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The efficacy of electrical baroreflex activation therapy is independent of peripheral chemoreceptor modulation

Heusser, K. and Thöne, A. and Lipp, A. and Menne, J. and Beige, J. and Reuter, H. and Hoffmann, F. and Halbach, M. and Eckert, S. and Wallbach, M. and Koziolek, M. and Haarmann, H. and Joyner, M. and Paton, J.F.R. and Diedrich, A. and Haller, H. and Jordan, J. and Tank, J. (2018) The efficacy of electrical baroreflex activation therapy is independent of peripheral chemoreceptor modulation. FASEB JOURNAL, 28. Federation of American Societies for Experimental Biology. ISSN 0892-6638

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Official URL: https://www.fasebj.org/doi/abs/10.1096/fasebj.2018.32.1_supplement.884.6

Abstract

Baroreflex activation through electrical carotid sinus stimulation has been developed for the treatment of patients with arterial hypertension not sufficiently responding to pharmacological therapy. Previous studies suggested that peripheral chemoreflex afferents located in proximity to carotid baroreceptors are tonically active in hypertensive patients and may inhibit baroreflex responses. Therefore, we hypothesized that peripheral chemoreflex activation attenuates the efficacy of electrical carotid sinus stimulation.

Item URL in elib:https://elib.dlr.de/126087/
Document Type:Article
Title:The efficacy of electrical baroreflex activation therapy is independent of peripheral chemoreceptor modulation
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Heusser, K.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Thöne, A.Clinical Research Center, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Lipp, A.Department of Neurology, Charité University-Medicine Berlin, Berlin, GermanyUNSPECIFIED
Menne, J.Department of Nephrology and Hypertension, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Beige, J.Department of Nephrology and KfH Renal Unit, Hospital St. Georg Leipzig, Leipzig, GermanyUNSPECIFIED
Reuter, H.Department of Internal Medicine and Cardiology, Evangelisches Klinikum Köln Weyertal, CologneUNSPECIFIED
Hoffmann, F.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Halbach, M.Department of Cardiology, Pneumology, and Angiology, Heart Center of the University of Cologne, Cologne, GermanyUNSPECIFIED
Eckert, S.Department of Cardiology, Heart and Diabetes Centre North Rhine-Westphalia, University Hospital, Ruhr University Bochum, Bad Oeynhausen, GermanyUNSPECIFIED
Wallbach, M.Department of Nephrology & Rheumatology, University Medical Center Göttingen, Göttingen, GermanyUNSPECIFIED
Koziolek, M.Department of Nephrology & Rheumatology, University Medical Center Göttingen, Göttingen, GermanyUNSPECIFIED
Haarmann, H.Clinic for Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, GermanyUNSPECIFIED
Joyner, M.Department of Anesthesiology, Mayo Clinic, Rochester, Rochester, MNUNSPECIFIED
Paton, J.F.R.School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United KingdomUNSPECIFIED
Diedrich, A.Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Service, Vanderbilt University, Nashville, TNUNSPECIFIED
Haller, H.Department of Nephrology and Hypertension, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Tank, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Date:20 April 2018
Journal or Publication Title:FASEB JOURNAL
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:28
Publisher:Federation of American Societies for Experimental Biology
ISSN:0892-6638
Status:Published
Keywords:Baroreflex activation; therapy; peripheral chemoreceptor modulation
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Schrage, Larissa
Deposited On:24 Jan 2019 10:40
Last Modified:24 Jan 2019 10:40

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