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Normobaric hypoxic conditioning in men with metabolic syndrome

Klug, L. and Mahler, A. and Rakova, N. and Mai, K. and Schulz-Menger, J. and Rahn, G. and Busjahn, A. and Jordan, J. and Boschmann, M. and Luft, F.C. (2018) Normobaric hypoxic conditioning in men with metabolic syndrome. Physiological Reports. Wiley. DOI: https://doi.org/10.14814/phy2.13949 ISSN 2051-817X

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Official URL: https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.13949

Abstract

The evidence that physical exercise lowers metabolic and cardiovascular risk is undisputed. Normobaric hypoxia training has been introduced to facilitate the effects of exercise. We tested the hypothesis that hypoxia training augments exercise-related effects. We randomized 23 men with metabolic-syndrome to single-blinded exercise at normoxia (FiO2 21%) or hypoxia (FiO2 15%). Six weeks endurance training on a treadmill, 3 days per week, over 60 min at 60% VO2 max was required. The study included the following: (1) metabolic phenotyping by indirect calorimetry and adipose and muscle tissue microdialysis to gain insight into effects on resting, postprandial, and exercise metabolism, (2) cardiac imaging, and (3) biopsies. Primary endpoint was the change in cardiorespiratory fitness; secondary endpoints were as follows: changes in body weight, waist circumference, blood pressure, cardiac dimensions, and adipose and muscle tissue metabolism and gene expression. Our subjects reduced waist circumference and improved several cardiovascular risk markers including blood pressure. However, these effects were similar in both training groups. Cardiac dimensions were not influenced. We focused on glucose metabolism. After an oral glucose load, adipose tissue metabolism was significantly shifted to a more lipolytic state under hypoxia, whereas muscle metabolism was similar under both conditions. Postprandial energy expenditure was significantly increased under hypoxia, whereas activity energy expenditure was improved under normoxia. Gene expression was not consistently influenced by FiO2 . Adipose tissue triglyceride lipase, leptin, and hypoxia-inducible factor-alpha expression were increased by normoxia but not hypoxia.

Item URL in elib:https://elib.dlr.de/125534/
Document Type:Article
Title:Normobaric hypoxic conditioning in men with metabolic syndrome
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Klug, L.UNSPECIFIEDUNSPECIFIED
Mahler, A.UNSPECIFIEDUNSPECIFIED
Rakova, N.UNSPECIFIEDUNSPECIFIED
Mai, K.UNSPECIFIEDUNSPECIFIED
Schulz-Menger, J.UNSPECIFIEDUNSPECIFIED
Rahn, G.UNSPECIFIEDUNSPECIFIED
Busjahn, A.UNSPECIFIEDUNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Boschmann, M.Charite, BerlinUNSPECIFIED
Luft, F.C.Franz-Volhard Clinical Research Center, Medical University Charité, Campus Buch, Berlin, GermanyUNSPECIFIED
Date:20 December 2018
Journal or Publication Title:Physiological Reports
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:No
DOI :https://doi.org/10.14814/phy2.13949
Publisher:Wiley
ISSN:2051-817X
Status:Published
Keywords:Exercise training hypertension metabolic syndrome normobaric hypoxia
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:other
DLR - Research area:Raumfahrt
DLR - Program:R - no assignment
DLR - Research theme (Project):R - no assignment
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Gerlach, Darius
Deposited On:09 Jan 2019 11:01
Last Modified:05 Feb 2019 08:43

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