Coussot, Gaëlle and Le Postollec, Aurélie and Faye, Clément and Baqué, Mickaël and Vandenabeele-Trambouze, Odile and Incerti, Sébastien and Vigier, Flavie and Chaput, Didier and Cottin, Hervé and Przybyla, Bartos and Berger, Thomas and Dobrijevic, Michel (2019) Photochemistry on the Space Station—Antibody Resistance to Space Conditions after Exposure outside the International Space Station. Astrobiology, 19 (8), pp. 1053-1062. Mary Ann Liebert Inc.. doi: 10.1089/ast.2018.1907. ISSN 1531-1074.
Full text not available from this repository.
Official URL: http://dx.doi.org/10.1089/ast.2018.1907
Abstract
Antibody-based analytical instruments are under development to detect signatures of life on planetary bodies. Antibodies are molecular recognition reagents able to detect their target at sub-nanomolar concentrations, with high affinity and specificity. Studying antibody binding performances under space conditions is mandatory to convince space agencies of the adequacy of this promising tool for planetary exploration. To complement previous ground-based experiments on antibody resistance to simulated irradiation, we evaluate in this paper the effects of antibody exposure to real space conditions during the EXPOSE-R2 mission outside the International Space Station. The absorbed dose of ionizing radiation recorded during the 588 days of this mission (220 mGy) corresponded to the absorbed dose expected during a mission to Mars. Moreover, samples faced, at the same time as irradiation, thermal cycles, launch constraints, and long-term storage. A model biochip was used in this study with antibodies in freeze-dried form and under two formats: free or covalently grafted to a solid surface. We found that antibody-binding performances were not significantly affected by cosmic radiation, and more than 40% of the exposed antibody, independent of its format, was still functional during all this experiment. We conclude that antibody-based instruments are well suited for in situ analysis on planetary bodies.
Item URL in elib: | https://elib.dlr.de/128232/ | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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Document Type: | Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Title: | Photochemistry on the Space Station—Antibody Resistance to Space Conditions after Exposure outside the International Space Station | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Authors: |
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Date: | 28 February 2019 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Astrobiology | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Refereed publication: | Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Open Access: | No | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Gold Open Access: | No | ||||||||||||||||||||||||||||||||||||||||||||||||||||
In SCOPUS: | Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||
In ISI Web of Science: | Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Volume: | 19 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1089/ast.2018.1907 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Page Range: | pp. 1053-1062 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Publisher: | Mary Ann Liebert Inc. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 1531-1074 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Status: | Published | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Keywords: | Astrobiology, Cosmic rays, Biochip, Antibody, Planetary exploration | ||||||||||||||||||||||||||||||||||||||||||||||||||||
HGF - Research field: | Aeronautics, Space and Transport | ||||||||||||||||||||||||||||||||||||||||||||||||||||
HGF - Program: | Space | ||||||||||||||||||||||||||||||||||||||||||||||||||||
HGF - Program Themes: | Space Exploration | ||||||||||||||||||||||||||||||||||||||||||||||||||||
DLR - Research area: | Raumfahrt | ||||||||||||||||||||||||||||||||||||||||||||||||||||
DLR - Program: | R EW - Space Exploration | ||||||||||||||||||||||||||||||||||||||||||||||||||||
DLR - Research theme (Project): | R - Exploration of the Solar System, R - Vorhaben Strahlenbiologie (old) | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Location: | Berlin-Adlershof , Köln-Porz | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Institutes and Institutions: | Institute of Planetary Research > Leitungsbereich PF Institute of Aerospace Medicine > Radiation Biology | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Deposited By: | Kopp, Kerstin | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Deposited On: | 03 Jul 2019 13:00 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Last Modified: | 18 Sep 2019 12:27 |
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