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The gravity dependence of pharmacodynamics. The integration of lidocaine into membranes in microgravity

Kohn, Florian P. and Hauslage, Jens (2019) The gravity dependence of pharmacodynamics. The integration of lidocaine into membranes in microgravity. npj Microgravity, 5 (5), pp. 1-6. Nature Publishing Group. DOI: 10.1038/s41526-019-0064-5 ISSN 2373-8065

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Official URL: https://doi.org/10.1038/s41526-019-0064-5

Abstract

To realize long-term manned space missions, e.g. to Mars, some important questions about pharmacology under conditions of different gravity will have to be answered to ensure safe usage of pharmaceuticals. Experiments on the International Space Station showed that the pharmacokinetics of drugs are changed in microgravity. On Earth, it is well known that the incorporation of substances into cellular membranes depends on membrane fluidity, therefore the finding that membrane fluidity is gravity dependent possibly has effects on pharmacodynamics of hydrophobic and amphiphilic substances in microgravity. To validate a possible effect of gravity on pharmacodynamics, experiments have been carried out to investigate the incorporation of lidocaine into plain lipid membranes under microgravity conditions. In microgravity, the induced increase in membrane fluidity associated with lidocaine incorporation is smaller compared to 1g controls. This experiment concerning the gravity dependence of pharmacodynamics in real microgravity clearly shows that the incorporation of amphipathic drugs into membranes is changed in microgravity. This might have significant impact on the pharmacology of drugs during long-term space missions and has to be investigated in more detail to be able to assess possible risks

Item URL in elib:https://elib.dlr.de/127414/
Document Type:Article
Title:The gravity dependence of pharmacodynamics. The integration of lidocaine into membranes in microgravity
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Kohn, Florian P.university of hohenheim, institute of physiology, stuttgart, germanyhttps://orcid.org/0000-0002-3127-3242
Hauslage, Jensgerman aerospace centre (dlr), institute of aerospace medicine, gravitational biology, cologne, germanyhttps://orcid.org/0000-0003-2184-7000
Date:6 March 2019
Journal or Publication Title:npj Microgravity
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:5
DOI :10.1038/s41526-019-0064-5
Page Range:pp. 1-6
Publisher:Nature Publishing Group
ISSN:2373-8065
Status:Published
Keywords:membrane fluidity, gravity dependence, pharmacodynamics, lidocaine, microgravity
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Biowissenschaftliche Exp.-vorbereitung, R - Vorhaben Biowissenschaftliche Nutzerunterstützung
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Gravitational Biology
Deposited By: Duwe, Helmut
Deposited On:23 May 2019 10:15
Last Modified:23 May 2019 10:15

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