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Mitral and aortic flow adaptation to 58-days head-down bed-rest assessed by PC-MRI, and effectiveness of high-intensity jump training countermeasure

Caiani, E.G. and Landreani, F. and Costantini, L. and Mulder, E. and Gerlach, D.A. and Vaida, P. and Migeotte, P.-F. (2018) Mitral and aortic flow adaptation to 58-days head-down bed-rest assessed by PC-MRI, and effectiveness of high-intensity jump training countermeasure. In: EUROPEAN HEART JOURNAL, pp. 162-163. European Society of Cardiology Congress, 25.-29. August 2018, Munich, Germany. doi: 10.1093/eurheartj/ehy564.P874.

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Official URL: https://doi.org/10.1093/eurheartj/ehy564.P874

Abstract

Aims: Prolonged immobilization generates cardiac deconditioning, a cardiovascular disease risk factor, and efficient countermeasures (CM) are needed to prevent it. We aimed to assess by Phase-Contrast (PC) MRI the effects of long-term strict head-down (-6 degrees) bed-rest (BR) deconditioning and the effectiveness of high-intensity jump training CM on aortic and mitral flow. Methods: 23 males (29±6 years, 181±6 cm, 77±7 kg) were enrolled. The experiment was conducted at Envihab research facility as part of the European Space Agency BR studies. Participants were randomly allocated to the jump training group (JUMP, n=12) or to the control group (CTRL, n=11). A typical training session consisted of 4x10 countermovement jumps and 2x10 hops in a horizontal sledge jump system, with 5–6 sessions/week. PC-MRI images (3T Biograph mMR) with interleaved 3-directional velocity encoding (VENC: x and y: 80 cm/s; z: 150 cm/s) were obtained (spatial resolution 1.4x1.4 mm2) at the level of the aortic root, and of the mitral plane, before (PRE) and after 58-days (HDT58) of BR. The resulting planar magnitude data and 3-directional velocity images were semi-automatically analysed with previously validated custom software to compute the following parameters: cardiac output (CO), stroke volume (SV), flow rate (Qpeak), systolic duration (Sys) and heart beat duration (RR), rapid filling (Efill) and inflow rate (Epeak). Results: In CTRL, compared to baseline values, at HDT58 a significant (p<.05, paired t-test) RR (14%) and systolic (10%) shortening, with a decrease in CO (8%), SV (22%), Qpeak (12%), Efilling (26%), Epeak (26%) were observed. In CM, only RR was shortened (8%), together with a decrease in SV (12%), Qpeak (7.5%), Efilling (11%), Epeak (15%).

Item URL in elib:https://elib.dlr.de/126172/
Document Type:Conference or Workshop Item (Poster)
Title:Mitral and aortic flow adaptation to 58-days head-down bed-rest assessed by PC-MRI, and effectiveness of high-intensity jump training countermeasure
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Caiani, E.G.Politecnico di Milano, Biomed. Eng. Dpt.UNSPECIFIED
Landreani, F.Politecnico di Milano, Biomed. Eng. Dpt.UNSPECIFIED
Costantini, L.Citta Di Lecce Hospital, GVM Care& Research, Lecce, ItalyUNSPECIFIED
Mulder, E.German Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, GermanyUNSPECIFIED
Gerlach, D.A.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germanyhttps://orcid.org/0000-0001-7044-6065
Vaida, P.Université Bordeaux Segalen, FranceUNSPECIFIED
Migeotte, P.-F.Université libre de Bruxelles (ULB), Brussels, BelgiumUNSPECIFIED
Date:28 August 2018
Journal or Publication Title:EUROPEAN HEART JOURNAL
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:Yes
DOI :10.1093/eurheartj/ehy564.P874
Page Range:pp. 162-163
Status:Published
Keywords:aorta; magnetic resonance imaging; bed rest; fluid flow
Event Title:European Society of Cardiology Congress
Event Location:Munich, Germany
Event Type:international Conference
Event Dates:25.-29. August 2018
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:11 Jan 2021 14:43
Last Modified:11 Jan 2021 14:43

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