Caiani, E.G. and Landreani, F. and Costantini, L. and Mulder, E. and Gerlach, D.A. and Vaida, P. and Migeotte, P.-F. (2018) Mitral and aortic flow adaptation to 58-days head-down bed-rest assessed by PC-MRI, and effectiveness of high-intensity jump training countermeasure. In: EUROPEAN HEART JOURNAL, pp. 162-163. European Society of Cardiology Congress, 2018-08-25 - 2018-08-29, Munich, Germany. doi: 10.1093/eurheartj/ehy564.P874.
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Official URL: https://doi.org/10.1093/eurheartj/ehy564.P874
Abstract
Aims: Prolonged immobilization generates cardiac deconditioning, a cardiovascular disease risk factor, and efficient countermeasures (CM) are needed to prevent it. We aimed to assess by Phase-Contrast (PC) MRI the effects of long-term strict head-down (-6 degrees) bed-rest (BR) deconditioning and the effectiveness of high-intensity jump training CM on aortic and mitral flow. Methods: 23 males (29±6 years, 181±6 cm, 77±7 kg) were enrolled. The experiment was conducted at Envihab research facility as part of the European Space Agency BR studies. Participants were randomly allocated to the jump training group (JUMP, n=12) or to the control group (CTRL, n=11). A typical training session consisted of 4x10 countermovement jumps and 2x10 hops in a horizontal sledge jump system, with 5–6 sessions/week. PC-MRI images (3T Biograph mMR) with interleaved 3-directional velocity encoding (VENC: x and y: 80 cm/s; z: 150 cm/s) were obtained (spatial resolution 1.4x1.4 mm2) at the level of the aortic root, and of the mitral plane, before (PRE) and after 58-days (HDT58) of BR. The resulting planar magnitude data and 3-directional velocity images were semi-automatically analysed with previously validated custom software to compute the following parameters: cardiac output (CO), stroke volume (SV), flow rate (Qpeak), systolic duration (Sys) and heart beat duration (RR), rapid filling (Efill) and inflow rate (Epeak). Results: In CTRL, compared to baseline values, at HDT58 a significant (p<.05, paired t-test) RR (14%) and systolic (10%) shortening, with a decrease in CO (8%), SV (22%), Qpeak (12%), Efilling (26%), Epeak (26%) were observed. In CM, only RR was shortened (8%), together with a decrease in SV (12%), Qpeak (7.5%), Efilling (11%), Epeak (15%).
Item URL in elib: | https://elib.dlr.de/126172/ | ||||||||||||||||||||||||||||||||
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Document Type: | Conference or Workshop Item (Poster) | ||||||||||||||||||||||||||||||||
Title: | Mitral and aortic flow adaptation to 58-days head-down bed-rest assessed by PC-MRI, and effectiveness of high-intensity jump training countermeasure | ||||||||||||||||||||||||||||||||
Authors: |
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Date: | 28 August 2018 | ||||||||||||||||||||||||||||||||
Journal or Publication Title: | EUROPEAN HEART JOURNAL | ||||||||||||||||||||||||||||||||
Refereed publication: | Yes | ||||||||||||||||||||||||||||||||
Open Access: | Yes | ||||||||||||||||||||||||||||||||
Gold Open Access: | No | ||||||||||||||||||||||||||||||||
In SCOPUS: | No | ||||||||||||||||||||||||||||||||
In ISI Web of Science: | Yes | ||||||||||||||||||||||||||||||||
DOI: | 10.1093/eurheartj/ehy564.P874 | ||||||||||||||||||||||||||||||||
Page Range: | pp. 162-163 | ||||||||||||||||||||||||||||||||
Status: | Published | ||||||||||||||||||||||||||||||||
Keywords: | aorta; magnetic resonance imaging; bed rest; fluid flow | ||||||||||||||||||||||||||||||||
Event Title: | European Society of Cardiology Congress | ||||||||||||||||||||||||||||||||
Event Location: | Munich, Germany | ||||||||||||||||||||||||||||||||
Event Type: | international Conference | ||||||||||||||||||||||||||||||||
Event Start Date: | 25 August 2018 | ||||||||||||||||||||||||||||||||
Event End Date: | 29 August 2018 | ||||||||||||||||||||||||||||||||
HGF - Research field: | Aeronautics, Space and Transport | ||||||||||||||||||||||||||||||||
HGF - Program: | Space | ||||||||||||||||||||||||||||||||
HGF - Program Themes: | Research under Space Conditions | ||||||||||||||||||||||||||||||||
DLR - Research area: | Raumfahrt | ||||||||||||||||||||||||||||||||
DLR - Program: | R FR - Research under Space Conditions | ||||||||||||||||||||||||||||||||
DLR - Research theme (Project): | R - Vorhaben Systemphysiologie (old) | ||||||||||||||||||||||||||||||||
Location: | Köln-Porz | ||||||||||||||||||||||||||||||||
Institutes and Institutions: | Institute of Aerospace Medicine Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace Institute of Aerospace Medicine > Leitungsbereich ME | ||||||||||||||||||||||||||||||||
Deposited By: | Schrage, Larissa | ||||||||||||||||||||||||||||||||
Deposited On: | 11 Jan 2021 14:43 | ||||||||||||||||||||||||||||||||
Last Modified: | 24 Apr 2024 20:30 |
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