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Tensiomyography detects early hallmarks of bed-rest-induced atrophy before changes in muscle architecture

Simunic, B. and Koren, K. and Rittweger, J. and Lazzer, S. and Reggiani, C. and Rejc, E. and Pišot, R. and Narici, M. and Degens, H. (2019) Tensiomyography detects early hallmarks of bed-rest-induced atrophy before changes in muscle architecture. Journal of Applied Physiology, 126 (4), pp. 815-822. American Physiological Society. DOI: 10.1152/japplphysiol.00880.2018 ISSN 8750-7587

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Abstract

In young and older people, skeletal muscle mass is reduced after as little as 7 days of disuse. The declines in muscle mass after such short periods are of high clinical relevance, particularly in older people who show a higher atrophy rate and a slower or even a complete lack of muscle mass recovery after disuse. Ten men (24.3 yr; SD 2.6) underwent 35 days of 6° head-down tilt bed rest, followed by 30 days of recovery. During bed rest, a neutral energy balance was maintained, with three weekly passive physiotherapy sessions to minimize muscle soreness and joint stiffness. All measurements were performed in a hospital at days 1–10, 16, 28, and 35 of bed rest (BR1–BR10, BR16, BR28, and BR35, respectively) and days 1, 3, and 30 after reambulation (R + 1, R + 3, and R + 30, respectively). Vastus medialis obliquus (VMO), vastus medialis longus (VML), and biceps femoris (BF) thickness (d) and pennation angle (Θ) were assessed by ultrasonography, whereas twitch muscle belly displacement (Dm) and contraction time (Tc) were assessed with tensiomyography (TMG). After bed rest, d and Θ decreased by 13–17% in all muscles (P < 0.001) and had recovered at R + 30. Dm was increased by 42.3–84.4% (P < 0.001) at BR35 and preceded the decrease in d by 7, 5, and 3 days in VMO, VML, and BF, respectively. Tc increased only in BF (32.1%; P < 0.001) and was not recovered at R + 30. TMG can detect early bed-rest-induced changes in muscle with higher sensitivity before overt architectural changes, and atrophy can be detected. NEW & NOTEWORTHY Detection of early atrophic processes and irreversible adaptation to disuse are of high clinical relevance. With the use of tensiomyography (TMG), we detected early atrophic processes before overt architectural changes, and atrophy can be detected using imaging technique. Furthermore, TMG detected irreversible changes of biceps femoris contraction time.

Item URL in elib:https://elib.dlr.de/127499/
Document Type:Article
Title:Tensiomyography detects early hallmarks of bed-rest-induced atrophy before changes in muscle architecture
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Simunic, B.University of Primorska, SloveniaUNSPECIFIED
Koren, K.Science and Research Centre Koper, Institute for Kinesiology Research, Koper, SloveniaUNSPECIFIED
Rittweger, J.Joern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Lazzer, S.University of UdineUNSPECIFIED
Reggiani, C.University of Padua, ItalyUNSPECIFIED
Rejc, E.UNSPECIFIEDUNSPECIFIED
Pišot, R.University of PrimorskaUNSPECIFIED
Narici, M.Department of Biomedical Sciences, University of Padova, Padova, ItalyUNSPECIFIED
Degens, H.h.degens (at) mmu.ac.ukUNSPECIFIED
Date:1 April 2019
Journal or Publication Title:Journal of Applied Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:126
DOI :10.1152/japplphysiol.00880.2018
Page Range:pp. 815-822
Publisher:American Physiological Society
ISSN:8750-7587
Status:Published
Keywords:TMG; Vastus medialis obliquus; Vastus medialis obliquus; tensiomyography ; bed rest; skeletal muscle;
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:23 May 2019 12:22
Last Modified:02 Apr 2020 03:00

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