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Lower body negative pressure enhances oxygen availability in the knee extensor muscles during intense resistive exercise in supine position

Parganlija, Dajana and Nieberg, Vita and Sauer, Marc and Rittweger, Jörn and Bloch, Wilhelm and Zange, Jochen (2019) Lower body negative pressure enhances oxygen availability in the knee extensor muscles during intense resistive exercise in supine position. European Journal of Applied Physiology, 119, pp. 1289-1303. Springer. DOI: 10.1007/s00421-019-04113-w ISSN 1439-6319

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Abstract

Purpose During exercise in supine posture or under microgravity in space, the gravity-dependent component of local blood pressure in leg muscles at upright posture can be simulated by lower body negative pressure (LBNP). We hypothesized that during resistive exercise LBNP favors oxygen availability in lower extremities, benefiting energy levels and performance of working muscles. Methods In permutated crossover design, nine subjects performed a series of fifteen slow-paced concentric (4 s) and eccentric contractions (4 s) without or with 40 mmHg LBNP and 4 s pause between repetitions. The force at knee flexion was 6% of the one repetition maximum (1-RM) and gradually increased to 60% 1RM in the first half of the individual range of motion, subsequently remaining constant until full extension. Results During the low force periods of continuous exercise, LBNP enhanced the refill of capillary blood measured by near infrared spectroscopy, amplifying the increase of total haemoglobin by about 20 µmol/l (p < 0.01) and oxyhaemoglobin by about 10 µmol/l (p <0.01). During continuous exercise, LBNP induced a trend towards a lower EMG increment. This LBNP effect was not found when the periods of low forces at knee flexion were extended by 4 s pauses. Increased respiratory oxygen uptake (+ 0.1 l/min, p < 0.05) indicated overall enhanced muscle energy turn-over. Conclusions Our results suggest stimulation of oxidative metabolism through LBNP enables working muscles to meet the energy demands of intense exercise. Further research is needed on the consequences for energy metabolism and the molecular control of growth and differentiation.

Item URL in elib:https://elib.dlr.de/127486/
Document Type:Article
Title:Lower body negative pressure enhances oxygen availability in the knee extensor muscles during intense resistive exercise in supine position
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Parganlija, DajanaSpace Physiology Department, Institute of AerospaceUNSPECIFIED
Nieberg, VitaSpace Physiology Department, Institute of AerospaceUNSPECIFIED
Sauer, MarcSpace Physiology Department, Institute of AerospaceUNSPECIFIED
Rittweger, JörnSpace Physiology Department, Institute of AerospaceUNSPECIFIED
Bloch, WilhelmGerman Sport University Colognehttps://orcid.org/0000-0003-1786-8853
Zange, JochenJochen.Zange (at) dlr.dehttps://orcid.org/0000-0003-1822-0952
Date:March 2019
Journal or Publication Title:European Journal of Applied Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:119
DOI :10.1007/s00421-019-04113-w
Page Range:pp. 1289-1303
Editors:
EditorsEmail
Olfert, I. MarkUNSPECIFIED
Publisher:Springer
ISSN:1439-6319
Status:Published
Keywords:Slow concentric–eccentric resistance exercise; Lower body negative pressure; Simulated orthostasis; Muscle Perfusion; Muscle pump; Leg press;
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:23 May 2019 11:53
Last Modified:06 Sep 2019 15:25

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