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Oparil, Suzanne and Acelajado, Maria Czarina and Bakris, George L. and Berlowitz, Dan R. and Cifkova, Renata and Dominiczak, Anna F. and Grassi, Guido and Jordan, Jens and Poulter, Neil R. and Rodgers, Anthony and Whelton, Paul K. (2018) Hypertension. Nature Reviews Disease Primers, 4, p. 18014. Springer. doi: 10.1038/nrdp.2018.14. ISSN 2056-676X.

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Official URL: https://www.nature.com/articles/nrdp201814


Systemic arterial hypertension is the most important modifiable risk factor for all-cause morbidity and mortality worldwide and is associated with an increased risk of cardiovascular disease (CVD). Fewer than half of those with hypertension are aware of their condition, and many others are aware but not treated or inadequately treated, although successful treatment of hypertension reduces the global burden of disease and mortality. The aetiology of hypertension involves the complex interplay of environmental and pathophysiological factors that affect multiple systems, as well as genetic predisposition. The evaluation of patients with hypertension includes accurate standardized blood pressure (BP) measurement, assessment of the patients’ predicted risk of atherosclerotic CVD and evidence of target-organ damage, and detection of secondary causes of hypertension and presence of comorbidities (such as CVD and kidney disease). Lifestyle changes, including dietary modifications and increased physical activity, are effective in lowering BP and preventing hypertension and its CVD sequelae. Pharmacological therapy is very effective in lowering BP and in preventing CVD outcomes in most patients; first-line antihypertensive medications include angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, dihydropyridine calcium-channel blockers and thiazide diuretics.

Item URL in elib:https://elib.dlr.de/125379/
Document Type:Article
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Oparil, SuzanneVascular Biology and Hypertension Program, School of Medicine, The University of AlabamaUNSPECIFIEDUNSPECIFIED
Acelajado, Maria CzarinaAthens-Limestone Hospital, Athens, AL, USAUNSPECIFIEDUNSPECIFIED
Bakris, George L.The University of Chicago Medicine, Chicago, IL, USAUNSPECIFIEDUNSPECIFIED
Berlowitz, Dan R.Center for Healthcare Organization and Implementation Research, Bedford Veteran Affairs Medical Center, Bedford, MA, USAUNSPECIFIEDUNSPECIFIED
Cifkova, RenataCenter for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Prague, Czech RepublicUNSPECIFIEDUNSPECIFIED
Dominiczak, Anna F.Institute of Cardiovascular and Medical Science, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UKUNSPECIFIEDUNSPECIFIED
Grassi, GuidoClinica Medica, University of Milano.Biocca and IRCCS Multimedica, Sesto Sangiovanni, Milan, ItalyUNSPECIFIEDUNSPECIFIED
Jordan, JensInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIEDUNSPECIFIED
Poulter, Neil R.Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, UKUNSPECIFIEDUNSPECIFIED
Rodgers, AnthonyThe George Institute for Global Health, Sydney, New South Wales, AustraliaUNSPECIFIEDUNSPECIFIED
Whelton, Paul K.Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USAUNSPECIFIEDUNSPECIFIED
Date:22 March 2018
Journal or Publication Title:Nature Reviews Disease Primers
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
Page Range:p. 18014
Keywords:Systemic arterial Hypertension;cardiovascular disease;
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Becker, Christine
Deposited On:09 Jan 2019 10:03
Last Modified:01 Oct 2020 18:18

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