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Baumstark-Khan, Christa and Moeller, Ralf and Testard, Isabelle and Saintigny, Yannick and Hellweg, Christine E. (2019) Genotoxic and Cytotoxic Responses of Recombinant Salmonella typhimurium TA1535 Induced by Simulated Space Radiation Qualities. AbSciCon 2019, 2019-06-24 - 2019-06-28, Bellevue, Washington.
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Abstract
Introduction: For risk assessment, mutagenic potential of heavy ions as component of galactic cosmic radiation is of major concern for tumor induction and radiation late effects. Genetically modified TA1535 Salmonella typhimurium (SWITCH) reveal genotoxicity by dose dependent increase of bioluminescence induction and cytotoxicity by dose-dependent decrease in GFP fluorescence. By this, bacterial inactivation and mutation induction by ionizing radiation are analyzed in parallel.
| Item URL in elib: | https://elib.dlr.de/128248/ | ||||||||||||||||||||||||
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| Document Type: | Conference or Workshop Item (Poster) | ||||||||||||||||||||||||
| Title: | Genotoxic and Cytotoxic Responses of Recombinant Salmonella typhimurium TA1535 Induced by Simulated Space Radiation Qualities | ||||||||||||||||||||||||
| Authors: |
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| Date: | 24 June 2019 | ||||||||||||||||||||||||
| Refereed publication: | Yes | ||||||||||||||||||||||||
| Open Access: | Yes | ||||||||||||||||||||||||
| Gold Open Access: | No | ||||||||||||||||||||||||
| In SCOPUS: | No | ||||||||||||||||||||||||
| In ISI Web of Science: | No | ||||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||||
| Keywords: | galactic cosmic radiation, risk assessment, bacterial inactivation and mutation induction | ||||||||||||||||||||||||
| Event Title: | AbSciCon 2019 | ||||||||||||||||||||||||
| Event Location: | Bellevue, Washington | ||||||||||||||||||||||||
| Event Type: | international Conference | ||||||||||||||||||||||||
| Event Start Date: | 24 June 2019 | ||||||||||||||||||||||||
| Event End Date: | 28 June 2019 | ||||||||||||||||||||||||
| HGF - Research field: | Aeronautics, Space and Transport | ||||||||||||||||||||||||
| HGF - Program: | Space | ||||||||||||||||||||||||
| HGF - Program Themes: | Research under Space Conditions | ||||||||||||||||||||||||
| DLR - Research area: | Raumfahrt | ||||||||||||||||||||||||
| DLR - Program: | R FR - Research under Space Conditions | ||||||||||||||||||||||||
| DLR - Research theme (Project): | R - Vorhaben Strahlenbiologie (old) | ||||||||||||||||||||||||
| Location: | Köln-Porz | ||||||||||||||||||||||||
| Institutes and Institutions: | Institute of Aerospace Medicine > Radiation Biology | ||||||||||||||||||||||||
| Deposited By: | Kopp, Kerstin | ||||||||||||||||||||||||
| Deposited On: | 03 Jul 2019 13:03 | ||||||||||||||||||||||||
| Last Modified: | 24 Apr 2024 20:31 |
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