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Mitral and aortic flow adaptation to 58-days head-down bed-rest assessed by PC-MRI, and effectiveness of high-intensity jump training countermeasure

Caiani, E.G. and Landreani, F. and Costantini, L. and Mulder, E. and Gerlach, D.A. and Vaida, P. and Migeotte, P.-F. (2018) Mitral and aortic flow adaptation to 58-days head-down bed-rest assessed by PC-MRI, and effectiveness of high-intensity jump training countermeasure. In: EUROPEAN HEART JOURNAL, pp. 162-163. European Society of Cardiology Congress, 2018-08-25 - 2018-08-29, Munich, Germany. doi: 10.1093/eurheartj/ehy564.P874.

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Official URL: https://doi.org/10.1093/eurheartj/ehy564.P874


Aims: Prolonged immobilization generates cardiac deconditioning, a cardiovascular disease risk factor, and efficient countermeasures (CM) are needed to prevent it. We aimed to assess by Phase-Contrast (PC) MRI the effects of long-term strict head-down (-6 degrees) bed-rest (BR) deconditioning and the effectiveness of high-intensity jump training CM on aortic and mitral flow. Methods: 23 males (29±6 years, 181±6 cm, 77±7 kg) were enrolled. The experiment was conducted at Envihab research facility as part of the European Space Agency BR studies. Participants were randomly allocated to the jump training group (JUMP, n=12) or to the control group (CTRL, n=11). A typical training session consisted of 4x10 countermovement jumps and 2x10 hops in a horizontal sledge jump system, with 5–6 sessions/week. PC-MRI images (3T Biograph mMR) with interleaved 3-directional velocity encoding (VENC: x and y: 80 cm/s; z: 150 cm/s) were obtained (spatial resolution 1.4x1.4 mm2) at the level of the aortic root, and of the mitral plane, before (PRE) and after 58-days (HDT58) of BR. The resulting planar magnitude data and 3-directional velocity images were semi-automatically analysed with previously validated custom software to compute the following parameters: cardiac output (CO), stroke volume (SV), flow rate (Qpeak), systolic duration (Sys) and heart beat duration (RR), rapid filling (Efill) and inflow rate (Epeak). Results: In CTRL, compared to baseline values, at HDT58 a significant (p<.05, paired t-test) RR (14%) and systolic (10%) shortening, with a decrease in CO (8%), SV (22%), Qpeak (12%), Efilling (26%), Epeak (26%) were observed. In CM, only RR was shortened (8%), together with a decrease in SV (12%), Qpeak (7.5%), Efilling (11%), Epeak (15%).

Item URL in elib:https://elib.dlr.de/126172/
Document Type:Conference or Workshop Item (Poster)
Title:Mitral and aortic flow adaptation to 58-days head-down bed-rest assessed by PC-MRI, and effectiveness of high-intensity jump training countermeasure
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Caiani, E.G.Politecnico di Milano, Biomed. Eng. Dpt.UNSPECIFIEDUNSPECIFIED
Landreani, F.Politecnico di Milano, Biomed. Eng. Dpt.UNSPECIFIEDUNSPECIFIED
Costantini, L.Citta Di Lecce Hospital, GVM Care& Research, Lecce, ItalyUNSPECIFIEDUNSPECIFIED
Mulder, E.German Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Gerlach, D.A.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germanyhttps://orcid.org/0000-0001-7044-6065UNSPECIFIED
Vaida, P.Université Bordeaux Segalen, FranceUNSPECIFIEDUNSPECIFIED
Migeotte, P.-F.Université libre de Bruxelles (ULB), Brussels, BelgiumUNSPECIFIEDUNSPECIFIED
Date:28 August 2018
Journal or Publication Title:EUROPEAN HEART JOURNAL
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In ISI Web of Science:Yes
Page Range:pp. 162-163
Keywords:aorta; magnetic resonance imaging; bed rest; fluid flow
Event Title:European Society of Cardiology Congress
Event Location:Munich, Germany
Event Type:international Conference
Event Start Date:25 August 2018
Event End Date:29 August 2018
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:11 Jan 2021 14:43
Last Modified:24 Apr 2024 20:30

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