Krüger, Marcus und Melnik, Daniela und Kopp, Sascha und Buken, Christoph und Sahana, Jayashree und Bauer, Johann und Wehland, Markus und Hemmersbach, Ruth und Corydon, Thoma J. und Infanger, Manfred und Grimm, Daniela (2019) Fighting Thyroid Cancer with Microgravity Research. International Journal of Molecular Sciences, 20 (10), Seite 2553. Multidisciplinary Digital Publishing Institute (MDPI). doi: 10.3390/ijms20102553. ISSN 1661-6596.
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Offizielle URL: https://www.mdpi.com/1422-0067/20/10/2553
Kurzfassung
Microgravity in space or simulated by special ground-based devices provides an unusual but unique environment to study and influence tumour cell processes. By investigating thyroid cancer cells in microgravity for nearly 20 years, researchers got insights into tumour biology that had not been possible under normal laboratory conditions: adherently growing cancer cells detach from their surface and form three-dimensional structures. The cells included in these multicellular spheroids (MCS) were not only altered but behave also differently to those grown in flat sheets in normal gravity, more closely mimicking the conditions in the human body. Therefore, MCS became an invaluable model for studying metastasis and developing new cancer treatment strategies via drug targeting. Microgravity intervenes deeply in processes such as apoptosis and in structural changes involving the cytoskeleton and the extracellular matrix, which influence cell growth. Most interestingly, follicular thyroid cancer cells grown under microgravity conditions were shifted towards a less-malignant phenotype. Results from microgravity research can be used to rethink conventional cancer research and may help to pinpoint the cellular changes that cause cancer. This in turn could lead to novel therapies that will enhance the quality of life for patients or potentially develop new preventive countermeasures
elib-URL des Eintrags: | https://elib.dlr.de/128276/ | ||||||||||||||||||||||||||||||||||||||||||||||||
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Dokumentart: | Zeitschriftenbeitrag | ||||||||||||||||||||||||||||||||||||||||||||||||
Titel: | Fighting Thyroid Cancer with Microgravity Research | ||||||||||||||||||||||||||||||||||||||||||||||||
Autoren: |
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Datum: | 24 Mai 2019 | ||||||||||||||||||||||||||||||||||||||||||||||||
Erschienen in: | International Journal of Molecular Sciences | ||||||||||||||||||||||||||||||||||||||||||||||||
Referierte Publikation: | Ja | ||||||||||||||||||||||||||||||||||||||||||||||||
Open Access: | Ja | ||||||||||||||||||||||||||||||||||||||||||||||||
Gold Open Access: | Ja | ||||||||||||||||||||||||||||||||||||||||||||||||
In SCOPUS: | Ja | ||||||||||||||||||||||||||||||||||||||||||||||||
In ISI Web of Science: | Ja | ||||||||||||||||||||||||||||||||||||||||||||||||
Band: | 20 | ||||||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.3390/ijms20102553 | ||||||||||||||||||||||||||||||||||||||||||||||||
Seitenbereich: | Seite 2553 | ||||||||||||||||||||||||||||||||||||||||||||||||
Verlag: | Multidisciplinary Digital Publishing Institute (MDPI) | ||||||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 1661-6596 | ||||||||||||||||||||||||||||||||||||||||||||||||
Status: | veröffentlicht | ||||||||||||||||||||||||||||||||||||||||||||||||
Stichwörter: | Microgravity, Three-dimensional growth, Spheroids, Aggressiveness, Metastasis, Signal transduction, Cytokines, Target | ||||||||||||||||||||||||||||||||||||||||||||||||
HGF - Forschungsbereich: | Luftfahrt, Raumfahrt und Verkehr | ||||||||||||||||||||||||||||||||||||||||||||||||
HGF - Programm: | Raumfahrt | ||||||||||||||||||||||||||||||||||||||||||||||||
HGF - Programmthema: | Forschung unter Weltraumbedingungen | ||||||||||||||||||||||||||||||||||||||||||||||||
DLR - Schwerpunkt: | Raumfahrt | ||||||||||||||||||||||||||||||||||||||||||||||||
DLR - Forschungsgebiet: | R FR - Forschung unter Weltraumbedingungen | ||||||||||||||||||||||||||||||||||||||||||||||||
DLR - Teilgebiet (Projekt, Vorhaben): | R - Vorhaben Biowissenschaftliche Exp.-vorbereitung (alt), R - Vorhaben Biowissenschaftliche Nutzerunterstützung (alt) | ||||||||||||||||||||||||||||||||||||||||||||||||
Standort: | Köln-Porz | ||||||||||||||||||||||||||||||||||||||||||||||||
Institute & Einrichtungen: | Institut für Luft- und Raumfahrtmedizin > Gravitationsbiologie | ||||||||||||||||||||||||||||||||||||||||||||||||
Hinterlegt von: | Duwe, Helmut | ||||||||||||||||||||||||||||||||||||||||||||||||
Hinterlegt am: | 14 Aug 2019 09:58 | ||||||||||||||||||||||||||||||||||||||||||||||||
Letzte Änderung: | 30 Sep 2020 14:20 |
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