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Fighting Thyroid Cancer with Microgravity Research

Krüger, Marcus and Melnik, Daniela and Kopp, Sascha and Buken, Christoph and Sahana, Jayashree and Bauer, Johann and Wehland, Markus and Hemmersbach, Ruth and Corydon, Thoma J. and Infanger, Manfred and Grimm, Daniela (2019) Fighting Thyroid Cancer with Microgravity Research. International Journal of Molecular Sciences, 20 (2553), pp. 1-21. Multidisciplinary Digital Publishing Institute (MDPI). DOI: 10.3390/ijms20102553 ISSN 1661-6596

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Official URL: https://www.mdpi.com/1422-0067/20/10/2553

Abstract

Microgravity in space or simulated by special ground-based devices provides an unusual but unique environment to study and influence tumour cell processes. By investigating thyroid cancer cells in microgravity for nearly 20 years, researchers got insights into tumour biology that had not been possible under normal laboratory conditions: adherently growing cancer cells detach from their surface and form three-dimensional structures. The cells included in these multicellular spheroids (MCS) were not only altered but behave also differently to those grown in flat sheets in normal gravity, more closely mimicking the conditions in the human body. Therefore, MCS became an invaluable model for studying metastasis and developing new cancer treatment strategies via drug targeting. Microgravity intervenes deeply in processes such as apoptosis and in structural changes involving the cytoskeleton and the extracellular matrix, which influence cell growth. Most interestingly, follicular thyroid cancer cells grown under microgravity conditions were shifted towards a less-malignant phenotype. Results from microgravity research can be used to rethink conventional cancer research and may help to pinpoint the cellular changes that cause cancer. This in turn could lead to novel therapies that will enhance the quality of life for patients or potentially develop new preventive countermeasures

Item URL in elib:https://elib.dlr.de/128276/
Document Type:Article
Title:Fighting Thyroid Cancer with Microgravity Research
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Krüger, MarcusOtto von Guericke University, Clinic for Plastic, Aesthetic and Hand Surgery, Magdeburg, Germanyhttps://orcid.org/0000-0003-1120-0246
Melnik, DanielaOtto von Guericke University, Clinic for Plastic, Aesthetic and Hand Surgery, Magdeburg, GermanyUNSPECIFIED
Kopp, SaschaOtto von Guericke University, Clinic for Plastic, Aesthetic and Hand Surgery, Magdeburg, Germanyhttps://orcid.org/0000-0001-5829-6455
Buken, ChristophOtto von Guericke University, Clinic for Plastic, Aesthetic and Hand Surgery, Magdeburg, Germany and Aarhus University, Department of Biomedicine, Aarhus, DenmarkUNSPECIFIED
Sahana, JayashreeAarhus University, Institute of Biomedicine, Aarhus, Denmarkhttps://orcid.org/0000-0002-6606-6315
Bauer, JohannMax Planck Institute for Biochemistry, Martinsried, GermanyUNSPECIFIED
Wehland, MarkusOtto von Guericke University, Clinic for Plastic, Aesthetic and Hand Surgery, Magdeburg, GermanyUNSPECIFIED
Hemmersbach, RuthGerman Aerospace Centre (DLR), Institute of Aerospace Medicine, Gravitational Biology, Cologne, Germanyhttps://orcid.org/0000-0001-5308-6715
Corydon, Thoma J.Aarhus University, Department of Biomedicine, Aarhus, Denmarkhttps://orcid.org/0000-0003-3588-6350
Infanger, ManfredOtto von Guericke University, Clinic for Plastic, Aesthetic and Hand Surgery, Magdeburg, GermanyUNSPECIFIED
Grimm, DanielaOtto von Guericke University, Clinic for Plastic, Aesthetic and Hand Surgery, Magdeburg, Germany and Aarhus University, Department of Biomedicine, Aarhus, Denmarkhttps://orcid.org/0000-0002-5083-2812
Date:24 May 2019
Journal or Publication Title:International Journal of Molecular Sciences
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:20
DOI :10.3390/ijms20102553
Page Range:pp. 1-21
Publisher:Multidisciplinary Digital Publishing Institute (MDPI)
ISSN:1661-6596
Status:Published
Keywords:Microgravity, Three-dimensional growth, Spheroids, Aggressiveness, Metastasis, Signal transduction, Cytokines, Target
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Biowissenschaftliche Exp.-vorbereitung, R - Vorhaben Biowissenschaftliche Nutzerunterstützung
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Gravitational Biology
Deposited By: Duwe, Helmut
Deposited On:14 Aug 2019 09:58
Last Modified:14 Aug 2019 09:58

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