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Characterization of the latency and determinism of sympathetic arm of the baroreflex in healthy subjects and amyotrophic lateral sclerosis patients

Cairo, B. and De Maria, B. and Bari, V. and Vaini, E. and Heusser, K. and Tank, J. and Jordan, J. and Barbic, F. and Furlan, R. and Dalla Vecchia, L. and Porta, A. (2018) Characterization of the latency and determinism of sympathetic arm of the baroreflex in healthy subjects and amyotrophic lateral sclerosis patients. ESGCO 2018, 17.-19. September 2018, Wien, Österreich. (Unpublished)

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Official URL: http://esgco2018.com/program/

Abstract

In humans, muscle sympathetic nerve activity (MSNA) recordings at the peroneal nerve exhibit a stable temporal relationship between baroreceptor engagement and MSNA burst occurrence with sympathetic baroreflex (sBR) latencies ranging from 900 to 1600 ms. However, modifications of the sBR latency and determinism are not sufficiently elucidated, especially in response to a sBR challenge. We propose a method to assess sBR latency and determinism by monitoring post-stimulus time distribution (PST) of the time elapsed between R-wave, detected on the ECG, and MSNA burst occurrence. The mode of the PST (if significantly present) in the range of plausible physiological values was taken as an estimate of the sBR latency. We built a binary series coding the appearance/non-appearance of the MSNA burst associated to the R-wave. The level of sBR determinism was computed by comparing the normalized corrected conditional entropy (NCCE) over the original binary series to the NCCE computed over a surrogate series obtained via random shuffling of the original binary digits. The approach was applied to 10 healthy subjects and 5 amyotrophic lateral sclerosis (ALS) patients at rest in supine condition (REST) and during head-up tilt (TILT). In the healthy population, NCCE was found significantly lower in surrogates than in the original series (0.826±0.069 vs 0.877±0.053, p<0.001). The PST distribution had a clear peak centered at 1198±35 ms and 1212±40 ms at REST and during TILT respectively. Conversely, ALS patients did not show a significant separation between original and surrogates series and a clear peak in the PST distribution. Our findings indicate that in healthy individuals, there is a certain degree of determinism in the appearance of MSNA bursts with highly repeatable sBR latencies, while these features are lost in ALS patients.

Item URL in elib:https://elib.dlr.de/126104/
Document Type:Conference or Workshop Item (Other)
Title:Characterization of the latency and determinism of sympathetic arm of the baroreflex in healthy subjects and amyotrophic lateral sclerosis patients
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Cairo, B.Department of Biomedical Sciences for Health, University of Milan, Milan, ItalyUNSPECIFIED
De Maria, B.IRCCS Istituti Clinici Scientifici Maugeri, Milan, ItalyUNSPECIFIED
Bari, V.Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, ItalyUNSPECIFIED
Vaini, E.Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, ItalyUNSPECIFIED
Heusser, K.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Tank, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Barbic, F.Internal Medicine and Syncope Unit, Humanitas Research Hospital, Rozzano, ItalyUNSPECIFIED
Furlan, R.Internal Medicine and Syncope Unit, Humanitas Research Hospital, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Rozzano, ItalyUNSPECIFIED
Dalla Vecchia, L.IRCCS Istituti Clinici Scientifici Maugeri, Milan, ItalyUNSPECIFIED
Porta, A.Department of Biomedical Sciences for Health, University of Milan, Milan, Italy; Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, ItalyUNSPECIFIED
Date:September 2018
Refereed publication:No
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Unpublished
Keywords:latency; determinism; baroreflex; lateral sclerosis patients
Event Title:ESGCO 2018
Event Location:Wien, Österreich
Event Type:international Conference
Event Dates:17.-19. September 2018
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Schrage, Larissa
Deposited On:24 Jan 2019 10:56
Last Modified:31 Jul 2019 20:24

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