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Glucose Metabolism after Sleep Restriction, Total Sleep Deprivation, and Recovery

Elmenhorst, E.-M. and Hennecke, E. and Lange, D. and Fronczek, J. and Bauer, A. and Elmenhorst, D. and Aeschbach, D. (2018) Glucose Metabolism after Sleep Restriction, Total Sleep Deprivation, and Recovery. Experimental Biology Conference, 20.-25. April 2018, San Diego, USA.

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Abstract

Objective Sleep deficiency which is prevalent in shift work has been associated with an increased metabolic disease risk. Experimentally induced sleep restriction has been shown to impair glucose metabolism and has been linked to reduced slow wave sleep (SWS) as a possible causal factor. This study examined (i) whether total sleep deprivation exhibits similar effects on glucose tolerance and insulin sensitivity as sleep restriction, (ii) whether one recovery night after sleep restriction is sufficient to restore impaired glucose metabolism, and (iii) whether the combination of total sleep deprivation with prior sleep restriction shows cumulative effects. Methods Thirty-six healthy volunteers participated in a 12-day study. After one adaptation night and two baseline nights with 8 h of scheduled sleep each, sleep opportunities were restricted for 5 nights either to 5 h (21 participants, 9 females, mean ± SD, age 26 ± 4 yrs, BMI 23.1 ± 1.9) or maintained at 8 h (control, 15 participants, 5 females, age 28 ± 6 yrs, BMI 23.6 ± 2.9). Then, both groups underwent a single 8-h night of recovery sleep, a 38-h period of wakefulness, and a final recovery night. Oral glucose tolerance tests (OGTT) were conducted in the morning following lights on (>10 h fasting) after the second baseline night, after 5 nights of sleep restriction, after the first recovery night, and after 24 h of sleep deprivation. Blood was sampled immediately prior to the OGTT and then at 30-min intervals for 2 h. Polysomnograms were recorded. SWS per night and areas under the curve (AUC) for glucose, insulin, and HOMA were analyzed in each of the two groups with mixed ANOVAs with ‘sleep condition’ (4x) and ‘sex’ (2x) as factors (post-hoc Bonferroni-Holm adjustment). Results Glucose tolerance and insulin sensitivity decreased after sleep restriction (mean ± SEM, glucose Δ 32.5 ± 7.0 mg*h/dl, p<0.0001; insulin Δ 44.9 ± 9.2 mU*h/dl, p<0.0001; HOMA Δ 20.7 ± 3.9, p<0.0001) and remained low after recovery sleep (glucose Δ 17.3 ± 6.8 mg*h/dl, p=0.0139; insulin Δ 24.7 ± 9.2 mU*h/dl, p=0.0102; HOMA Δ 11.3 ± 3.8, p=0.0053) compared to baseline. After 24 h awake, these parameters were not different from baseline in both groups. The amount of SWS in the final sleep restriction night (Δ 0.6 ± 4.7 min, p=0.8949) and the recovery night (Δ 9.2 ± 4.7 min, p=0.0534) did not significantly differ from baseline. Conclusion Sleep restriction for 5 nights negatively impacts glucose metabolism. This impairment appears to occur independently of SWS, and to outlast a single night of recovery sleep. In contrast, prolonged wakefulness does neither acutely affect glucose metabolism nor exhibit cumulative effects with prior sleep restriction. Chronic sleep loss and acutely extended wake duration appear to activate different regulatory responses in glucose metabolism.

Item URL in elib:https://elib.dlr.de/125503/
Document Type:Conference or Workshop Item (Speech, Poster)
Title:Glucose Metabolism after Sleep Restriction, Total Sleep Deprivation, and Recovery
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Elmenhorst, E.-M.eva-maria.elmenhorst (at) dlr.deUNSPECIFIED
Hennecke, E.Eva.Hennecke (at) dlr.deUNSPECIFIED
Lange, D.UNSPECIFIEDUNSPECIFIED
Fronczek, J.UNSPECIFIEDUNSPECIFIED
Bauer, A.UNSPECIFIEDUNSPECIFIED
Elmenhorst, D.UNSPECIFIEDUNSPECIFIED
Aeschbach, D.Daniel.Aeschbach (at) dlr.deUNSPECIFIED
Date:April 2018
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Volume:32
Series Name:Faseb Journal
Status:Published
Keywords:sleep, shift work, metabolism
Event Title:Experimental Biology Conference
Event Location:San Diego, USA
Event Type:international Conference
Event Dates:20.-25. April 2018
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Aeronautics
HGF - Program Themes:air traffic management and operations
DLR - Research area:Aeronautics
DLR - Program:L AO - Air Traffic Management and Operation
DLR - Research theme (Project):L - Human factors and safety in Aeronautics
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Sleep and Human Factors Research
Deposited By: Meckes, Elke
Deposited On:09 Jan 2019 10:15
Last Modified:09 Jan 2019 10:15

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