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Methods for Gravitational Biology Research

Hemmersbach, Ruth and Häder, Donat-Peter and Braun, Markus (2018) Methods for Gravitational Biology Research. In: Gravitational Biology I. Gravity Sensing and Graviorientation in Microorganism and Plants SpringerBriefs in Space Life Sciences. Springer Nature. pp. 13-26. doi: 10.1007/978-3-319-93894-3_2. ISBN 978-3-319-93893-6. ISSN 2196-5560.

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Official URL: https://link.springer.com/chapter/10.1007/978-3-319-93894-3_2


To study the impact of gravity on living systems on the cellular up to the organismic level, a variety of experimental platforms are available for gravitational biology and biomedical research providing either an almost stimulus-free microgravity environment (near weightlessness) of different duration and boundary conditions. The spectrum of real-microgravity research platforms is complemented by devices which are used to either increase the gravity level (centrifuges) or modify the impact of gravity on biological systems (clinostats and random-positioning machines) the so-called ground-based facilities. Rotating biological samples horizontally or in a two- or three-dimensional mode is often used to randomize the effect of gravity in the attempt to eliminate the gravity effect on sensing mechanisms and gravity-related responses. Sophisticated centrifuges have been designed allowing studies from cells up to humans, either on ground under hypergravity conditions (> 1 g) or in space, where they offer the chance to stepwise increase the acceleration force from 0 g (microgravity) to 1 g or higher and vice versa. In such a way, centrifuges are used to determine threshold values of gravisensitivity and to unravel molecular and cellular mechanisms of gravity sensing and gravity-related responses. By using the whole spectrum of experimental platforms, gravitational biologists gain deep insight into gravity-related biological processes and continuously increase our knowledge of how gravity affects life on Earth.

Item URL in elib:https://elib.dlr.de/125693/
Document Type:Book Section
Title:Methods for Gravitational Biology Research
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Hemmersbach, RuthGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Gravitational Biology, Cologne, Germanyhttps://orcid.org/0000-0001-5308-6715UNSPECIFIED
Häder, Donat-PeterEmeritus from Friedrich-Alexander-University of Erlangen, Institut of Biology, Erlangen, Germanyhttps://orcid.org/0000-0002-4295-5660UNSPECIFIED
Braun, MarkusGerman Aerospace Center (DLR), Space Administration, Bonn-Oberkassel, GermanyUNSPECIFIEDUNSPECIFIED
Date:21 July 2018
Journal or Publication Title:Gravitational Biology I. Gravity Sensing and Graviorientation in Microorganism and Plants
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:No
Page Range:pp. 13-26
EditorsEmailEditor's ORCID iDORCID Put Code
Braun, MarkusGerman Aerospace Center (DLR), Space AdministrationUNSPECIFIEDUNSPECIFIED
Böhmer, MaikUniversity of FrankfurtUNSPECIFIEDUNSPECIFIED
Häder, Donat-PeterUniversity of Erlangen (Emeritus)UNSPECIFIEDUNSPECIFIED
Hemmersbach, RuthGerman Aerospace Centre (DLR), Institute of Aerospace MedicineUNSPECIFIEDUNSPECIFIED
Palme, KlausUniversity of FreiburgUNSPECIFIEDUNSPECIFIED
Publisher:Springer Nature
Series Name:SpringerBriefs in Space Life Sciences
Keywords:Gravitational biology, Clinostat, Random Positioning Machine, Parabolic flight, ISS
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Biowissenschaftliche Exp.-vorbereitung (old), R - Vorhaben Biowissenschaftliche Nutzerunterstützung (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Gravitational Biology
Deposited By: Duwe, Helmut
Deposited On:10 Jan 2019 14:07
Last Modified:03 Aug 2023 08:48

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