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Airway and systemic inflammatory responses to ultrafine carbon black particles and ozone in older healthy subjects

Holz, Olaf and Heusser, Karsten and Müller, Meike and Windt, Horst and Schwarz, Katharina and Schindler, Christoph and Tank, Jens and Hohlfeld, Jens M. and Jordan, Jens (2018) Airway and systemic inflammatory responses to ultrafine carbon black particles and ozone in older healthy subjects. Journal of Toxicology and Environmental Health - Part A: Current Issues, 81 (13), pp. 576-588. Taylor & Francis. DOI: 10.1080/15287394.2018.1463331 ISSN 1528-7394

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Official URL: https://www.tandfonline.com/doi/full/10.1080/15287394.2018.1463331

Abstract

Increased adverse health effects in older subjects due to exposure to ambient air pollutants may be related to the inflammatory response induced by these contaminants. The aim of this study was to assess airway and systemic inflammatory responses in older healthy subjects to a controlled experimental exposure with spark-generated elemental carbon black ultrafine particles (cbUFPs) and ozone (O3). Twenty healthy subjects, age 52–75 years, were exposed on three occasions separated by at least 8 weeks. The exposures to filtered air (FA), to cbUFP (50 μg/m3), or to cbUFP in combination with 250 ppb ozone (cbUFP + O3) for 3 h with intermittent exercise were performed double blind, and in random order. Sputum and blood samples were collected 3.5 h after each exposure. Exposure to cbUFP + O3 significantly increased plasma club cell protein 16 (CC16), the number of sputum cells, the number and percent of sputum neutrophils, and sputum interleukin 6 and matrix metalloproteinase 9. Exposure to cbUFP alone exerted no marked effect, except for an elevation in sputum neutrophils in a subgroup of 13 subjects that displayed less than 65% sputum neutrophils after FA exposure. None of the inflammatory markers was correlated with age, and serum cardiovascular risk markers were not markedly affected by cbUFP or cbUFP + O3. Exposure to cbUFP+O3 induced a significant airway and systemic inflammatory response in older healthy volunteer subjects. The effects induced by cbUFP alone suggest that the inflammation was predominantly mediated by O3, although one cannot rule out that the interaction of cbUFP and O3 played a role.

Item URL in elib:https://elib.dlr.de/125376/
Document Type:Article
Title:Airway and systemic inflammatory responses to ultrafine carbon black particles and ozone in older healthy subjects
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Holz, OlafClinical Airway Research, Fraunhofer ITEM, Hannoverhttps://orcid.org/0000-0003-0665-7807
Heusser, KarstenInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Müller, MeikeClinical Airway Research, Fraunhofer ITEM, HannoverUNSPECIFIED
Windt, HorstClinical Airway Research, Fraunhofer ITEM, HannoverUNSPECIFIED
Schwarz, KatharinaClinical Airway Research, Fraunhofer ITEM, HannoverUNSPECIFIED
Schindler, ChristophHannover Medical School, HannoverUNSPECIFIED
Tank, JensGerman Aerospace Center, Institute of Aerospace Medicinehttps://orcid.org/0000-0002-5672-1187
Hohlfeld, Jens M.Clinical Airway Research, Fraunhofer ITEM, HannoverUNSPECIFIED
Jordan, JensInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Date:25 April 2018
Journal or Publication Title:Journal of Toxicology and Environmental Health - Part A: Current Issues
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:81
DOI :10.1080/15287394.2018.1463331
Page Range:pp. 576-588
Publisher:Taylor & Francis
ISSN:1528-7394
Status:Published
Keywords:Airway and systemic inflammatory; carbon black particles; air pollution
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Becker, Christine
Deposited On:19 Dec 2018 12:10
Last Modified:19 Dec 2018 12:10

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