Bones are made of complex material comprising organic components and mineral hydroxyapatite, both of which formulate the unique hierarchical structure of bone and its mechanical properties. Bones are capable of optimizing their structure and mechanical properties according to the mechanical environment. Mineral loss is a well-known consequence of skeleton disuse. By contrast, the response of the non-mineral phase of bone, i.e., the collagen network, during disuse remain largely unknown. In this study, a tail-suspension mice model was used to induce bone loss. Atomic force microscopybased imaging and indentation approaches were adopted to investigate the influence of disuse on the morphology and in situ mechanical behavior of the collagen fibrils, under both non-loaded and load-bearing conditions, in the cortical tibia of mice. The results indicate that disuse induced by hindlimb unloading did not alter the orientation and D-periodic spacing of the collagen fibril, but results in decreased collagen crosslinking which correlates with decreased elasticity and increased susceptibility to mechanical damage. More concretely, the collagen fibrils in the disused tibia were misaligned under mechanical loading. It therefore indicates that the disordered arrangement of the mineralized collagen fibrils is one of the characteristics of the weakened bone during elastic deformation. These findings reveals the unique adaptation regimes of the collagen fibrils in the cortical bone to disuse, as well as the deformation mechanisms of bone in the relevant pathological process at different scales.

Item URL in elib:https://elib.dlr.de/128808/
Document Type:Article
Title:Disuse impairs the mechanical competence of bone by regulating the characterizations of mineralized collagen fibrils in cortical bone
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Yang, P.Division Space Physiology, Institute of Aerospace Medicine, German Aerospace Center, Cologne, Pengfei.Yang (at) dlr.deUNSPECIFIED
Nie, X.-T.UNSPECIFIEDUNSPECIFIED
Wang, Z.UNSPECIFIEDUNSPECIFIED
Al-Qudsy, L.H.H.UNSPECIFIEDUNSPECIFIED
Ren, L.UNSPECIFIEDUNSPECIFIED
Xu, H.-Y.UNSPECIFIEDUNSPECIFIED
Rittweger, J.Joern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Shang, P.Northwestern Polytechnical University,Xi'an, ChinaUNSPECIFIED
Date:21 June 2019
Journal or Publication Title:Frontiers in Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:10
DOI :10.3389/fphys.2019.00775
Page Range:p. 775
Publisher:Frontiers Media S.A
ISSN:1664-042X
Status:Published
Keywords:collagen fibril, bone, disuse, mechanical properties, atomic force microscopy
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:22 Aug 2019 11:12
Last Modified:30 Sep 2020 19:08

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