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Cystathionine γ-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure

Szijártó, I.A and Markó, L. and Filipovic, M.R. and Miljkovic, J.L. and Tabeling, C. and Tsvetkov, D. and Wang, N. and Rabelo, L.A. and Witzenrath, M. and Diedrich, A. and Tank, J. and Akahoshi, N. and Kamata, S. and Ishii, I. and Gollasch, M. (2018) Cystathionine γ-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure. Hypertension, 71 (6), pp. 1210-1217. American Heart Association, Inc.. DOI: 10.1161/HYPERTENSIONAHA ISSN 0194-911X

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Official URL: https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.117.10562

Abstract

Hydrogen sulfide (H2S) and NO are important gasotransmitters, but how endogenous H2S affects the circulatory system has remained incompletely understood. Here, we show that CTH or CSE (cystathionine γ-lyase)-produced H2S scavenges vascular NO and controls its endogenous levels in peripheral arteries, which contribute to blood pressure regulation. Furthermore, eNOS (endothelial NO synthase) and phospho-eNOS protein levels were unaffected, but levels of nitroxyl were low in CTH-deficient arteries, demonstrating reduced direct chemical interaction between H2S and NO. Pretreatment of arterial rings from CTH-deficient mice with exogenous H2S donor rescued the endothelial vasorelaxant response and decreased tissue NO levels. Our discovery that CTH-produced H2S inhibits endogenous endothelial NO bioavailability and vascular tone is novel and fundamentally important for understanding how regulation of vascular tone is tailored for endogenous H2S to contribute to systemic blood pressure function.

Item URL in elib:https://elib.dlr.de/125385/
Document Type:Article
Title:Cystathionine γ-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Szijártó, I.AFrom the Experimental and Clinical Research Center (ECRC)-a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, GermanyUNSPECIFIED
Markó, L.From the Experimental and Clinical Research Center (ECRC)-a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, GermanyUNSPECIFIED
Filipovic, M.R.IBGC UMR 5095, Université de Bordeaux, FranceUNSPECIFIED
Miljkovic, J.L.IBGC UMR 5095, Université de Bordeaux, FranceUNSPECIFIED
Tabeling, C.Department of Infectious Diseases and Pulmonary Medicine, Charité Universitätsmedizin BerlinUNSPECIFIED
Tsvetkov, D.From the Experimental and Clinical Research Center (ECRC)-a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, BerlinUNSPECIFIED
Wang, N.From the Experimental and Clinical Research Center (ECRC)-a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, BerlinUNSPECIFIED
Rabelo, L.A.Max Delbrück Center for Molecular Medicine, Berlin, GermanyUNSPECIFIED
Witzenrath, M.CNRS, IBGC UMR 5095, Bordeaux, FranceUNSPECIFIED
Diedrich, A.Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Service, Vanderbilt University, Nashville, TNUNSPECIFIED
Tank, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Akahoshi, N.Department of Health Chemistry, Showa Pharmaceutical University, Tokyo, JapanUNSPECIFIED
Kamata, S.Hokkaido University, JapanUNSPECIFIED
Ishii, I.Department of Health Chemistry, Showa Pharmaceutical University, Tokyo, JapanUNSPECIFIED
Gollasch, M.From the Experimental and Clinical Research Center (ECRC)-a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, BerlinUNSPECIFIED
Date:June 2018
Journal or Publication Title:Hypertension
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:71
DOI :10.1161/HYPERTENSIONAHA
Page Range:pp. 1210-1217
Publisher:American Heart Association, Inc.
ISSN:0194-911X
Status:Published
Keywords:animals; hydrogen sulfide; hypertension; nitric oxide; nitric oxide synthase type III
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Becker, Christine
Deposited On:19 Dec 2018 09:56
Last Modified:06 Sep 2019 15:19

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