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Photochemistry on the Space Station—Antibody Resistance to Space Conditions after Exposure outside the International Space Station

Coussot, Gaëlle and Le Postollec, Aurélie and Faye, Clément and Baqué, Mickaël and Vandenabeele-Trambouze, Odile and Incerti, Sébastien and Vigier, Flavie and Chaput, Didier and Cottin, Hervé and Przybyla, Bartos and Berger, Thomas and Dobrijevic, Michel (2019) Photochemistry on the Space Station—Antibody Resistance to Space Conditions after Exposure outside the International Space Station. Astrobiology, 19 (8), pp. 1053-1062. Mary Ann Liebert Inc.. doi: 10.1089/ast.2018.1907. ISSN 1531-1074.

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Official URL: http://dx.doi.org/10.1089/ast.2018.1907


Antibody-based analytical instruments are under development to detect signatures of life on planetary bodies. Antibodies are molecular recognition reagents able to detect their target at sub-nanomolar concentrations, with high affinity and specificity. Studying antibody binding performances under space conditions is mandatory to convince space agencies of the adequacy of this promising tool for planetary exploration. To complement previous ground-based experiments on antibody resistance to simulated irradiation, we evaluate in this paper the effects of antibody exposure to real space conditions during the EXPOSE-R2 mission outside the International Space Station. The absorbed dose of ionizing radiation recorded during the 588 days of this mission (220 mGy) corresponded to the absorbed dose expected during a mission to Mars. Moreover, samples faced, at the same time as irradiation, thermal cycles, launch constraints, and long-term storage. A model biochip was used in this study with antibodies in freeze-dried form and under two formats: free or covalently grafted to a solid surface. We found that antibody-binding performances were not significantly affected by cosmic radiation, and more than 40% of the exposed antibody, independent of its format, was still functional during all this experiment. We conclude that antibody-based instruments are well suited for in situ analysis on planetary bodies.

Item URL in elib:https://elib.dlr.de/128232/
Document Type:Article
Title:Photochemistry on the Space Station—Antibody Resistance to Space Conditions after Exposure outside the International Space Station
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Coussot, GaëlleInstitut des Biomolécules Max Mousseron (IBMM), Université de Montpellier, CNRS, ENSCM, Montpellier, FranceUNSPECIFIEDUNSPECIFIED
Le Postollec, AurélieLaboratoire d’Astrophysique de Bordeaux (LAB), Université de Bordeaux, CNRS, Pessac, France.UNSPECIFIEDUNSPECIFIED
Faye, ClémentColcom, Cap Alpha, Clapiers, France.UNSPECIFIEDUNSPECIFIED
Baqué, MickaëlGerman Aerospace Center (DLR), Institute of Planetary Research, Management and Infrastructure, Research Group Astrobiological Laboratories, Berlin, Germany.https://orcid.org/0000-0002-6696-6030UNSPECIFIED
Vandenabeele-Trambouze, OdileUniversité de Bretagne Occidentale (UBO), IUEM—UMR 6197, Laboratoire de Microbiologie des Environnements Extrémes (LMEE), Plouzané, France.UNSPECIFIEDUNSPECIFIED
Incerti, SébastienCentre d’Etudes Nucléaires de Bordeaux Gradignan (CENBG), UMR 5797, Université de Bordeaux, Gradignan, France.UNSPECIFIEDUNSPECIFIED
Vigier, Flavie*This coauthor is now working for private companies.UNSPECIFIEDUNSPECIFIED
Chaput, DidierCentre National d’Etudes Spatiales, DCT/ME/EM, Toulouse, France.UNSPECIFIEDUNSPECIFIED
Cottin, HervéLaboratoire Interuniversitaire des Systémes Atmosphériques (LISA), UMR 7583, Université Paris Est Créteil et Université Paris Diderot, Institut Pierre Simon Laplace, Créteil, France.UNSPECIFIEDUNSPECIFIED
Przybyla, BartosDiderot, Institut Pierre Simon Laplace, Créteil, France.UNSPECIFIEDUNSPECIFIED
Berger, ThomasUNSPECIFIEDhttps://orcid.org/0000-0003-3319-5740UNSPECIFIED
Dobrijevic, MichelLaboratoire d’Astrophysique de Bordeaux (LAB), Université de Bordeaux, CNRS, Pessac, France.UNSPECIFIEDUNSPECIFIED
Date:28 February 2019
Journal or Publication Title:Astrobiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
Page Range:pp. 1053-1062
Publisher:Mary Ann Liebert Inc.
Keywords:Astrobiology, Cosmic rays, Biochip, Antibody, Planetary exploration
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Space Exploration
DLR - Research area:Raumfahrt
DLR - Program:R EW - Space Exploration
DLR - Research theme (Project):R - Exploration of the Solar System, R - Vorhaben Strahlenbiologie (old)
Location: Berlin-Adlershof , Köln-Porz
Institutes and Institutions:Institute of Planetary Research > Leitungsbereich PF
Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:03 Jul 2019 13:00
Last Modified:18 Sep 2019 12:27

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