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Pressure From the Bugs Within - Gut Microbiota and Human Arterial Hypertension

Jordan, Jens and Moeller, Ralf and Chakraborty, Saroj and Vijay-Kumar, Matam and Joe, Bina (2019) Pressure From the Bugs Within - Gut Microbiota and Human Arterial Hypertension. Hypertension, 73 (5), pp. 977-979. American Heart Association, Inc.. doi: 10.1161/HYPERTENSIONAHA.119.12685. ISSN 0194-911X.

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Official URL: http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12685


The human body houses a large number of diverse outnumbering other organisms such as archaea and fungi bacteria by orders of magnitude. The whole community of organisms is commonly referred to as human microbiota, whereas microbiome is defined as the collective genomes of these organisms. Whereas earlier estimates suggested that the number of bacteria colonizing the human body may exceed the number of human cells 10-fold, more recent estimates suggest that the ratio between bacteria and human cells may be closer to one.1 In any case, the microbial colonization is vast, and it may be no surprise that these microorganisms interact with and affect the human body. The study by Sun et al in this issue illustrates the importance of this interaction for human arterial hypertension (Figure). The gut appears to be particularly important in that regard given its colonization with ≈100 trillion microbial cells comprising >1000 bacterial species, the large surface area, contact to food, and its involvement in local and systemic immune responses. The composition of the gut microbiota is highly variable between subjects because each subject harbors a unique set of microbial species.

Item URL in elib:https://elib.dlr.de/127022/
Document Type:Article
Additional Information:Editorial Commentary
Title:Pressure From the Bugs Within - Gut Microbiota and Human Arterial Hypertension
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Jordan, JensUNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Moeller, RalfUNSPECIFIEDhttps://orcid.org/0000-0002-2371-0676UNSPECIFIED
Date:25 March 2019
Journal or Publication Title:Hypertension
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
Page Range:pp. 977-979
Publisher:American Heart Association, Inc.
Keywords:human arterial hypertension, gut microbiota
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:other
DLR - Research area:Raumfahrt
DLR - Program:R - no assignment
DLR - Research theme (Project):R - no assignment
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Leitungsbereich ME
Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:03 Apr 2019 11:13
Last Modified:08 Nov 2023 10:17

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