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Hypoxia aggravates inactivity-related muscle wasting

Debevec, Tadej and Ganse, Bergita and Mittag, Uwe and Eiken, Ola and Mekjavic, Igor B. and Rittweger, Jörn (2018) Hypoxia aggravates inactivity-related muscle wasting. Frontiers in Physiology, 9 (494), pp. 1-10. Frontiers Media S.A. DOI: 10.3389/fphys.2018.00494 ISSN 1664-042X

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Official URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962751/

Abstract

Poor musculoskeletal state is commonly observed in numerous clinical populations such as chronic obstructive pulmonary disease (COPD) and heart failure patients. It, however, remains unresolved whether systemic hypoxemia, typically associated with such clinical conditions, directly contributes to muscle deterioration. We aimed to experimentally elucidate the effects of systemic environmental hypoxia upon inactivity-related muscle wasting. For this purpose, fourteen healthy, male participants underwent three 21-day long interventions in a randomized, cross-over designed manner: (i) bed rest in normoxia (NBR; PiO2 = 133.1 ± 0.3 mmHg), (ii) bed rest in normobaric hypoxia (HBR; PiO2 = 90.0 ± 0.4 mmHg) and ambulatory confinement in normobaric hypoxia (HAmb; PiO2 = 90.0 ± 0.4 mmHg). Peripheral quantitative computed tomography and vastus lateralis muscle biopsies were performed before and after the interventions to obtain thigh and calf muscle cross-sectional areas and muscle fiber phenotype changes, respectively. A significant reduction of thigh muscle size following NBR (-6.9%, SE 0.8%; P < 0.001) was further aggravated following HBR (-9.7%, SE 1.2%; P = 0.027). Bed rest-induced muscle wasting in the calf was, by contrast, not exacerbated by hypoxic conditions (P = 0.47). Reductions in both thigh (-2.7%, SE 1.1%, P = 0.017) and calf (-3.3%, SE 0.7%, P < 0.001) muscle size were noted following HAmb. A significant and comparable increase in type 2× fiber percentage of the vastus lateralis muscle was noted following both bed rest interventions (NBR = +3.1%, SE 2.6%, HBR = +3.9%, SE 2.7%, P < 0.05). Collectively, these data indicate that hypoxia can exacerbate inactivity-related muscle wasting in healthy active participants and moreover suggest that the combination of both, hypoxemia and lack of activity, as seen in COPD patients, might be particularly harmful for muscle tissue.

Item URL in elib:https://elib.dlr.de/124655/
Document Type:Article
Title:Hypoxia aggravates inactivity-related muscle wasting
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Debevec, TadejDepartment of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, SloveniaUNSPECIFIED
Ganse, BergitaDepartment of Orthopaedic Trauma, RWTH Aachen University HospitalUNSPECIFIED
Mittag, UweUwe.Mittag (at) dlr.dehttps://orcid.org/0000-0002-8580-3085
Eiken, OlaDepartment of Environmental Physiology, Swedish Aerospace Physiology Centre, Royal Institute of Technology, Stockholm, SwedenUNSPECIFIED
Mekjavic, Igor B.Jozef Stefan InstituteUNSPECIFIED
Rittweger, JörnJoern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Date:15 May 2018
Journal or Publication Title:Frontiers in Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:9
DOI :10.3389/fphys.2018.00494
Page Range:pp. 1-10
Publisher:Frontiers Media S.A
ISSN:1664-042X
Status:Published
Keywords:muscle loss, bed rest, hypoxemia, vastus lateralis, fiber type
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:11 Dec 2018 12:11
Last Modified:11 Dec 2018 12:11

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