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PlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics

Strewe, C. and Zeller, R. and Feuerecker, M. and Hoerl, M. and Matzel, S and Kumprej, I. and Crispin, A. and Johannes, B.W. and Debevec, T. and Mekjavic, I. and Eiken, O and Thiel, M and Schelling, G. and Choukèr, A. (2018) PlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics. Scientific Reports, 8 (1762), pp. 1-9. Nature Publishing Group. DOI: 10.1038/s41598-018-20045-5 ISSN 2045-2322

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Official URL: https://www.nature.com/articles/s41598-018-20045-5

Abstract

Adenosine plays a role in the energy supply of cells and provokes differential, hormone-like functions in circulating cells and various tissues. Its release is importantly regulated by oxygen tension. This renders adenosine and its kinetics interesting to investigate in humans subjected to low oxygen conditions. Especially for space exploration scenarios, hypoxic conditions – together with reduced gravity - represent two foreseen living conditions when planning manned long-duration space missions or planetary habitats. The PlanHab study investigated microgravity through inactivity in bed rest and normobaric hypoxia to examine their independent or combined effect on adenosine and its kinetics. Healthy male subjects (n = 14) completed three 21-day interventions: hypoxic bed rest (HBR); hypoxic ambulatory confinement (HAMB); normoxic bed rest (NBR). The interventions were separated by 4 months. Our hypothesis of a hypoxia-triggered increase in adenosine was confirmed in HAMB but unexpectedly also in NBR. However, the highest adenosine levels were noted following HBR. Furthermore, the percentage of hemolysis was elevated in HBR whereas endothelial integrity markers stayed low in all three interventions. In summary, these data suggest that neocytolysis accounts for these effects while we could reduce evidence for microcirculatory changes.

Item URL in elib:https://elib.dlr.de/124657/
Document Type:Article
Title:PlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Strewe, C.Department of Anaesthesiology , Klinikum Großhadern, University of Munich, Stress and Immunology Lab , Munich , GermanyUNSPECIFIED
Zeller, R.Department of Anaesthesiology , Klinikum Großhadern, University of Munich, Stress and Immunology Lab , Munich , GermanyUNSPECIFIED
Feuerecker, M.Department of Anaesthesiology , Klinikum Großhadern, University of Munich, Stress and Immunology Lab , Munich , GermanyUNSPECIFIED
Hoerl, M.Department of Anaesthesiology , Klinikum Großhadern, University of Munich, Stress and Immunology Lab , Munich , GermanyUNSPECIFIED
Matzel, SDepartment of Anaesthesiology, University Hospital, LMU Munich, Laboratory of Translational Research "Stress and Immunity", Munich, GermanyUNSPECIFIED
Kumprej, I.Department of Anaesthesiology , Klinikum Großhadern, University of Munich, Stress and Immunology Lab , Munich , GermanyUNSPECIFIED
Crispin, A.Department of Biometry and Epidemiology, Klinikum Großhadern , University of Munich , Munich , GermanyUNSPECIFIED
Johannes, B.W.Bernd.Johannes (at) dlr.deUNSPECIFIED
Debevec, T.Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, SloveniaUNSPECIFIED
Mekjavic, I.Jozef Stefan InstituteUNSPECIFIED
Eiken, ODepartment of Environmental Physiology, Swedish Aerospace Physiology Centre, Royal Institute of Technology, Stockholm, SwedenUNSPECIFIED
Thiel, MDepartment of Anaesthesiology and Surgical Intensive Care Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.UNSPECIFIED
Schelling, G.Department of Anaesthesiology , Klinikum Großhadern, University of Munich, Stress and Immunology Lab , Munich , GermanyUNSPECIFIED
Choukèr, A.Department of Anaesthesiology, Hospital of the University of Munich, Marchioninistrasse 15, München, 81377, Germany.UNSPECIFIED
Date:29 January 2018
Journal or Publication Title:Scientific Reports
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:8
DOI :10.1038/s41598-018-20045-5
Page Range:pp. 1-9
Publisher:Nature Publishing Group
ISSN:2045-2322
Status:Published
Keywords:normobaric hypoxia; bed rest; adenosine kinetics;
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:11 Dec 2018 12:16
Last Modified:11 Dec 2018 12:16

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